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Everyone (Public)

YSPH Biostatistics Seminar- "Causal Graphical Models for Discovering Gene Regulations"

BIS 526 students are required to attend in person. Others are allowed to attend in person, but may also attend via zoom.

Speaker- Yang Ni, Ph.D.

Title - Causal Graphical Models for Discovering Gene Regulations


I will present several causal graphical models for discovering gene regulations from observational genomic data in an exploratory fashion. Our methods are specifically tailored to common features of genomic data including high level of noise, high skewness, zero-inflation, sample heterogeneity, feedback loops, and presence of unmeasured confounders. Our theories show that causal structure is identifiable under all the presented causal graphical models with purely observational data. I will provide intuition as to why causality is identifiable under different scenarios and demonstrate the practical utility using multiple real datasets with known causal structure.


  • Texas A&M University

    Yang Ni
    Assistant Professor


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