2025
Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, Schwab A, Edwards D, Taylor H, Wenner M. Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women. AJP Heart And Circulatory Physiology 2025, 328: h327-h332. PMID: 39773019, PMCID: PMC12175985, DOI: 10.1152/ajpheart.00815.2024.Peer-Reviewed Original ResearchConceptsPostmenopausal womenExogenous estradiol administrationEndothelin B receptorEstradiol administrationPremenopausal womenLactated RingeHealthy postmenopausal womenYoung womenLaser Doppler flowmetryEndothelin-BVasodilatory responseTransdermal patchDoppler flowmetryCutaneous microcirculationVasodilationEstradiolAdministrationWomenReceptorsRingerBlockadeFlowmetry
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultEstradiolFemaleGenisteinHumansInsulin ResistanceMicrocirculationMicrovesselsVasodilationConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusion
2011
Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome
Wenner MM, Taylor HS, Stachenfeld NS. Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. The Journal Of Physiology 2011, 589: 4671-4679. PMID: 21825025, PMCID: PMC3213415, DOI: 10.1113/jphysiol.2011.216218.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesEndothelin A Receptor AntagonistsEndothelin B Receptor AntagonistsEndothelin-1Endothelin-2Endothelium, VascularFemaleHumansMicrocirculationMicrovesselsOligopeptidesPeptides, CyclicPiperidinesPolycystic Ovary SyndromeReceptor, Endothelin AReceptor, Endothelin BRegional Blood FlowSkinVasoconstrictionVasodilationYoung AdultConceptsPolycystic ovary syndromeET-B receptorsLocal skin warmingOvary syndromeSkin warmingLower vascular reactivityPeripheral microvascular functionLaser Doppler flowmetrySkin blood flowGroup of womenDose-response curveBlunted responsivenessEndothelin BEndothelin AEndothelial dysfunctionVascular reactivityVasoconstrictive responseVasodilatory responseMicrovascular functionCutaneous microvasculatureIntradermal microdialysisAntagonist infusionEndothelin-1Receptor responsivenessReceptor subtypes
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