2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell LineCell ProliferationEndometriosisEndometriumFemaleHomeodomain ProteinsHumansProgestinsRNA, Long NoncodingConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometriumQuinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial
Pellicer A, Taylor H, Alberich-Bayarri A, Liu Y, Gamborg M, Barletta K, Pinton P, Heiser P, Bagger Y. Quinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2025, 310: 113946. PMID: 40188683, DOI: 10.1016/j.ejogrb.2025.113946.Peer-Reviewed Original ResearchConceptsDeep infiltrating endometriosisVaginal ringNo significant differenceLesion sizeBleeding patternsMenstrual cycleSignificant differenceImaging biomarkersSerum prolactin levelsPhase 2 trialMenstrual bleeding patternsEndpoint of reductionPatient-reported outcomesHigh-resolution MRIInfiltrating endometriosisPlacebo groupDouble-blindPlacebo-controlledAdvanced diseaseEndometriotic lesionsPrimary endpointPain reductionSecondary endpointsProlactin levelsAdverse events
2024
A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis
Canis M, Abbott J, Abrao M, Al-Jefout M, Bedaiwy M, Benagiano G, Burns K, Canis M, Carmona F, Chapron C, Critchley H, de Ziegler D, Falcone T, Fazleabas A, Ferrero S, Garcia-Velasco J, Gargett C, Greaves E, Griffith L, Guo S, Habiba M, Harada T, Hull M, Johnson N, Kaufman Y, Issacson K, Khan K, Kim M, Koninckx P, Lessey B, Martin D, Matsuzaki S, Mishra G, Osuga Y, Petraglia F, Popov A, Roman H, Romano A, Saunders P, Seckin T, Somigliana E, Taylor H, Taylor R, Vercellini P, Vigano P. A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis. Journal Of Minimally Invasive Gynecology 2024, 31: 371-377. PMID: 38365066, DOI: 10.1016/j.jmig.2024.02.004.Peer-Reviewed Original Research
2023
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
Koller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyDepressionEndometriosisFeeding and Eating DisordersFemaleGenome-Wide Association StudyHumansConceptsPsychiatric comorbidityMAIN OUTCOMEMental healthIrritable bowel syndromeBody mass indexAssociation of endometriosisOdds of depressionSevere physical symptomsPain-related phenotypesWomen's mental healthMultivariate regression analysisOdds of endometriosisBowel syndromeGenetic associationMass indexGynecologic pathologyMillion Veteran ProgramEndometriosisPsychiatric disordersWomen's healthFemale controlsPleiotropic mechanismsPhysical symptomsComorbiditiesFinnGen study
2022
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina G, Taylor H. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Frontiers In Endocrinology 2022, 13: 1020827. PMID: 36387918, PMCID: PMC9643365, DOI: 10.3389/fendo.2022.1020827.Peer-Reviewed Original ResearchMeSH KeywordsCausalityEndometriosisFemaleHumansInfertility, FemaleOvarian ReserveReproductive Techniques, AssistedConceptsEndometriosis-associated infertilityRole of surgeryCurrent treatment optionsNon-invasive diagnostic toolLevel of impairmentInfertile womenRelated infertilityEndometrial receptivitySystemic diseaseTreatment optionsClinical managementDysfunctional alterationsEndometriosisSystemic effectsClinical situationsInfertilityPelvic anatomyClinical settingEndometriosis subtypesPrecise diagnosisPatient phenotypesReproductive technologiesDiagnostic toolTreatmentPhenotypeUterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis
Rosa-E-Silva ACJS, Mamillapalli R, Rosa-E-Silva JC, Ucar A, Schwartz J, Taylor HS. Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis. F&S Science 2022, 4: 65-73. PMID: 36252793, DOI: 10.1016/j.xfss.2022.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokinesEndometriosisFemaleHumansInfertility, FemaleIntegrinsLigandsMicePregnancyReceptors, ProgesteroneConceptsC motif chemokine ligand 12Endometriosis groupPregnancy rateChemokine ligand 12Alpha v beta 3 integrinUterine injectionBeta 3 integrinBMDC recruitmentProgesterone receptorMouse modelBone marrow-derived cell recruitmentHigher cumulative pregnancy rateLigand 12Therapeutic agentsEndometrial receptivity defectsCumulative pregnancy rateEndometrial receptivity markersSham surgery groupBone marrow transplantationLower pregnancy ratesAcademic medical centerPotential therapeutic agentReceptivity markersSurgery groupInduced endometriosisEndometriosis causes cardiovascular disease
