2025
Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson J, Siblini H, Al‐Hendy A, Segars J, González F, Taylor H, Singh B, Carson S, Christman G, Huang H, Dangi B, Zhang H. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. Clinical And Translational Science 2025, 18: e70189. PMID: 40077973, PMCID: PMC11903501, DOI: 10.1111/cts.70189.Peer-Reviewed Original ResearchConceptsEpigallocatechin-3-gallateFolate levelsUterine fibroidsClinical trialsGreen tea extractAssociated with folate deficiencyPresence of MTHFRWomen of Childbearing AgeSerum folate levelsReduced folate levelsActive clinical trialsReproductive-age womenEffect of epigallocatechin gallateDHFR genotypeDHFR polymorphismTea extractDaily doseClomiphene citrateUnexplained infertilityFolate deficiencyChildbearing ageClinical studiesTreated womenFibroidsLetrozole
2019
Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study
D'Hooghe TM, Grechukhina O, Cho S, Fassbender A, O D, Peterse D, Weidhaas J, Taylor HS. Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study. Gynecologic And Obstetric Investigation 2019, 84: 575-582. PMID: 31185482, DOI: 10.1159/000500626.Peer-Reviewed Original ResearchConceptsCase-control studyGerm-line single nucleotide polymorphismsKRAS geneLarge case-control studyReproductive-age womenType of infertilityBody mass indexEuropean case-control studyKRAS 3' untranslated regionLarge European case-control studyMicroRNA-binding sitesMedical therapyPeritoneal biopsiesMass indexPeripheral bloodAge womenPolymerase chain reactionCommon disorderTreatment resistanceEndometriosisCarrier rateVariant allelesCaucasian populationGene variantsKRAS allele
2013
Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance
Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam GR, Wharton W, Naftolin F, Taylor H, Harman SM, Asthana S. Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance. PLOS ONE 2013, 8: e68741. PMID: 23874743, PMCID: PMC3714288, DOI: 10.1371/journal.pone.0068741.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyLow-risk classPostmenopausal womenCV risk factor profileDisease riskApolipoprotein E (APOE) ε4 alleleCV risk classificationCV risk profileHigh-risk womenRisk factor profileCV disease riskVascular disease riskLast menstrual periodConsiderable interindividual variabilityEducation levelHigh-risk classCV diseaseCV riskCardiovascular riskMenopausal womenMenstrual periodPrevention StudyPreclinical diseasePreventive strategiesTreatment decisionsMedical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Obstetrics And Gynecology 2013, 65: 199-213. PMID: 23598784, PMCID: PMC3718308.Peer-Reviewed Original ResearchConceptsPeritoneal microenvironmentMedical managementDisease pathophysiologyEndometrial progesterone resistanceAppropriate medical managementPathogenesis of endometriosisProgesterone-responsive genesNew therapeutic targetsDisease developmentFemale reproductive tractProgesterone resistanceProinflammatory processesEutopic endometriumRisk factorsProgesterone actionPatients exhibitTherapeutic targetEndometriosisReproductive tractProtein expressionNovel mechanistic frameworkEndometriumInflammationPathophysiologyDisease establishment
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