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DTSTART:20241103T020000
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DESCRIPTION:SPEAKER : Yong Chen\, PhD\, Professor of Biostatistics\, Depar
 tment of Biostatistics\, Epidemiology\, and Informatics\, University of P
 ennsylvania Perelman School of Medicine. TITLE : “MOSAiC: A Unified Frame
 work for Lossless\, One-shot\, Federated Learning Algorithms” ABSTRACT: M
 ulti-site studies are now central to biomedical research\, but inference 
 across sites remains challenging due to regulatory limits on sharing indi
 vidual-level data\, heterogeneous data distributions\, sparse events in s
 mall centers\, and the logistical burden of multi-round communication. In
  this talk\, I introduce MOSAiC (Multi-site One-Shot Aggregation of Compr
 essed Risk Functions)\, a unified framework for modern distributed resear
 ch networks. Notably\, MOSAiC reframes distributed learning as a mathemat
 ical problem of compressing and aggregating risk functions\, leveraging r
 ecent advances in tensor networks—state-of-the-art tools for high-dimensi
 onal function approximation in scientific computing. Our MOSAiC enjoys fo
 ur desirable properties that have never been achieved by any of the exist
 ing federated algorithms (except linear regressions): one-shot communicat
 ion\, lossless recovery of pooled-data estimates\, inclusiveness of all s
 ites irrespective of size or event rarity\, and analytic submodel exploit
 ability without re-querying partners. I will illustrate MOSAiC’s validity
  and efficiency through applications in drug relabeling\, drug repurposin
 g\, and post-market safety surveillance. The talk will highlight our fort
 hcoming discussion paper in the Journal of the American Statistical Assoc
 iation (Applications and Case Studies) (https://www.tandfonline.com/doi/f
 ull/10.1080/01621459.2026.2698025 )\, along with several ongoing extensio
 ns and applications. YSPH values inclusion and access for all participant
 s. If you have questions about accessibility or would like to request an 
 accommodation\, please contact Charmila Fernandes at Charmila.fernandes@y
 ale.edu . We will try to provide accommodations requested by October 21\,
  2026.\n\nSpeaker:\nYong Chen\, PhD\n\nAdmission:\nFree\n\nFood:\nRefresh
 ments at 3:45 PM\n\nDetails URL:\nhttps://medicine.yale.edu/event/ysph-bi
 ostatistics-seminar-10-26-26-copy/\n
DTEND;TZID=America/New_York:20261026T170000
DTSTAMP:20261021T115228Z
DTSTART;TZID=America/New_York:20261026T160000
GEO:41.303666;-72.932218
LOCATION:Yale School of Public Health (LEPH)\, 115\, 60 College Street\, N
 ew Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH Biostatistics Seminar: "MOSAiC: A Unified Framework for Lossl
 ess\, One-shot\, Federated Learning Algorithms"
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