2023
Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomesSex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomesImpact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo‐Cordovez C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Impact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction. Journal Of The American Heart Association 2023, 12: e030031. PMID: 37589125, PMCID: PMC10547344, DOI: 10.1161/jaha.123.030031.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac-specific qualityGeneric health statusMyocardial infarctionBaseline healthMarital stressHealth outcomesHealth statusWorse patient-reported outcomesMental healthYoung adultsObservational cohort studyPatient-reported outcomesSocioeconomic factorsWorse mental healthReadmission 1Cause readmissionCohort studyYounger patientsRoutine screeningDepressive symptomsGreater oddsAnginaMale participantsOutcomes
2024
Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction.
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction. PLOS ONE 2024, 19: e0287949. PMID: 38277368, PMCID: PMC10817183, DOI: 10.1371/journal.pone.0287949.Peer-Reviewed Original ResearchConceptsMarital/partner statusPsychosocial factorsAcute myocardial infarctionYoung adultsHospital dischargeYear of hospital dischargeYoung acute myocardial infarctionAssociated with 1.3-foldCohort of young adultsLong-term readmissionCox proportional hazards modelsStatus interactionSimilar-aged menMyocardial infarctionProportional hazards modelUnpartnered statusPatient interviewsPhysician panelCardiovascular healthHospital readmissionSocioeconomic factorsAMI survivorsSequential adjustmentCardiac readmissionMultiple imputation
2017
Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain
Lindau S, Abramsohn E, Bueno H, D’Onofrio G, Lichtman J, Lorenze N, Sanghani R, Spatz E, Spertus J, Strait K, Wroblewski K, Zhou S, Krumholz H. Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain. Obstetrical & Gynecological Survey 2017, 72: 334-335. DOI: 10.1097/01.ogx.0000516136.75506.a3.Peer-Reviewed Original Research
2015
SEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS)
Dreyer R, Wang Y, Strait K, Lorenze N, D’Onofrio G, Bueno H, Lichtman J, Spertus J, Krumholz H. SEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS). Journal Of The American College Of Cardiology 2015, 65: a6. DOI: 10.1016/s0735-1097(15)60006-7.Peer-Reviewed Original Research
2013
SEX-SPECIFIC TRENDS IN HOSPITALIZATIONS AMONG YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN UNITED STATES, 2001-2010
Gupta A, Wang Y, Spertus J, Geda M, Lorenze N, D'Onofrio G, Lichtman J, Krumholz H. SEX-SPECIFIC TRENDS IN HOSPITALIZATIONS AMONG YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN UNITED STATES, 2001-2010. Journal Of The American College Of Cardiology 2013, 61: e1483. DOI: 10.1016/s0735-1097(13)61483-7.Peer-Reviewed Original Research
2010
Variation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomen
2006
Elderly women experience lower rates of 5-year mortality following stroke in the United States
Lichtman J, Krumholz H, Wang Y, Brass L. Elderly women experience lower rates of 5-year mortality following stroke in the United States. Gender Medicine 2006, 3: s58. DOI: 10.1016/s1550-8579(06)80129-4.Peer-Reviewed Original ResearchGender differences in mortality among nonagenarians undergoing coronary artery bypass procedures in the United States: 1993–1999
Lichtman J, Wang Y, Radford M, Brass L, Krumholz H. Gender differences in mortality among nonagenarians undergoing coronary artery bypass procedures in the United States: 1993–1999. Gender Medicine 2006, 3: s25. DOI: 10.1016/s1550-8579(06)80035-5.Peer-Reviewed Original Research
2004
1040-76 30-day mortality trends following acute myocardial infarction in the elderly
Lichtman J, Wang Y, Normand S, Shen R, Brass L, Krumholz H. 1040-76 30-day mortality trends following acute myocardial infarction in the elderly. Journal Of The American College Of Cardiology 2004, 43: a403. DOI: 10.1016/s0735-1097(04)91702-0.Peer-Reviewed Original Research885-1 National mortality trends in elderly patients hospitalized with heart failure between 1992 and 1999
