2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometriumStem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2024
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
2022
ENDOCELL-Seud: a Delphi protocol to harmonise methods in endometrial cell culturing
Romano A, Guo SW, Brosens J, Fazlebas A, Gargett C, Giselbrecht S, Gotte M, Griffith L, Taylor HS, Taylor RN, Vankelecom H, Chapron C, Chang X, Khan KN, Vigano’ P. ENDOCELL-Seud: a Delphi protocol to harmonise methods in endometrial cell culturing. Reproduction And Fertility 2022, 3: g1-g8. PMID: 35972317, PMCID: PMC9422235, DOI: 10.1530/raf-22-0041.Peer-Reviewed Original ResearchUterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy
Taylor HS. Uterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy. Molecular Therapy 2022, 30: 1357-1358. PMID: 35320748, PMCID: PMC9077366, DOI: 10.1016/j.ymthe.2022.03.007.Peer-Reviewed Original ResearchMeSH KeywordsDeciduaEndometriumFemaleHomeodomain ProteinsHumansPregnancyRNA, Long NoncodingTranscription FactorsUterusConceptsPregnancy
2021
Obesity and reproduction: a committee opinion
Medicine P, Penzias A, Azziz R, Bendikson K, Falcone T, Hansen K, Hill M, Jindal S, Kalra S, Mersereau J, Reindollar R, Shannon C, Steiner A, Tanrikut C, Taylor H, Yauger B. Obesity and reproduction: a committee opinion. Fertility And Sterility 2021, 116: 1266-1285. PMID: 34583840, DOI: 10.1016/j.fertnstert.2021.08.018.Peer-Reviewed Original Research
2020
Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells. Reproductive Sciences 2020, 28: 426-434. PMID: 32812213, DOI: 10.1007/s43032-020-00294-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCDC2 Protein KinaseCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLParacrine CommunicationSignal TransductionStromal CellsConceptsBone marrow-derived stem cellsCell proliferationEndometrial cellsEstrogen-dependent gynecological disorderPrimary endometrial stromal cellsEndometrial stromal cell proliferationEndometriosis cell proliferationReproductive-aged womenEndometrial stromal cellsNormal endometrial cellsEndometrial cell proliferationMarrow-derived stem cellsNovel therapeutic strategiesStromal cell proliferationBone marrow mesenchymal stem cellsStem cellsSignificant clonal expansionMarrow mesenchymal stem cellsPelvic painEndometriotic lesionsEndometriosis growthGynecological disordersEndometriosis cell linesMouse modelEndometriosisMenstruation: science and society
Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim JJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor HS, Wagner GP, Griffith LG. Menstruation: science and society. American Journal Of Obstetrics And Gynecology 2020, 223: 624-664. PMID: 32707266, PMCID: PMC7661839, DOI: 10.1016/j.ajog.2020.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenomyosisAttitudeBiological EvolutionBiomedical ResearchCongresses as TopicDeveloping CountriesEducationEndometriosisEndometriumFemaleGlobal HealthHealth LiteracyHumansLeiomyomaMenstrual Hygiene ProductsMenstruationMenstruation DisturbancesMesenchymal Stem CellsMicrobiotaMicrofluidic Analytical TechniquesNational Institute of Child Health and Human Development (U.S.)RegenerationStem CellsTerminology as TopicTissue EngineeringUnited StatesUterine HemorrhageUterine NeoplasmsUterusWomen's HealthConceptsAbnormal uterine bleedingMenstruation-related disordersUterine bleedingEunice Kennedy Shriver National InstituteHealth concernScarless healing processWomen's health concernsMenstrual healthGynecologic healthUterine preservationMiddle-income countriesProgesterone withdrawalVascular functionClinical challengeHigh-income countriesEndometrial biologyChild healthHealth literacyMost womenHealthy individualsMenstrual physiologyOverall healthReproductive healthDisease BranchMenstruationEndometriosis: The Role of Iron Overload and Ferroptosis
Ng SW, Norwitz SG, Taylor HS, Norwitz ER. Endometriosis: The Role of Iron Overload and Ferroptosis. Reproductive Sciences 2020, 27: 1383-1390. PMID: 32077077, DOI: 10.1007/s43032-020-00164-z.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsIron overloadRetrograde menstruationEndometrial tissueSubsequent pathophysiologyEutopic endometriumRisk factorsAbdominal cavityWomen's healthReproductive disordersIron deficiencyEndometriosisSuch disordersLesionsIron excessPrimary defectEctopic sitesCholesterol biosynthetic pathwayNon-apoptotic programmed cell deathCell survivalCell deathIron homeostasisDisordersFerroptosisOverloadTherapeutic endometrial regeneration: clinical application of bone marrow‐derived stem cells
Taylor H. Therapeutic endometrial regeneration: clinical application of bone marrow‐derived stem cells. BJOG An International Journal Of Obstetrics & Gynaecology 2020, 127: 561-561. PMID: 31925867, DOI: 10.1111/1471-0528.16088.Peer-Reviewed Original ResearchCXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, Taylor HS. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. Journal Of Cellular And Molecular Medicine 2020, 24: 2464-2474. PMID: 31904910, PMCID: PMC7028867, DOI: 10.1111/jcmm.14933.Peer-Reviewed Original ResearchConceptsCXCR7 antagonistLesion sizePro-inflammatory cytokine productionBone marrow-derived cellsNon-hormonal therapiesMouse bone marrow transplantation modelBone marrow transplantation modelBone marrow cell migrationMarrow-derived cellsProgression of endometriosisEndometriosis implantsEndometrial effectsAntagonist treatmentEndometriotic lesionsCytokine productionEndometrial physiologyStem cell recruitmentEutopic endometriumTransplantation modelCell recruitmentNull miceCell traffickingEndometriosisEpithelial cell fateCXCR4
