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DTSTART:20241103T020000
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DESCRIPTION:The rise of antibiotic resistance warrants exploration of nove
 l approaches to target and kill bacterial pathogens. Phage therapy offers
  a possible alternative\, but a downside is the ability for target bacter
 ia to evolve phage resistance. Our goal is to develop phages that steer e
 volutionary ‘trade-offs’: these viruses bind to virulence factors of targ
 et bacteria to select for phage-resistance that compromises the function 
 of structures responsible for bacterial pathogenicity. This approach is d
 emonstrated in personalized medicine\, where phage ‘steering’ in patients
  provides clinical benefits\, such as changing the infecting bacteria to 
 become re-sensitized to chemical antibiotics and decreasing their ability
  to cause tissue inflammation. YSPH values inclusion and access for all p
 articipants If you have questions about accessibility or would like to re
 quest an accommodation\, please contact Christina Ciarleglio at christina
 .ciarleglio@yale.edu.\n\nSpeaker:\nPaul Turner\n\nAdmission:\nFree\n\nDet
 ails URL:\nhttps://medicine.yale.edu/event/emd-seminar-series-25-10/\n
DTEND;TZID=America/New_York:20241030T125000
DTSTAMP:20261018T122651Z
DTSTART;TZID=America/New_York:20241030T120000
GEO:41.303666;-72.932218
LOCATION:Yale School of Public Health (LEPH)\, Winslow Auditorium\, 60 Col
 lege Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:CANCELED - EMD Seminar Series: Paul Turner - Leveraging evolutiona
 ry trade-offs in the development of phage therapy
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