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DTSTART:20241103T020000
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DTSTART:20250309T020000
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DESCRIPTION:NOTE: BIS 526 students are required to attend in person (47 Co
 llege St.\, Room 106A). All others are requested to attend via Zoom. Spea
 ker Daniel Almirall\, Ph.D. Title- "Clustered sequential\, multiple\, ran
 domized trials for developing cluster-level adaptive interventions: Estim
 ation and sample size considerations" Abstract Individual-level adaptive 
 interventions\, also known as dynamic treatment regimens\, are used to se
 quence treatment decisions based on a person’s static and changing health
  information. We introduce cluster-level adaptive interventions (CAIs): p
 re-specified decision rules guiding the provision of intervention at the 
 cluster level\, but with the goal of improving outcomes for individuals w
 ithin a cluster. We present clustered sequential\, multiple-assignment\, 
 randomized trial designs (SMARTs)\, which are used to develop optimized C
 AIs. In a clustered SMART\, clusters are randomized multiple times\, at c
 ritical intervention decision points\; and primary outcomes are at the in
 dividual-level. We develop a weighted least squares regression approach t
 o compare the CAIs embedded in a cluster-randomized SMART. We also develo
 p a sample size calculator for designing cluster-randomized SMARTs when t
 he goal is to compare two CAIs that begin with different first-stage inte
 rventions. The methods are illustrated using the Adaptive School-based Im
 plementation of CBT Trial (ASIC)\, which is currently underway. The goal 
 of ASIC is to develop a CAI to improve the adoption/implementation of cog
 nitive behavioral therapy (CBT) by school professionals across Michigan.\
 n\nAdmission:\nFree\n\nDetails URL:\nhttps://medicine.yale.edu/event/ysph
 -biostatistics-seminar-tbn-38/\n
DTEND;TZID=America/New_York:20220308T130000
DTSTAMP:20261022T060237Z
DTSTART;TZID=America/New_York:20220308T120000
GEO:41.302961;-72.931638
LOCATION:106A\, 47 College Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH Biostatistics Seminar - "Clustered Sequential\, Multiple\, Ra
 ndomized Trials for Developing Cluster-level Adaptive Interventions: Esti
 mation and Sample Size Considerations"
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