2019
Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency
Reig A, Mamillapalli R, Coolidge A, Johnson J, Taylor HS. Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency. Reproductive Sciences 2019, 26: 1633-1639. PMID: 31530098, PMCID: PMC6949960, DOI: 10.1177/1933719119875818.Peer-Reviewed Original ResearchConceptsEndometrial mesenchymal stem cellsPrimary ovarian insufficiencyOvarian functionOvarian insufficiencyMurine modelSerum anti-Müllerian hormone concentrationsAnti-Müllerian hormone concentrationsStem cellsStem cell therapyOvarian dysfunctionUterine cell suspensionsHormone concentrationsMesenchymal stem cellsUterine cellsChemotherapyYoung womenCell therapyMiceOocyte poolIncreased numberWomenHigher body massSignificant increaseInsufficiencyPupsDose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model
Rosa-e-Silva ACJS, Rosa-e-Silva JC, Mamillapalli R, Taylor HS. Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model. Reproductive Sciences 2019, 26: 1395-1400. PMID: 31274059, PMCID: PMC6949971, DOI: 10.1177/1933719119859438.Peer-Reviewed Original ResearchConceptsMurine modelCurrent clinical staging systemBurden of endometriosisClinical staging systemClear dose-response relationshipDegree of painStage of diseaseEffect of endometriosisMechanism of infertilityGroups of miceSequelae of diseaseSeverity of symptomsDose-response relationshipSham surgery controlsActive diseaseDisease activityPelvic painStaging systemEarly recognitionEctopic tissueEndometrial cellsGynecological diseasesSurgery controlsPregnancy rateUterine tissuePotential roles of aquaporin 9 in the pathogenesis of endometriosis
Choi YS, Park JH, Yoon JK, Yoon JS, Kim JS, Lee JH, Yun BH, Park JH, Seo SK, Cho S, Lee BS, Taylor HS. Potential roles of aquaporin 9 in the pathogenesis of endometriosis. Molecular Human Reproduction 2019, 25: 373-384. PMID: 31070762, DOI: 10.1093/molehr/gaz025.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsPathogenesis of endometriosisEndometrial stromal cellsPotential therapeutic targetExpression of MMP2P38 MAPK proteinWestern blot analysisControl patientsEndometrial expressionPhosphorylated ERK 1/2Ectopic endometriumEutopic endometriumInflammatory processLaparoscopic surgeryEndometriosisTherapeutic targetBenign conditionsAQP subtypesExpression of AQP9Stromal cellsTumor developmentWestern blottingAQP9 expressionHealing assaysERK 1/2CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMiceEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEndometriosisEndometriumFemaleMenstruation DisturbancesMiceMice, Inbred C57BLConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesionsMicroRNAs in endometriosis: biological function and emerging biomarker candidates†
Bjorkman S, Taylor HS. MicroRNAs in endometriosis: biological function and emerging biomarker candidates†. Biology Of Reproduction 2019, 101: 1167-1178. PMID: 30721951, PMCID: PMC6497525, DOI: 10.1093/biolre/ioz014.Peer-Reviewed Original ResearchConceptsChronic diseasesReproductive-aged womenCommon chronic diseasesPathophysiology of endometriosisDisease-specific pathophysiologyRole of tissuePelvic painEndometriosis treatmentEndometriosisCandidate biomarkersPotential biomarkersNoninvasive toolSmall noncoding RNA moleculesDiseaseBiomarkersMultiple studiesPrecision medicineKey post-transcriptional regulatorsPathophysiologyNoncoding RNA moleculesMiRNA biomarkersDiagnosisMiRNA expressionFunctional pathwaysSpecific miRNAsResponse to Letter to the Editor: “Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis”
Flores VA, Vanhie A, Dang T, Taylor HS. Response to Letter to the Editor: “Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis”. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 2149-2149. PMID: 30657936, PMCID: PMC7296127, DOI: 10.1210/jc.2018-02712.Peer-Reviewed Original Research
2018
Reply: Bone marrow-derived endometrial cells: what you see is what you get
Santamaria X, Mas A, Cervelló I, Taylor HS, Simon C. Reply: Bone marrow-derived endometrial cells: what you see is what you get. Human Reproduction Update 2018, 25: 274-275. PMID: 30601981, DOI: 10.1093/humupd/dmy042.Peer-Reviewed Original ResearchProgesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis
Flores VA, Vanhie A, Dang T, Taylor HS. Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4561-4568. PMID: 30357380, PMCID: PMC6226602, DOI: 10.1210/jc.2018-01227.Peer-Reviewed Original ResearchConceptsProgestin-based therapyPR statusReceptor statusEndometriotic lesionsPredictive valueEndometriosis-associated painProgesterone receptor levelsRetrospective cohort studyFirst-line treatmentProgesterone receptor statusNegative predictive valuePositive predictive valueElectronic medical recordsRabbit polyclonal IgGPrecision-based approachesProgestin therapyHormonal therapyEndometriosis treatmentCohort studyPredictive markerMedical recordsReceptor levelsH-scoreAcademic centersEndometriosis
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