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DTSTART:20241103T020000
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DESCRIPTION:In sub-Saharan Africa\, nearly 1 in 5 people are diagnosed wit
 h malaria every year\, most of whom are pregnant women and children. Chem
 oprevention with efficacious antimalarials can be a valuable tool in both
  control and elimination settings through treating existing and preventin
 g new infections. In moderate-to-high transmission settings\, sulfadoxine
 - pyrimethamine (SP) is the most common antimalarial used in chemoprevent
 ion regimens for pregnant women and children. However\, in the past two d
 ecades\, SP has been losing its efficacy due to drug resistance. Numerous
  trials in pregnant women have shown that while SP exhibits weaker effica
 cy against malaria compared to other more potent antimalarials\, SP demon
 strates superior efficacy against adverse birth outcomes\, suggesting SP’
 s effects extend beyond its antimalarial activity. In this talk\, Dr. Roh
  will describe the most plausible reason for this phenomenon and how caus
 al inference methods can be applied to: (1) understand the potential mech
 anisms underlying SP’s ‘non-malarial’ effect and (2) inform optimized reg
 imens for pregnant women and children in Africa. In countries nearing eli
 mination\, chemoprevention through mass drug administration (MDA) that ha
 s received renewed interest as a tool to accelerate moderate-to-low trans
 mission settings toward malaria elimination. Dr. Roh will describe her wo
 rk on a cluster randomized controlled trial in Senegal and future project
 s using trial data to inform optimally tailored campaigns and the next ph
 ase of targeted interventions after MDA.\n\nSpeaker:\nMichelle Roh\, PhD\
 n\nAdmission:\nFree\n\nFood:\nLunch\n\nDetails URL:\nhttps://medicine.yal
 e.edu/event/michelleroh/\n
DTEND;TZID=America/New_York:20230803T140000
DTSTAMP:20261009T043730Z
DTSTART;TZID=America/New_York:20230803T130000
GEO:41.303666;-72.932218
LOCATION:Yale School of Public Health (LEPH)\, 115\, 60 College Street\, N
 ew Haven\, CT\, United States
SEQUENCE:0
STATUS:Confirmed
SUMMARY:YSPH EMD Seminar: "Leveraging Causal Inference Methods to Optimize
  Chemoprevention Strategies for Malaria Control and Elimination"
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