2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndometriumFemaleHumansMesenchymal Stem CellsPregnancyReproductionStem Cell TransplantationStem CellsConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2024
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchMeSH KeywordsBone Marrow CellsCell DifferentiationCell ProliferationEndometriumExosomesFemaleFibroblastsHumansMesenchymal Stem CellsMicroRNAsRegenerationConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
2021
Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2020
Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells. Reproductive Sciences 2020, 28: 426-434. PMID: 32812213, DOI: 10.1007/s43032-020-00294-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCDC2 Protein KinaseCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLParacrine CommunicationSignal TransductionStromal CellsConceptsBone marrow-derived stem cellsCell proliferationEndometrial cellsEstrogen-dependent gynecological disorderPrimary endometrial stromal cellsEndometrial stromal cell proliferationEndometriosis cell proliferationReproductive-aged womenEndometrial stromal cellsNormal endometrial cellsEndometrial cell proliferationMarrow-derived stem cellsNovel therapeutic strategiesStromal cell proliferationBone marrow mesenchymal stem cellsStem cellsSignificant clonal expansionMarrow mesenchymal stem cellsPelvic painEndometriotic lesionsEndometriosis growthGynecological disordersEndometriosis cell linesMouse modelEndometriosisMenstruation: science and society
Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim JJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor HS, Wagner GP, Griffith LG. Menstruation: science and society. American Journal Of Obstetrics And Gynecology 2020, 223: 624-664. PMID: 32707266, PMCID: PMC7661839, DOI: 10.1016/j.ajog.2020.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenomyosisAttitudeBiological EvolutionBiomedical ResearchCongresses as TopicDeveloping CountriesEducationEndometriosisEndometriumFemaleGlobal HealthHealth LiteracyHumansLeiomyomaMenstrual Hygiene ProductsMenstruationMenstruation DisturbancesMesenchymal Stem CellsMicrobiotaMicrofluidic Analytical TechniquesNational Institute of Child Health and Human Development (U.S.)RegenerationStem CellsTerminology as TopicTissue EngineeringUnited StatesUterine HemorrhageUterine NeoplasmsUterusWomen's HealthConceptsAbnormal uterine bleedingMenstruation-related disordersUterine bleedingEunice Kennedy Shriver National InstituteHealth concernScarless healing processWomen's health concernsMenstrual healthGynecologic healthUterine preservationMiddle-income countriesProgesterone withdrawalVascular functionClinical challengeHigh-income countriesEndometrial biologyChild healthHealth literacyMost womenHealthy individualsMenstrual physiologyOverall healthReproductive healthDisease BranchMenstruation
2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsDeciduaEmbryo ImplantationFemaleHomeodomain ProteinsMaleMesenchymal Stem CellsMice, KnockoutPregnancyConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2018
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
Li F, Alderman MH, Tal A, Mamillapalli R, Coolidge A, Hufnagel D, Wang Z, Neisani E, Gidicsin S, Krikun G, Taylor HS. Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 2018, 36: 881-890. PMID: 29450941, PMCID: PMC5992028, DOI: 10.1002/stem.2804.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell DifferentiationDisease Models, AnimalEndometriosisFemaleHumansMesenchymal Stem CellsMiceMiddle AgedSignal TransductionYoung AdultConceptsSerum CXCL12 levelsCXCL12 levelsEndometrial tissueEndometriosis lesionsHematogenous disseminationMesenchymal stem cell biomarkersCXCL12/CXCR4 axisStem cellsTreatment of endometriosisSham control miceEndometrial stem cellsHematopoietic stem cell markersStem cell biomarkersStem cell markersSpontaneous endometriosisRetrograde menstruationControl miceExperimental endometriosisRecipient miceCXCR4 axisLung tissueEndometriosisPeritoneal cavityDsRed miceBlood of animals
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell MovementChemokine CXCL12EndometriosisEndometriumFemaleHumansMesenchymal Stem CellsMiceReceptors, CXCR4ConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSC
2015
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Seminars In Reproductive Medicine 2015, 33: 333-340. PMID: 26375413, PMCID: PMC4986990, DOI: 10.1055/s-0035-1564609.Peer-Reviewed Original ResearchMeSH KeywordsCell MovementChemotaxisEndometriosisEndometriumFemaleHumansMesenchymal Stem CellsMolecular Targeted TherapyRegenerationStem CellsConceptsStem cellsStem cell populationProgenitor stem cellsStem cell traffickingCyclic regenerationPool of cellsCell mobilityBone marrow-derived stem cellsMarrow-derived stem cellsDynamic organRecent characterizationUnrestrained growthCell populationsCell traffickingEctopic sitesCellsRapid regenerationHuman endometriumRegenerationPathologic roleGrowthEndometriosis interferesPathophysiology of endometriosisDevelopment of endometriosisTraffickingThe Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1
Mutlu L, Hufnagel D, Taylor HS. The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1. Biology Of Reproduction 2015, 92: 138, 1-11. PMID: 25904012, PMCID: PMC4652610, DOI: 10.1095/biolreprod.114.126771.Peer-Reviewed Original ResearchMeSH KeywordsEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsRegenerative MedicineWound HealingConceptsMesenchymal stem cellsStem cellsEmbryonic stem cellsAdult stem cellsPluripotent stem cellsPossibility of regeneratingRegenerative medicineTissue regenerationMature cell typesEndometrial stem cellsCell therapyDifferentiation capacityHematopoietic stem cellsCell typesNew frontierNovel sourceCurrent understandingCellsTherapeutic potential
2012
Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium
Du H, Naqvi H, Taylor HS. Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium. Stem Cells And Development 2012, 21: 3324-3331. PMID: 22897736, PMCID: PMC3516416, DOI: 10.1089/scd.2011.0193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell MovementCell ProliferationEndometriumEstrous CycleFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLRegenerationReperfusion InjuryStem CellsUterusConceptsGranulocyte-colony stimulating factorSex steroidsMesenchymal stem cellsUterine repairUterine injuryBone marrowEstrous cycleIschemia/reperfusion injuryStem cellsBM-derived cellsG-CSF treatmentBM transplantsReperfusion injuryBM engraftmentIschemic injuryStem cell recruitmentMenstrual cycleMSC engraftmentCell recruitmentEndometriumInhibits migrationInjuryHematopoietic stem cellsStimulating factorUterus
2010
Cigarette smoke inhibits recruitment of bone-marrow-derived stem cells to the uterus
Zhou Y, Gan Y, Taylor HS. Cigarette smoke inhibits recruitment of bone-marrow-derived stem cells to the uterus. Reproductive Toxicology 2010, 31: 123-127. PMID: 20955787, PMCID: PMC3207965, DOI: 10.1016/j.reprotox.2010.10.007.Peer-Reviewed Original ResearchConceptsCigarette smoke extractStem cell recruitmentBone marrowCell recruitmentCigarette smokingLong-term organ damageHuman mesenchymal stem cellsStem cellsCigarette smoke exposureEndometrial epithelial cellsDecidualization markers prolactinBone marrow cellsMesenchymal stem cell recruitmentSmoking inhibitsOrgan damageSmoke exposureDecreased incidenceEndometrial cellsFemale infertilitySmoke extractUnfiltered cigarettesFemale C57BL/6JMouse modelCigarette smokeUterine sections
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