Kosiborod M, Lichtman J, Wang Y, Brass L, Krumholz H. 885-1 National mortality trends in elderly patients hospitalized with heart failure between 1992 and 1999. Journal Of The American College Of Cardiology 2004, 43: a239-a240. DOI: 10.1016/s0735-1097(04)91020-0.Peer-Reviewed Original Research885-2 The burden of vascular disease in long-term follow-up of elderly myocardial infarction survivors
Portnay E, Krumholz H, Wang Y, Hebert P, Brass L, Lichtman J. 885-2 The burden of vascular disease in long-term follow-up of elderly myocardial infarction survivors. Journal Of The American College Of Cardiology 2004, 43: a240. DOI: 10.1016/s0735-1097(04)91021-2.Peer-Reviewed Original Research1096-70 Severe concomitant conditions, physician volumes and outcomes in acute myocardial infarction
Lichtman J, Lin Z, Fathi A, Radford M, Wu J, Loesser C, Krumholz H. 1096-70 Severe concomitant conditions, physician volumes and outcomes in acute myocardial infarction. Journal Of The American College Of Cardiology 2004, 43: a408. DOI: 10.1016/s0735-1097(04)91723-8.Peer-Reviewed Original Research
2002
Risk and predictors of stroke after myocardial infarction among the elderly: results from the cooperative cardiovascular project
Lichtman J, Krumholz H, Wang Y, Radford M, Brass L. Risk and predictors of stroke after myocardial infarction among the elderly: results from the cooperative cardiovascular project. ACC Current Journal Review 2002, 11: 18. DOI: 10.1016/s1062-1458(02)00762-6.Peer-Reviewed Original ResearchElevated serum creatinine and increased mortality in women and elderly heart failure patients
Smith G, Radford M, Rathore S, Lichtman J, Watnick S, Krumholz H. Elevated serum creatinine and increased mortality in women and elderly heart failure patients. Journal Of The American College Of Cardiology 2002, 39: 441. DOI: 10.1016/s0735-1097(02)81983-0.Peer-Reviewed Original ResearchWorsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith G, Vaccarino V, Kosiborod M, Lichtman J, Cheng S, Krumholz H. Worsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of The American College Of Cardiology 2002, 39: 461. DOI: 10.1016/s0735-1097(02)82070-8.Peer-Reviewed Original Research
2001
Can Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study
Lichtman J, Roumanis S, Radford M, Riedinger M, Weingarten S, Krumholz H. Can Practice Guidelines Be Transported Effectively to Different Settings? Results from a Multicenter Interventional Study. The Joint Commission Journal On Quality And Patient Safety 2001, 27: 42-53. PMID: 11147239, DOI: 10.1016/s1070-3241(01)27005-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainConnecticutFollow-Up StudiesHealth Care SurveysHospitalizationHumansInterviews as TopicMaleMiddle AgedNebraskaNorth CarolinaOutcome Assessment, Health CarePatient DischargePatient SatisfactionPennsylvaniaPractice Guidelines as TopicProspective StudiesSouth CarolinaSurveys and QuestionnairesConceptsChest painClinical guidelinesIntervention periodGuideline adherenceGuideline implementationPatient outcomesLow-risk chest pain patientsLow-risk chest painStandardized protocolMulticenter interventional studyLow-risk patientsChest pain patientsInterventional trialsPain patientsSuccessful translationClinical outcomesGuideline periodInterventional studyPatient satisfactionPatient's physicianPractice guidelinesHospital settingBaseline valuesClinical practicePain
2000
Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction
Brass L, Lichtman J, Wang Y, Gurwitz J, Radford M, Krumholz H. Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction. Stroke 2000, 31: 1802-1811. PMID: 10926938, DOI: 10.1161/01.str.31.8.1802.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionThrombolytic therapyIntracranial hemorrhageMyocardial infarctionElderly patientsIntracranial Hemorrhage AssociatedRetrospective cohort studyRisk stratification scaleMain outcome measuresAcute care hospitalsTissue plasminogen activatorExcessive anticoagulationPrior strokeCohort studyOlder patientsBlood pressureHemorrhage AssociatedIndependent predictorsMedical chartsSerious complicationsMedian weightAlternate therapyBlack racePrincipal diagnosisMedicare patients