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DTSTART:20241103T020000
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DESCRIPTION:Attendance via Zoom. Speaker- Lu Mao\, Ph.D. Title- "On restri
 cted mean time in favor of treatment" Abstract The restricted mean time i
 n favor (RMT-IF) of treatment is a nonparametric effect size for complex 
 life history data. It is defined as the net average time the treated spen
 d in a more favorable state than the untreated over a prespecified time w
 indow. It generalizes the familiar restricted mean survival time (RMST) f
 rom the two-state life–death model to account for intermediate stages in 
 disease progression. The overall estimand can be additively decomposed in
 to stage-wise effects\, with the standard RMST as a component. Alternate 
 expressions of the overall and stage-wise estimands as integrals of the m
 arginal survival functions for a sequence of landmark transitioning event
 s allow them to be easily estimated by plug-in Kaplan–Meier estimators. T
 he dynamic profile of the estimated treatment effects as a function of fo
 llow-up time can be visualized using a multilayer\, cone-shaped “bouquet 
 plot.” Simulation studies under realistic settings show that the RMT-IF m
 eaningfully and accurately quantifies the treatment effect and outperform
 s traditional tests on time to the first event in statistical efficiency 
 thanks to its fuller utilization of patient data. The new methods are ill
 ustrated on a colon cancer trial with relapse and death as outcomes and a
  cardiovascular trial with recurrent hospitalizations and death as outcom
 es. The R-package rmt implements the proposed methodology and is publicly
  available from the Comprehensive R Archive Network (CRAN). (https://doi.
 org/10.1111/biom.13570 )\n\nSpeaker:\nLu Mao\n\nAdmission:\nFree\n\nDetai
 ls URL:\nhttps://medicine.yale.edu/event/ysph-biostatistics-seminar-125/\
 n
DTEND;TZID=America/New_York:20220125T130000
DTSTAMP:20260413T160612Z
DTSTART;TZID=America/New_York:20220125T120000
GEO:41.302961;-72.931638
LOCATION:106A\, 47 College Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH Biostatistics Seminar: "On restricted mean time in favor of t
 reatment"
UID:8605af1c-6cea-47ce-93ef-4243457617a4
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