2025
Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study. Environmental Health 2025, 24: 48. PMID: 40652244, PMCID: PMC12255010, DOI: 10.1186/s12940-025-01199-y.Peer-Reviewed Original ResearchConceptsShort birth lengthAdverse birth outcomesBirth outcomesBirth lengthMulti-country cohort studyAntenatal care visitsAssociated with lower offspring birth weightParent-specific effectsPFAS exposureMaternal exposureBirth weightQuantile g-computationOffspring birth weightPrenatal PFAS exposureCare visitsResultsNo associationEffects of PFAS exposureG-computationLow birth weightCohort studyINUENDO cohortEffect sizeMedical recordsMethodsThis studyPaternal exposurePerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedA Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States
Campbell E, Koenig M, Mooney F, Clark C, González D, Deziel N, Casey J, Buonocore J, Willis M. A Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States. Current Environmental Health Reports 2025, 12: 21. PMID: 40263220, PMCID: PMC12308367, DOI: 10.1007/s40572-025-00485-8.Peer-Reviewed Original ResearchPaternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study. Environmental Science And Technology 2025, 59: 5973-5982. PMID: 40104843, DOI: 10.1021/acs.est.4c13040.Peer-Reviewed Original ResearchConceptsBehavioral difficultiesAssociated with internalizing difficultiesStrengths and Difficulties QuestionnaireChildren's behavioral difficultiesSex-specific mannerSex-specific cut-offsExternalizing difficultiesMaternal PFASWeeks of gestationParent-rated Strengths and Difficulties QuestionnairePrenatal PFAS exposurePaternal exposurePolyfluoroalkyl substancesDifficulties QuestionnaireChild sexOffspring neurodevelopmentAssociated with behavioral difficultiesPrenatal exposureAntenatal clinicMaternal prenatal exposureINUENDO cohortAged 5Maternal exposurePerfluorononanoic acidDevelopmental toxicityPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, PMCID: PMC11887085, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesDemographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York
Mooney F, Kelly J, Warren J, Deziel N. Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York. Health & Place 2025, 91: 103409. PMID: 39799904, PMCID: PMC11792615, DOI: 10.1016/j.healthplace.2024.103409.Peer-Reviewed Original ResearchConceptsLow-income residentsSuperfund siteEnvironmental burdenSocio-DemographicHigh PM2.5 concentrationsEnvironmental variablesCensus tractsLong IslandPoisson regression modelsBlack residentsCumulative environmental burdenDemographic inequalitiesNew YorkDistribution inequalitySuperfundCommunity demographicsHispanic/Latino residentsToxic releasesExposure potentialCounty residentsExposed communitiesStratified analysis
2024
Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review
Vohra V, Yesantharao L, Stemme R, Seal S, Morris-Wiseman L, McAdams-DeMarco M, Mady L, Deziel N, Biswal S, Ramanathan M, Mathur A. Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review. Thyroid 2024, 34: 1451-1464. PMID: 39552469, PMCID: PMC12394804, DOI: 10.1089/thy.2024.0317.Peer-Reviewed Original ResearchConceptsAir pollutionPolyaromatic hydrocarbonsEnvironmental air pollutionThyroid cancer diagnosisConcentrations of PM2.5Blood Institute quality assessment toolCancer diagnosisStudy designPollution assessment methodsSystematic reviewInclusion criteriaGlobal incidence of thyroid cancerOutdoor air pollutionQuality assessment toolMagnitude of associationIncidence of thyroid cancerRisk of biasQuality of evidencePollution levelsSystematic literature searchWeb of ScienceParticulate matterSpecific pollutantsLevels of COSOUsing a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Siddique S, Baum L, Deziel N, Kelly J, Warren J, Ma X. Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer. PLOS ONE 2024, 19: e0311540. PMID: 39471191, PMCID: PMC11521299, DOI: 10.1371/journal.pone.0311540.Peer-Reviewed Original ResearchConceptsAge-of-onset colorectal cancerEarly-onset colorectal cancerEnd Results program dataCenters for Disease Control and Prevention dataCounty-level factorsColorectal cancerHealth risk behaviorsIdentified principal componentsOdds of survivalPreventive servicesSurvival disparitiesLinear mixed modelsEOCRCChronic diseasesPreventive factorsUS countiesSalt Lake CountyCA residentsRisk behaviorsUnited StatesProgram dataCounty-levelOlder ageBayesian analytical approachYounger ageDelineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment
Song Y, Deziel N, Bell M. Delineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment. Environmental Science And Technology 2024, 58: 19178-19188. PMID: 39412270, PMCID: PMC11627196, DOI: 10.1021/acs.est.4c06942.Peer-Reviewed Original ResearchConceptsEnvironmental exposuresEnvironmental exposure assessmentExposure of particulate matterUrban/rural disparitiesDemographic compositionHealth StudyHealth researchPopulation-basedClassification systemExposure assessmentSpatial patternsHealth impactsRural areasHealthRuralParticulate matterLand surface temperatureWest VirginiaUnited StatesSurface temperatureUrbanizationResearch questionsAssessmentDisparitiesExposureResidential Proximity to Oil and Gas Development and Mental Health in a North American Preconception Cohort Study: 2013-2023.
