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DTSTART:20241103T020000
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DESCRIPTION:Note: BIS 526 students are required to attend in person. Other
 s are invited to attend in person but may also attend via zoom. Speaker- 
 Danyu Liu\, Ph.D. Title- "Evaluating the Effectiveness of COVID-19 Vaccin
 es Over Time” Abstract Approximately 800 million COVID-19 cases and 7 mil
 lion COVID-19 deaths have been reported to the World Health Organization 
 thus far. Vaccination is a major tool to combat the COVID-19 pandemic\, b
 ut its effectiveness wanes over time and tends to be lower against new SA
 RS-CoV-2 variants. The knowledge about the waning effects of vaccination 
 can guide boosting strategies. In a series of papers published in The New
  England Journal of Medicine and JAMA \, we reported several large cohort
  studies using COVID-19 case surveillance and vaccination data from the s
 tates of North Carolina and Nebraska. We developed a novel statistical fr
 amework to evaluate the time-varying effects of four generations of COVID
 -19 vaccines produced in the United States on infections with different S
 ARS-CoV-2 variants and on severe outcomes (hospitalization and death). Ou
 r findings have been cited by the World Health Organization and the U.S. 
 Centers for Disease Control and Prevention and Food and Drug Administrati
 on and reported by The New York Times \, The Washington Post \, ABC News 
 \, and NBC News . References Lin DY\, Gu Y\, Wheeler B\, Young H\, Hollow
 ay S\, Sunny SK\, Moore Z\, Zeng D (2022). Effectiveness of Covid-19 vacc
 ines over a 9-month period in North Carolina. New England Journal of Medi
 cine 386: 933-941. https://www.nejm.org/doi/full/10.1056/NEJMoa2117128 Li
 n DY\, Gu Y\, Xu Y\, Wheeler B\, Young H\, Sunny SK\, Moore Z\, Zeng D (2
 022). Association of primary and booster vaccination and prior infection 
 with SARS-CoV-2 infection and severe COVID-19 outcomes. JAMA 328: 1415-14
 26. https://jamanetwork.com/journals/jama/fullarticle/2796893 Lin DY\, Gu
  Y\, Xu Y\, Zeng D\, Wheeler B\, Young H\, Sunny SK\, Moore Z (2022). Eff
 ects of vaccination and previous infection on omicron infections in child
 ren. New England Journal of Medicine 387: 1141-1143. https://www.nejm.org
 /doi/full/10.1056/NEJMc2209371 Lin DY\, Xu Y\, Gu Y\, Zeng D\, Wheeler B\
 , Young H\, Sunny SK\, Moore Z (2023). Effectiveness of bivalent boosters
  against severe omicron infection. New England Journal of Medicine 388: 7
 64-766. https://www.nejm.org/doi/full/10.1056/NEJMc2215471 Lin DY\, Du Y\
 , Xu Y\, Paritala S\, Donahue M\, Maloney P (2024). Durability of XBB.1.5
  vaccines against omicron subvariants. New England Journal of Medicine 39
 0:2124-2127. https://www.nejm.org/doi/full/10.1056/NEJMc2402779 Du Y\, Pa
 ritala S\, Xu Y\, Maloney P\, Lin DY. Durability of 2024-2025 COVID-19 va
 ccines against JN. 1 subvariants (with commentary by Robert M Califf). JA
 MA Internal Medicine 185:1501-1504. https://jamanetwork.com/journals/jama
 internalmedicine/fullarticle/2840565\n\nAdmission:\nFree\n\nDetails URL:\
 nhttps://medicine.yale.edu/event/ysph-biostatistics-seminar-14/\n
DTEND;TZID=America/New_York:20260414T130000
DTSTAMP:20261024T131756Z
DTSTART;TZID=America/New_York:20260414T120000
GEO:41.302961;-72.931638
LOCATION:106 A&B\, 47 College Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH Biostatistics Seminar- “Evaluating the Effectiveness of COVID
 -19 Vaccines Over Time”
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