2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2019
Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction
Wu Y, Yang C, Meng F, Que F, Xiao W, Rao H, Wan Y, Taylor HS, Lu L. Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction. Reproductive Sciences 2019, 26: 386-393. PMID: 29724155, DOI: 10.1177/1933719118773421.Peer-Reviewed Original ResearchConceptsNerve growth factorErectile dysfunctionTotal testosteroneFree testosteroneDiabetes-induced erectile dysfunctionNGF treatmentGrowth factorHyperglycemia-induced downregulationErectile Function scoreIIEF-5 scoreSerum total testosteroneType 2 diabetesMouse Leydig cellsSteroidogenic acute regulatory proteinDiabetic malesSensorimotor polyneuropathySerum testosteroneFunction scoresAcute regulatory proteinInternational IndexClinical studiesED outcomesCytochrome P450 11A1Testosterone biosynthesisLeydig cells
2017
Cigarette Smoking Affects Uterine Receptivity Markers
Ersoy G, Zhou Y, Inan H, Taner CE, Cosar E, Taylor HS. Cigarette Smoking Affects Uterine Receptivity Markers. Reproductive Sciences 2017, 24: 989-995. PMID: 28285568, DOI: 10.1177/1933719117697129.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineCigarette smoking extractReceptivity markersImmunohistochemical analysisEndometrial stromal cell linePrimary human endometrial stromal cellsHuman endometrial stromal cellsFGF2 protein expressionUterine receptivity markersFGF2 expressionCigarette smoke exposureImpact of smokingEffect of smokingImpaired endometrial receptivityReal-time reverse transcription-polymerase chain reactionEndometrial stromal cellsC motif chemokine ligand 12Human endometrial samplesExpression of cytokinesReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionChemokine ligand 12FGF2 mRNA expressionMouse uterine tissueEndometrial health
2016
Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis
Cho S, Mutlu L, Zhou Y, Taylor HS. Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis. Fertility And Sterility 2016, 106: 673-680. PMID: 27320036, PMCID: PMC5831184, DOI: 10.1016/j.fertnstert.2016.05.020.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsLet-7f mimicIshikawa cellsL treatment groupEndometrial cellsAromatase expressionTreatment groupsEndometrial stromal cellsAromatase inhibitor treatmentPathogenesis of endometriosisLet-7f expressionSignificant differencesDose-dependent mannerLetrozole treatmentModulation of microRNAsAromatase inhibitorsLaparoscopic surgeryMAIN OUTCOMEAI treatmentEndometriosisLetrozole concentrationsTherapeutic levelsInhibitor treatmentControl groupTherapeutic potential
2011
Hormonal Regulation of Galectin 3 in Trophoblasts and Its Effects on Endometrium
Yang H, Taylor HS, Lei C, Cheng C, Zhang W. Hormonal Regulation of Galectin 3 in Trophoblasts and Its Effects on Endometrium. Reproductive Sciences 2011, 18: 1118-1127. PMID: 21555510, DOI: 10.1177/1933719111407212.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinGal-3RL95-2 cellsEmbryo implantationEndometrial cellsBeWo cellsGalectin-3Endometrial cell proliferationCell proliferationEndometrial epithelial cellsHormonal regulationExogenous Gal-3Chorionic gonadotropinTrophoblastic cellsVivo modelEndometriumExtracellular effectsIntegrin β3Apoptotic rateProapoptotic effectsEpithelial cellsImplantationIntegrin β1TrophoblastCellsA Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells
Daftary GS, Tetrault AM, Jorgensen EM, Sarno J, Taylor HS. A Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells. Endocrinology 2011, 25: 1539-1549. PMID: 21757506, PMCID: PMC3165913, DOI: 10.1210/me.2011-0001.Peer-Reviewed Original ResearchConceptsEmpty spiracles homeobox 2Novel roleNuclear localization signal sequenceHoxA10 target geneEMX2 expressionDrosophila empty spiraclesCorepressor complexImplantation biologyTranscriptional regulationTranscriptional corepressorTranscriptional complexChromatin immunoprecipitationHuman orthologEndometrial expressionImplantation rateSignal sequenceTranscription factorsEndometrial cellsEmpty spiraclesEmbryo receptivityIshikawa cellsNovel functionTarget genesHomeobox A10Embryo implantation