Willis M, Campbell E, Selbe S, Koenig M, Gradus J, Nillni Y, Casey J, Deziel N, Hatch E, Wesselink A, Wise L. Residential Proximity to Oil and Gas Development and Mental Health in a North American Preconception Cohort Study: 2013-2023. American Journal Of Public Health 2024, 114: 923-934. PMID: 38991173, PMCID: PMC11306607, DOI: 10.2105/ajph.2024.307730.Peer-Reviewed Original ResearchConceptsPsychotropic medication usePreconception cohort studyPrevalence ratiosMental healthDepressive symptomsMedication useCohort studyProspective cohortNorth American preconception cohort studyConfidence intervalsMental health symptomatologyPregnancy Study OnlineLog-binomial regressionCohort of USSevere depressive symptomsRestricted cubic splinesCross-sectional dataHealth symptomatologyPerceived stressCanadian womenPregnancy plannersBaseline dataCubic splinesHealthPreconceptionHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyNitrate exposure from drinking water and dietary sources among Iowa farmers using private wells
Skalaban T, Thompson D, Madrigal J, Blount B, Espinosa M, Kolpin D, Deziel N, Jones R, Beane Freeman L, Hofmann J, Ward M. Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells. The Science Of The Total Environment 2024, 919: 170922. PMID: 38350573, PMCID: PMC11665930, DOI: 10.1016/j.scitotenv.2024.170922.Peer-Reviewed Original ResearchConceptsMaximum contaminant levelUrinary nitrate concentrationDietary intakeNitrate concentrationsNitrate excretionNitrate exposureDietary nitrateDrinking waterDietary assessment toolsPrivate wellsAssociated with adverse health risksVulnerable to nitrate contaminationWater nitrate concentrationsNitrate ingestionAdverse health risksAgricultural Health StudyDrinking water intakeMedian intakeProspective cohortUrinary nitrateDietary nitrate ingestionContamination levelsNitrate contaminationNitrate intakeHealth StudyAssessing exposure and health consequences of chemicals in drinking water in the 21st Century
Deziel N, Villanueva C. Assessing exposure and health consequences of chemicals in drinking water in the 21st Century. Journal Of Exposure Science & Environmental Epidemiology 2024, 34: 1-2. PMID: 38429481, DOI: 10.1038/s41370-024-00639-0.Peer-Reviewed Original ResearchDrinking WaterHumans
2023
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryUrinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samplesResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metricsHealth risks of heavy metals in food and their economic burden in Armenia
Pipoyan D, Stepanyan S, Beglaryan M, Stepanyan S, Mendelsohn R, Deziel N. Health risks of heavy metals in food and their economic burden in Armenia. Environment International 2023, 172: 107794. PMID: 36758298, DOI: 10.1016/j.envint.2023.107794.Peer-Reviewed Original ResearchConceptsHeavy metal intakeBenchmark dose levelsBlood pressureLead exposureEconomic burdenDose levelsDietary exposureEuropean Food Safety AuthorityAdverse health impactsDiet surveyDaily intakeExcess exposureConsumer safety concernsFood Safety AuthorityHealth impactsHealth risksSafety concernsIntakeLower IQ levelsExposureSpecific pathwaysExposure valuesSafety AuthorityPopulationMetal intake
2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive functionHemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study
Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.Peer-Reviewed Original ResearchUnconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOdds
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