Xiaoming Shi
Professor AdjunctCards
About
Research
Publications
2025
Evaluation of dried blood spot with inductively coupled plasma mass spectrometry for trace toxic elements measurement in human biomonitoring
Sun Q, Wang Y, Cui W, Yu X, Bai X, Qiu T, Lu Y, Shi X. Evaluation of dried blood spot with inductively coupled plasma mass spectrometry for trace toxic elements measurement in human biomonitoring. Microchemical Journal 2025, 217: 115100. DOI: 10.1016/j.microc.2025.115100.Peer-Reviewed Original ResearchMass spectrometryInductively coupled plasma mass spectrometryInter-batch precisionLow detection limitPlasma mass spectrometryMatrix-matched calibrationDried Blood SpotsICP-MSMatrix effectsSample extraction methodMatrix interferencesDetection limitSatisfactory intra-Excellent linearityInternal standardWorking curveHuman biomonitoringTrace element determinationHuman whole bloodSpectrometryBlood spotsNational human biomonitoring programElement determinationHuman biomonitoring programsField-deployable methodUrinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study
Li C, Guo X, Ren H, Xu Y, Fang J, Sun P, Ding E, Lu Y, Li C, Zhao X, Long K, Cao K, Qian J, Chen Y, Wang Y, Deng F, Hou M, Shi Y, Cai Y, Tong S, Shen T, Tang S, Shi X. Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study. Environment & Health 2025 DOI: 10.1021/envhealth.5c00050.Peer-Reviewed Original ResearchOlder adultsHealthy older adultsOrganophosphate estersAdverse health outcomesGeriatric diseasesDiphenyl phosphateQuantile g-computationGeneralized Additive Mixed ModelsExposure to organophosphate estersBayesian kernel machine regressionHealth hazardsHealth outcomesOPE exposureKernel machine regressionAdditive mixed modelsG-computationDibutyl phosphateBis(1,3-dichloro-2-propyl) phosphateAcute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China
Tian Y, Chen C, Li J, Liu S, Fang J, Zhao F, Tang S, Zhang Y, Du P, Wang J, Zhang Z, Li Y, Ding E, Liu Y, Wang F, Shi W, Sun Q, Hu J, Shi X. Acute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China. Ecotoxicology And Environmental Safety 2025, 303: 118976. PMID: 40925186, DOI: 10.1016/j.ecoenv.2025.118976.Peer-Reviewed Original ResearchConceptsImpacts of PM2.5Endocrine disrupting effectsBeijing-Tianjin-HebeiHeavy metalsAmbient fine particulate matterFine particulate matterAir pollutant concentrationsAssociated with thyroid hormone levelsThyroid hormone homeostasisPollutant concentrationsIQR increaseParticulate matterMonitoring stationsConstituent concentrationsParticulate constituentsThyroid homeostasisPbSurrounding areaMultiple linear regression modelZnHormone homeostasisThyroid hormone levelsMetalAssociated with T3CdAssociations of ambient particulate matter and nitrogen dioxide with hospital admissions for Parkinson's disease: A nationwide case-crossover study in China
Bai L, Jiang Y, Zhang K, Su H, Sun S, Deng F, Baccarelli A, Shi X, Guo X, Wu S. Associations of ambient particulate matter and nitrogen dioxide with hospital admissions for Parkinson's disease: A nationwide case-crossover study in China. Environmental Pollution 2025, 385: 127062. PMID: 40902708, DOI: 10.1016/j.envpol.2025.127062.Peer-Reviewed Original ResearchAssociation of PM2.5 wiAmbient particulate matterParticulate matterAir pollutionCo-exposureAssociation of ambient particulate matterCase-crossover studyNitrogen dioxideInterquartile range increaseLow concentration exposureHigh-concentration exposuresCoarse PMPD admissionsRange increasePrincipal discharge diagnosisPollutionHospital admissionPopulation-based evidenceHospital admission dataAssociated with increasesMedical insurance schemeMatterAirExposureDioxideAssociation of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study
Wang X, Zhong W, Chen Z, Song W, You F, Li Z, Lv Y, Liu D, Shi X, Mao C. Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study. American Journal Of Clinical Nutrition 2025 PMID: 40876539, DOI: 10.1016/j.ajcnut.2025.08.013.Peer-Reviewed Original ResearchWeight-adjusted waist indexAssociated with frailty riskBody roundness indexAdiposity markersFrailty riskOlder adultsProspective cohort studyFrailty indexCohort studyHigh frailty riskSerum 25-hydroxyvitamin DWaist indexRoundness indexSerum 25(OH)DBody shape indexAssociation of adiposityFollow-upBody mass indexFrailty preventionJoint associationsWaist circumferenceBiomarkers Cohort StudyHealth deficitsLinear mixed modelsLow serum 25(OH)DThe Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study
Yang J, Huang J, Huang Q, Gao J, Liu D, Li Z, Lv Y, Shi X, Mao C. The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study. JMIR Aging 2025, 8: e75942. PMID: 40795324, PMCID: PMC12342692, DOI: 10.2196/75942.Peer-Reviewed Original Research[Association of cadmium internal exposure levels with blood lipid in adults aged 18 to 79 years in China].
