2025
Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study. Environmental Science And Technology 2025, 59: 5973-5982. PMID: 40104843, DOI: 10.1021/acs.est.4c13040.Peer-Reviewed Original ResearchConceptsBehavioral difficultiesAssociated with internalizing difficultiesStrengths and Difficulties QuestionnaireChildren's behavioral difficultiesSex-specific mannerSex-specific cut-offsExternalizing difficultiesMaternal PFASWeeks of gestationParent-rated Strengths and Difficulties QuestionnairePrenatal PFAS exposurePaternal exposurePolyfluoroalkyl substancesDifficulties QuestionnaireChild sexOffspring neurodevelopmentAssociated with behavioral difficultiesPrenatal exposureAntenatal clinicMaternal prenatal exposureINUENDO cohortAged 5Maternal exposurePerfluorononanoic acidDevelopmental toxicity
2020
Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasma
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