2010
Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. AJP Endocrinology And Metabolism 2010, 300: e86-e93. PMID: 20959529, PMCID: PMC3023205, DOI: 10.1152/ajpendo.00439.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA, AntisenseEmbryo ImplantationEmbryo, MammalianEmbryonic DevelopmentEndometriumFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansImmune ToleranceMiceOrgan SpecificityRandom AllocationReceptor, Serotonin, 5-HT1DReceptors, SerotoninRNA, MessengerSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsSignal TransductionT-LymphocytesTryptophan OxygenaseUterusConceptsTDO expressionSerotonin productionEndometrial stromaTDO mRNASerotonin receptor subtypesHOXA10 antisenseImmune toleranceImpaired embryo developmentEndometrial glandsSerotonin levelsMurine uterusReceptor subtypesT cellsSerotonin receptorsTryptophan catabolismEmbryo developmentEmbryo implantationTryptophan metabolismBiosynthesis of serotoninTryptophan availabilityHOXA10 expressionEmbryo qualitySerotoninHOXA10Regulation of tryptophanHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10EpitheliumEndothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells
Penna IA, Du H, Kallen AN, Taylor HS. Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells. Reproductive Sciences 2010, 17: 471-476. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineEndometrial stromal cellsEndometrial stromal cell lineFirst trimester decidual cellsStromal cellsHuman endometrial stromal cellsEndometrial epithelial cell lineHuman endometrial epithelial cell lineFirst trimester deciduaVascular smooth muscle cellsReverse transcriptase-polymerase chain reactionQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionSmooth muscle cellsCell linesStromal cell growthG protein-coupled receptorsReproductive-age individualsEndometrial biopsyProtein-coupled receptorsEndometrial receptivityNormal endometriumDecidual samplesElective terminationEpithelial cell line3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells
Du H, Vitiello D, Sarno JL, Taylor HS. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction 2010, 139: 237-245. PMID: 19778996, PMCID: PMC3107855, DOI: 10.1530/rep-08-0376.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineCells, CulturedEndometriumEpithelial CellsFemaleGene Expression Regulation, EnzymologicHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryMenstrual CycleMiceOligonucleotide Array Sequence AnalysisPhosphoglycerate DehydrogenasePregnancyRNA, MessengerRNA, Small InterferingStromal CellsTransfectionConceptsSerine biosynthesisRegulatory relationshipsHOXA10 regulationProtein synthesisPHGDH expressionReal-time PCR resultsStromal cellsCellular differentiationTarget genesHuman endometrial cellsPHGDHMRNA expressionHuman endometrial stromal cellsDe novoWestern blot resultsDehydrogenase expressionBiosynthesisHOXA10Epithelial cellsHOXA10 siRNARegulationExpressionEndometrial stromal cellsHOXA10 expressionBlot results
2008
Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells
Penna I, Du H, Ferriani R, Taylor HS. Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Human Reproduction 2008, 14: 613-618. PMID: 18829447, PMCID: PMC2734161, DOI: 10.1093/molehr/gan055.Peer-Reviewed Original ResearchConceptsEndometrial cellsGlandular cellsDevelopment of endometriosisHuman endometrial cellsExpression of HOXA10Real-time RT-PCRQuantitative real-time RT-PCRHOXA10 siRNAEndometrial biopsyEpithelial cell lineDecidual samplesEutopic endometriumMenstrual cyclePregnancy terminationEndometriosisFertile controlsHOXA10 expressionDecreased expressionRT-PCRProtein expressionRespective controlsHOXA10BiopsyCell linesAberrant regulation
2005
Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells.