Mamillapalli R, Taylor HS. Endometriosis causes cardiovascular disease. American Journal Of Obstetrics And Gynecology 2022, 227: 671. PMID: 35764140, DOI: 10.1016/j.ajog.2022.06.037.Peer-Reviewed Original ResearchPre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Taylor H, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open 2022, 12: e052043. PMID: 35715184, PMCID: PMC9207753, DOI: 10.1136/bmjopen-2021-052043.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityPlacebo-controlled trialGnRH antagonistFertility treatmentOral GnRH antagonistEndometriosis-related infertilityFertilization-embryo transferLive birth rateUse of gonadotropinsEtiology of infertilityInstitutional review boardAntagonist pretreatmentCommon complicationObstetrical outcomesPeer-reviewed journalsSecondary outcomesIVF treatmentPrimary outcomeHormone agonistImplantation ratePregnancy rateLive birthsEndometriosisLocal protocolsOocyte numberMethylation of microribonucleic acid Let-7b regulatory regions in endometriosis
Meixell DA, Mamillapalli R, Taylor HS. Methylation of microribonucleic acid Let-7b regulatory regions in endometriosis. F&S Science 2022, 3: 197-203. PMID: 35560017, DOI: 10.1016/j.xfss.2022.03.001.Peer-Reviewed Original ResearchEndometriosis promotes atherosclerosis in a murine model
Mamillapalli R, Toffoloni N, Habata S, Qunhua H, Atwani R, Stachenfeld N, Taylor HS. Endometriosis promotes atherosclerosis in a murine model. American Journal Of Obstetrics And Gynecology 2022, 227: 248.e1-248.e8. PMID: 35351413, PMCID: PMC9308711, DOI: 10.1016/j.ajog.2022.03.040.Peer-Reviewed Original ResearchConceptsEffect of endometriosisOil Red O stainingVascular endothelial growth factorMurine modelCardiovascular diseaseRed O stainingEndothelial growth factorSham miceEndometriotic lesionsInflammatory cytokinesInterleukin-6Luminal areaInterferon gammaO stainingGrowth factorAortic luminal areasInflammatory-related cytokinesRoot wall thicknessUnderwent sham surgeryTreatment of endometriosisInflammation-related cytokinesDevelopment of atherosclerosisApolipoprotein E (ApoE<sup>-/-</sup>) miceLong-term riskWeeks of induction
2021
Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation
Pretzel S, Kuhn K, Pal L, Polotsky A, Taylor HS, Zhang H, Robins J, Young SL, Santoro N. Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation. Reproductive Sciences 2021, 29: 620-626. PMID: 34363198, PMCID: PMC8345905, DOI: 10.1007/s43032-021-00705-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChoice BehaviorCOVID-19Double-Blind MethodElectronic Health RecordsEndometriosisFemaleFertility Agents, FemaleFertilization in VitroGonadotropin-Releasing HormoneHealth Knowledge, Attitudes, PracticeHormone AntagonistsHumansInfertility, FemaleLive BirthPatient SelectionPregnancyPregnancy RateResearch SubjectsTreatment OutcomeUnited StatesYoung AdultConceptsGnRH antagonistClinical trialsEndometriosis diagnosisSuperior live birth ratesCOVID-19Relevant ICD-10 codesOral GnRH antagonistLive birth rateAge-eligible womenICD-10 codesElectronic medical recordsSurvey of womenIVF cyclesEligible womenWillingness of womenInfertility diagnosisMedical recordsFertility treatmentIVFWomenDiagnosisTrialsBirth rateTreatmentCOVID-19 pandemicActivation of Hypocretin Neurons in Endometriosis
Mamillapalli R, Dang T, Habata S, Gao XB, Taylor HS. Activation of Hypocretin Neurons in Endometriosis. Reproductive Sciences 2021, 29: 243-249. PMID: 34279849, DOI: 10.1007/s43032-021-00682-4.Peer-Reviewed Original ResearchConceptsBody mass indexCAMP-responsive element binding proteinBody weightLower body mass indexNeuronal systemsHypocretin/orexin neuronsBehavioral changesPrevious murine studiesHigh-fat dietExpression of phosphorylationOrexin activitySham miceOrexin neuronsPain sensitizationGynecologic symptomsHypocretin neuronsMass indexHcrt cellsEndometriosis miceFat dietLateral hypothalamusPain perceptionReproductive ageGynecological diseasesMurine studiesReductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients
