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DTSTART:20241103T020000
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DESCRIPTION:SPEAKER : Annette Molinaro\, PhD\, Zelda d'Angleterre Glazer’s
  Endowed Chair in Brain Tumor Research\; Professor\, Neurological Surgery
  & Epidemiology and Biostatistics\; Director\, Division of Biomedical Sta
 tistics and Informatics\; University of California\, San Francisco TITLE 
 : “The Role of Statistics in Changing Glioma Patient Care” ABSTRACT: Diff
 use gliomas are diagnosed in approximately 100\,000 people worldwide each
  year\, and glioblastoma remains the most lethal primary brain tumor. Ove
 r the past decade\, molecular markers have changed how these tumors are c
 lassified\, treated\, and studied. Each change has depended on large\, we
 ll-annotated cohorts and on statistical methods matched to the clinical q
 uestion. This talk describes how statistical and machine learning methods
  developed and applied at UCSF have informed glioma care. The first examp
 le is how molecular classification defined by IDH\, 1p/19q\, and TERT pro
 moter status (Eckel-Passow\, Lachance\, Molinaro\, et al.\, NEJM 2015) in
 formed the 2016 WHO classification and continue to guide molecular charac
 terization of newly diagnosed glioblastoma. Subsequent examples include r
 ecursive partitioning to identify which patients benefit from more extens
 ive surgical resection in IDH-wildtype and IDH-mutant glioma. Recursive p
 artitioning and other machine learning methods are also applied to periph
 eral blood immune profiles derived from DNA methylation\, to develop prog
 nostic and predictive biomarkers\, including for response to immunotherap
 y. The final example is deep learning applied to digital pathology for ri
 sk stratification. Throughout\, the emphasis is on methods that return an
 swers clinicians can act on: thresholds\, risk groups\, and decision rule
 s. YSPH values inclusion and access for all participants. If you have que
 stions about accessibility or would like to request an accommodation\, pl
 ease contact Charmila Fernandes at Charmila.fernandes@yale.edu . We will 
 try to provide accommodations requested by November 11\, 2026.\n\nSpeaker
 :\nAnnette Molinaro\, PhD\n\nAdmission:\nFree\n\nFood:\nRefreshments at 3
 :45 PM\n\nDetails URL:\nhttps://medicine.yale.edu/event/ysph-biostatistic
 s-seminar-tba-11-16-26/\n
DTEND;TZID=America/New_York:20261116T170000
DTSTAMP:20261021T232044Z
DTSTART;TZID=America/New_York:20261116T160000
GEO:41.303666;-72.932218
LOCATION:Yale School of Public Health (LEPH)\, 115\, 60 College Street\, N
 ew Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH Biostatistics Seminar: “The Role of Statistics in Changing Gl
 ioma Patient Care”
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