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DTSTART:20241103T020000
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DESCRIPTION:Streptococcus pneumoniae is the leading cause of pneumonia mor
 tality worldwide and is responsible for >300\,000 deaths in children unde
 r 5 years of age each year. Childhood vaccination programs resulted in a 
 decrease in disease caused by vaccine serotypes\, but serotype replacemen
 t resulted in a simultaneous increase in carriage and disease caused by n
 on-vaccine serotypes. A key driver of serotype replacement is capsule-swi
 tching\, which is the expansion of non-vaccine serotypes within vaccine-t
 ype genetic lineages. Genetic analyses suggest that specific serotype pai
 rs switch preferentially\, but the mechanisms behind this remain poorly u
 nderstood. Our work focuses on characterizing the fitness of capsule-swit
 ch variants and providing an improved understanding of genetic and metabo
 lic constraints on this process. We aim to be ablet to predict capsule-sw
 itch variants that are most likely to emerge in the future and use this t
 o guide serotype inclusion for next generation vaccines\n\nAdmission:\nFr
 ee\n\nDetails URL:\nhttps://medicine.yale.edu/event/ysph-emd-seminar-27/\
 n
DTEND;TZID=America/New_York:20230301T130000
DTSTAMP:20261102T094821Z
DTSTART;TZID=America/New_York:20230301T120000
GEO:41.303509;-72.931937
LOCATION:115\, 60 College Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH EMD Seminar: “How serotype replacement threatens the success 
 of pneumococcal vaccination programs worldwide”
UID:7a326972-78d8-4efb-a539-2b47478191cb
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