Abrao MS, Surrey E, Gordon K, Snabes MC, Wang H, Ijacu H, Taylor HS. Reductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients. BMC Women's Health 2021, 21: 246. PMID: 34134684, PMCID: PMC8210385, DOI: 10.1186/s12905-021-01385-3.Peer-Reviewed Original ResearchMeSH KeywordsDysmenorrheaEndometriosisFemaleHumansHydrocarbons, FluorinatedPelvic PainPyrimidinesQuality of LifeConceptsNon-menstrual pelvic painEndometriosis-associated painBaseline characteristicsSubgroup interactionsEndometriosis Health Profile-30Severe endometriosis-associated painGonadotropin-releasing hormone receptor antagonistEfficacy of elagolixPatient-reported reductionsPhase 3 studyHealth-related qualityReal-world patientsHormone receptor antagonistSubgroup of womenSignificant treatmentPercentage of womenAnalgesic usePelvic painMonth 3Receptor antagonistPrevious historyMost subgroupsPainPatient typesEndometriosis diseaseLoss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration
Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationEndometriosisEpithelial CellsFemaleIntraepithelial LymphocytesMiceReceptors, CXCR4ConceptsEndometriosis lesionsEpithelial compartmentLesion numberDisruption of CXCR4Intraepithelial lymphocyte infiltrationAdult female miceLoss of CXCR4CXCL12-CXCR4 axisTotal lesion areaProgesterone receptor promoterEndometriosis inductionLymphocyte infiltrationCXCR4 expressionFemale miceHost miceControl lesionsProestrus stageEpithelial proliferationImmune evasionCXCR4LesionsTherapeutic potentialLesion areaReduces ProliferationEpithelial cellsReimagining Endometriosis
Taylor HS. Reimagining Endometriosis. Med 2021, 2: 481-485. PMID: 35590229, DOI: 10.1016/j.medj.2021.04.026.Peer-Reviewed Original ResearchTofacitinib alters STAT3 signaling and leads to endometriosis lesion regression
Kotlyar AM, Mamillapalli R, Flores VA, Taylor HS. Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression. Molecular Human Reproduction 2021, 27: gaab016. PMID: 33693775, PMCID: PMC8454207, DOI: 10.1093/molehr/gaab016.Peer-Reviewed Original ResearchConceptsLesion regressionIshikawa cellsJAK/STATGrowth factor mRNA levelsEffects of tofacitinibTreatment of endometriosisHypoxia-inducible factor-1αVascular endothelial growth factor (VEGF) mRNA levelsFactor mRNA levelsWidespread clinical useWestern blot analysisVehicle treatmentOral gavageGynecologic conditionsC57BL/6 miceEutopic endometriumJanus kinase/signal transducerReproductive ageEndometriosisJAK inhibitorsKinase/signal transducerTofacitinibTherapeutic targetLesion growthClinical useEndometriosis is a chronic systemic disease: clinical challenges and novel innovations
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet 2021, 397: 839-852. PMID: 33640070, DOI: 10.1016/s0140-6736(21)00389-5.Peer-Reviewed Original ResearchConceptsSystemic diseaseGynaecological diseaseOral gonadotropin-releasing hormone antagonistClinical diagnosisLow-dose oral contraceptivesGonadotropin-releasing hormone antagonistEndometrial-like tissueChronic systemic diseaseFirst-line medicationAccurate clinical diagnosisFemale reproductive tractPain sensitisationOral contraceptivesPrompt treatmentSystemic inflammationGnRH antagonistProgesterone resistanceSymptomatic womenClinical presentationRetrograde menstruationEndometriosis careHormone antagonistReproductive ageEffective therapyTherapeutic alternativeEndometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2020
Emerging therapies for endometriosis
Taylor HS. Emerging therapies for endometriosis. Fertility And Sterility 2020, 115: 317-318. PMID: 33386111, DOI: 10.1016/j.fertnstert.2020.11.005.Peer-Reviewed Original ResearchResponsiveness and thresholds for clinically meaningful changes in worst pain numerical rating scale for dysmenorrhea and nonmenstrual pelvic pain in women with moderate to severe endometriosis
Pokrzywinski RM, Soliman AM, Snabes MC, Chen J, Taylor HS, Coyne KS. Responsiveness and thresholds for clinically meaningful changes in worst pain numerical rating scale for dysmenorrhea and nonmenstrual pelvic pain in women with moderate to severe endometriosis. Fertility And Sterility 2020, 115: 423-430. PMID: 33066973, DOI: 10.1016/j.fertnstert.2020.07.013.Peer-Reviewed Original ResearchConceptsSevere endometriosis-associated painEndometriosis-associated painNumerical rating scaleNonmenstrual pelvic painPelvic painWorst painMonth 3Rating ScalePain numerical rating scaleMeaningful changePremenopausal womenSevere endometriosisGlobal ImpressionClinical trialsMAIN OUTCOMEPainDysmenorrheaPhase IIIWomenElagolixResponsivenessTrialsPlaceboEndometriosisPatients
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