Hajime Tokuno, MD
Associate Professor of NeurologyCards
About
Research
Overview
1. The effect of botulinum toxins on chronic myofascial pain syndromes. We are actively enrolling in one study looking at the benefits of botulinum toxins for individuals with chronic neck or chronic back pain. The concept behind the use of botulinum toxins in subjects with chronic myofascial pain is based a belief that a significant part of the pain is due to unregulated muscular activity in the setting of mechanical injury.
2. The development of novel pain scores for tracking chronic pain conditions. We are developing several new pathways of pain scoring that may better predict outcomes in new treatment possibilities.
3. The clinical uses of infrared thermography in diagnosing and assessing severity of nerve or muscle injuries.
Medical Research Interests
Back Pain; Muscular Disorders, Atrophic; Musculoskeletal Diseases; Myofascial Pain Syndromes; Neck Pain; Neuromuscular Diseases; Peripheral Nervous System Diseases
Publications
2018
Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling
Geha P, Yang Y, Estacion M, Schulman B, Tokuno H, Apkarian A, Dib-Hajj S, Waxman S. Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling. 2018, 275-288. DOI: 10.7551/mitpress/10310.003.0031.Peer-Reviewed Original Research
2006
Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord
Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord. Journal Of Neuroscience 2006, 26: 1803-1812. PMID: 16467529, PMCID: PMC2605396, DOI: 10.1523/jneurosci.3611-05.2006.Peer-Reviewed Original ResearchConceptsDemyelinated spinal cordSpecific membrane domainsSpinal cordVoltage-gated ion channelsGreen fluorescent proteinTransplanted Olfactory Ensheathing CellsMature NodalMembrane domainsSpinal cord demyelinationOlfactory Ensheathing CellsVivo electrophysiological recordingsFluorescent proteinJuxtaparanodal domainsMolecular reconstructionIon channelsMature nodesRemyelinated axonsExtensive remyelinationUninjured axonsKv channelsDemyelinated axonsDonor ratsCentral axonsGlial cellsJuxtaparanodal region
2004
Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
Tokuno HA, Bradberry CW, Everill B, Agulian SK, Wilkes S, Baldwin RM, Tamagnan GD, Kocsis JD. Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves. Brain Research 2004, 996: 159-167. PMID: 14697493, DOI: 10.1016/j.brainres.2003.10.024.Peer-Reviewed Original ResearchConceptsAgonist substitution therapyLocal anesthetic propertiesCompound action potentialSubstitution therapyDorsal rootsAnesthetic propertiesCocaine rewardDorsal root ganglion neuronsSucrose gap chamberUse-dependent blockadeRat peripheral nerveLocal anesthetic effectRat sciatic nerveDopamine uptake inhibitorPotential pharmacological toolsPatch-clamp studiesCAP amplitudeGanglion neuronsSciatic nervePeripheral nervesClinical studiesTreatment candidatesClamp studiesStimulus trainsImpulse blockade
News & Links
Media
- The patient in this false color image has a foot drop on the right side due to a peroneal nerve injury (confirmed by EMG). The left leg (seen here on the right of the photo) shows a bright signal due to the normal heat output from an intact tibialis anterior muscle.