Song H, Ji S, Li Z, Li Y, Zhao F, Qu Y, Lu Y, Han Y, Liu J, Cai J, Qiu T, Zhang W, Lin X, Cai J, Lyu Y, Shi X. [Association of cadmium internal exposure levels with blood lipid in adults aged 18 to 79 years in China]. Chinese Preventive Medicine 2025, 59: 1254-1263. PMID: 40829911, DOI: 10.3760/cma.j.cn112150-20241016-00819.Peer-Reviewed Original ResearchConceptsMultiple linear mixed effects modelsGeneralized linear mixed effects modelsAssociation of bloodLipid profile levelsChinese adultsLinear mixed effects modelsBlood cadmium levelsMulti-stage stratified random sampling methodMixed effects modelsPrevalence ratesConclusion:Results:LDL-CCross-sectional surveyUrinary cadmium levelsTotal cholesterolHDL-CLipoprotein cholesterolLow HDL-CHigh LDL-CEffects modelPrevalence rates of hypercholesterolemiaHigh-density lipoprotein cholesterolRates of hypercholesterolemiaExposure groupUrinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks
Qian J, Guo X, Qi C, Sun P, Li C, Li C, Cao K, Xu Y, Ren H, Zhang J, Wang Y, Bao S, Qiu T, Wang C, Gu W, Lu Y, Tong S, Tang S, Shi X. Urinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks. Journal Of Hazardous Materials 2025, 496: 139444. PMID: 40773834, DOI: 10.1016/j.jhazmat.2025.139444.Peer-Reviewed Original ResearchConceptsPolycyclic aromatic hydrocarbonsHealth risksHazard indexOH-PAHsPAH exposureUrinary OH-PAH concentrationsDietary exposure routeNon-carcinogenic riskPolycyclic aromatic hydrocarbon exposureOH-PAH concentrationsHuman health risksHealth risk assessmentRisk assessmentCarcinogenic risk assessmentConsumption of drinking waterAromatic hydrocarbonsExposure routesPartial burningMitigation policiesMixed-effects modeling techniquesDrinking waterComprehensive exposureCorn productionShandong ProvinceCarbon-based materialsCombined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Zhong W, Wang X, Chen H, Song W, Gao J, Chen P, Shen Q, You F, Li C, Lv Y, Li Z, Shi X, Mao C. Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study. Alzheimer's Research & Therapy 2025, 17: 158. PMID: 40660329, PMCID: PMC12257734, DOI: 10.1186/s13195-025-01806-7.Peer-Reviewed Original ResearchConceptsCombined effects of physical activityEffects of physical activityPhysical activityApolipoprotein E genotypeRisk of cognitive impairmentHealthy dietHazard ratioCognitive impairmentOlder adultsDietary patternsActivity levelsLow risk of cognitive impairmentAdjusted Cox proportional hazards modelsMini-Mental State ExaminationNon-carriersOlder Chinese adultsApolipoprotein ELow riskCox proportional hazards modelsHigh PAProportional hazards modelDiet qualityCombination of activity levelMini-MentalChinese adultsAssociation between vegetarian diet and risk of frailty in Chinese older adults: a prospective study
Huang Y, Jigeer G, Lv Y, Wang K, Ma X, Zou J, Xia R, Shen X, Shi X, Li Y, Gao X. Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study. BMC Medicine 2025, 23: 352. PMID: 40598166, PMCID: PMC12211529, DOI: 10.1186/s12916-025-04232-6.Peer-Reviewed Original ResearchConceptsRisk of frailtyChinese older adultsOlder adultsAssociated with higher riskFrailty riskDiet trajectoriesIncident frailtyAssociated with higher risk of frailtyChinese community-dwelling older adultsMultivariable time-varying Cox proportional hazards modelsChinese Longitudinal Healthy Longevity SurveyPesco-vegetariansCommunity-dwelling older adultsHigher risk of frailtyHazard ratioTime-varying Cox proportional hazards modelsConfidence intervalsRisk of incident frailtyFree of frailtyFood frequency questionnaireVegetarian dietHigher risk of incident frailtyHigh riskCox proportional hazards modelsLongevity Survey