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DTSTART:20241103T020000
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DESCRIPTION:Three highly pathogenic coronaviruses – SARS-CoV-1 in 2002\, M
 ERS-CoV in 2012\, and SARS-CoV-2 in 2019 – from the genus Betacoronavirus
  emerged into immune naïve humans which underlines the global public heal
 th threat posed by Betacoronaviruses. A major focus of our work relates t
 o the design of next generation “universal” coronavirus vaccines approach
 es. We developed chimeric spike mRNAs that protect in vivo against SARS-C
 oV-2 variants and bat zoonotic SARS1-related viruses. We have defined vul
 nerable regions in SARS-CoV-2 and bat SARS1-related spikes that are targe
 ts of human broadly neutralizing antibodies. The identification of highly
  conserved epitopes in the spike RBD led us to recently develop multivale
 nt nanoparticle vaccines that express receptor binding domains (RBDs) fro
 m both SARS-related and MERS-related viruses. We recently demonstrated th
 at a single vaccine protects in mice against both lethal SARS-CoV-1 and h
 ighly pathogenic MERS-CoV challenge and neutralized SARS-CoV-2 variants i
 ncluding XBB.1.5. A trivalent RBD nanoparticle vaccine elicits broadly cr
 oss-reactive antibodies. Thus\, a single vaccine protects against Group 2
 B/2C Betacoronavirus challenge in mice. YSPH values inclusion and access 
 for all participants. If you have questions about accessibility or would 
 like to request an accommodation\, please contact Maria Reilly at maria.r
 eilly@yale.edu . We will try to provide accommodations requested by 9/18/
 2023.\n\nSpeaker:\nDavid Martinez\n\nAdmission:\nFree\n\nFood:\n\n\nDetai
 ls URL:\nhttps://medicine.yale.edu/event/emd-seminar-series-5/\n
DTEND;TZID=America/New_York:20230920T130000
DTSTAMP:20260602T142631Z
DTSTART;TZID=America/New_York:20230920T120000
GEO:41.303666;-72.932218
LOCATION:Yale School of Public Health (LEPH)\, Winslow Auditorium\, 60 Col
 lege Street\, New Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:EMD Seminar Series: David Martinez\, "Immunologic approaches to em
 erging RNA viruses"
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