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TZID:America/New_York
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DTSTART:20241103T020000
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TZNAME:EST
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DTSTART:20250309T020000
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DESCRIPTION:Registration required Differential expression analysis (e.g.\,
  DESeq2\, limma) is powerful for identifying molecules whose expression c
 hanges across conditions. However\, it often yields long gene lists that 
 can be difficult to interpret biologically. Pathway analysis methods such
  as over-representation analysis (ORA) and Gene Set Enrichment Analysis (
 GSEA) summarize results by testing overlap between differentially express
 ed genes and predefined signatures\, but typically do not explicitly inco
 rporate known molecular interactions among the genes. Protein–protein int
 eraction (PPI) network analysis helps translate a list into biology by pl
 acing differentially expressed genes into the context of known and predic
 ted molecular interactions. This context can reveal coordinated pathways 
 and protein complexes\, highlight modules of functionally related genes\,
  and help prioritize candidate “key” (hub) proteins that connect multiple
  altered processes—supporting hypothesis generation and targeted follow-u
 p.In this hands-on workshop\, participants will use Cytoscape and the STR
 ING database (via stringApp) to build and analyze a PPI network from a DE
 Seq2-derived list of differentially expressed genes from Alzheimer’s dise
 ase fusiform gyrus data.In this session\, attendees will learn how to: Im
 port differential expression results and retrieve STRING interaction netw
 orks in Cytoscape Apply confidence thresholds to reduce noise Overlay exp
 ression statistics (e.g.\, log⁡2FC\, adjusted p-value) onto the network I
 dentify hub proteins in the network Analyze the network to identify and a
 nnotate functional clusters/modules Prerequisites: Bring a laptop with th
 e latest version of Cytoscape installed No command-line or scripting expe
 rience required\n\nSpeaker:\nRolando Garcia-Milian\n\nAdmission:\nFree\n\
 nDetails URL:\nhttps://medicine.yale.edu/event/from-differential-expressi
 on-to-mechanism-protein-protein-interaction-network-analysis-with-string/
 \n
DTEND;TZID=America/New_York:20260916T120000
DTSTAMP:20260902T211548Z
DTSTART;TZID=America/New_York:20260916T100000
GEO:41.303230;-72.933870
LOCATION:Sterling Hall of Medicine\, L-Wing\, 111\, 333 Cedar Street\, New
  Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:From Differential Expression to Mechanism: Protein–Protein Interac
 tion Network Analysis with STRING
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