Du H, Daftary GS, Lalwani SI, Taylor HS. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Endocrinology 2005, 19: 2222-33. PMID: 15905361, DOI: 10.1210/me.2004-0336.Peer-Reviewed Original ResearchMeSH KeywordsBase PairingCalcitriolCell LineDNA-Binding ProteinsEndometriumFemaleGene Expression RegulationGenes, ReporterHomeobox A10 ProteinsHomeodomain ProteinsHumansLuciferasesMolecular Sequence DataMyeloid CellsPromoter Regions, GeneticReceptors, CalcitriolRNA, MessengerStromal CellsTranscription, GeneticU937 CellsUp-RegulationVitamin D Response ElementConceptsHuman endometrial stromal cell lineVitamin D response elementVitamin D receptorEndometrial stromal cellsHuman endometrial stromal cellsPutative vitamin D response elementsStromal cellsVitamin DPrimary endometrial stromal cellsEndometrial stromal cell linePrimary human endometrial stromal cellsDirect regulationMyeloid leukemic cell differentiationUpstream regulatory sequencesUterine stromal cellsReporter gene expressionCell linesPrimary stromal cellsRegulation of HOXA10Stromal cell lineD response elementHuman myelomonocytic cellsLuciferase reporter constructsLeukemic cell differentiationHuman myelomonocytic cell line
2003
A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line
Sakkas D, Lu C, Zulfikaroglu E, Neuber E, Taylor HS. A soluble molecule secreted by human blastocysts modulates regulation of HOXA10 expression in an epithelial endometrial cell line. Fertility And Sterility 2003, 80: 1169-1174. PMID: 14607569, DOI: 10.1016/s0015-0282(03)02163-0.Peer-Reviewed Original ResearchMeSH KeywordsBiological FactorsBlastocystCell LineChorionic GonadotropinCulture Media, ConditionedEmbryonic and Fetal DevelopmentEndometriumEpithelial CellsFemaleFertilization in VitroHomeobox A10 ProteinsHomeodomain ProteinsHumansReverse Transcriptase Polymerase Chain ReactionSolubilitySperm Injections, IntracytoplasmicConceptsEndometrial epithelial cell lineIntracytoplasmic sperm injectionHOXA10 expressionHOXA10 gene expressionEndometrial receptivityEpithelial cell lineIshikawa cellsCell linesSemiquantitative reverse transcriptase-polymerase chain reactionReverse transcriptase-polymerase chain reactionSoluble moleculesTranscriptase-polymerase chain reactionHigh-quality embryosEndometrial cell lineHuman embryosBlastocyst stageBlastocyst-conditioned mediaCell-free mediumFertilization cyclesBlastocyst appositionPolymerase chain reactionEndometrial cellsMAIN OUTCOMEQuality embryosSperm injectionHOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1
Akbas GE, Taylor HS. HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1. Biology Of Reproduction 2003, 70: 39-45. PMID: 12954737, DOI: 10.1095/biolreprod.102.014969.Peer-Reviewed Original ResearchConceptsEndometrial developmentExpression of HOXC10Secretory phasePrimary endometrial stromal cellsSemiquantitative reverse transcription-polymerase chain reactionEndometrial stromal cellsReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionEndometrial proliferationEndometrial receptivityEndometrial differentiationMenstrual cycleHuman endometriumIshikawa cellsSex steroidsDecreased expressionStromal cellsChain reactionEndometriumHOXA genesHOXA10HOXD10Distinct expression patternsSitu hybridizationHOXC10Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome
Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 238-243. PMID: 12519859, DOI: 10.1210/jc.2002-021072.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeHOXA10 expressionEndometrium of patientsHOXA-10 expressionUterine HOXA10 expressionPregnancy loss rateReproductive-age womenAdverse reproductive outcomesExpression of HOXA10Ovarian androgensOvulatory disordersEndometrial biopsyEndometrial receptivityUterine dysfunctionAndrogen productionPregnancy rateReproductive outcomesTestosterone effectsHOXA10 mRNATestosteroneWomenEndometriumSyndromeHOXA10
2000
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system
Block K, Kardana A, Igarashi P, Taylor H. In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system. The FASEB Journal 2000, 14: 1101-1108. PMID: 10834931, DOI: 10.1096/fasebj.14.9.1101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell LineCycloheximideDiethylstilbestrolEstradiolFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGenitalia, FemaleHomeodomain ProteinsHumansIn Situ HybridizationLitter SizeMaleMiceMullerian DuctsOvaryPregnancyPrenatal Exposure Delayed EffectsRNA, MessengerTeratogensUterusVaginaConceptsHox gene expressionHox genesGene expressionExpression patternsPosterior Hox genesAnterior Hox genesReproductive tractAnterior transformationAcid regulationMolecular mechanismsReproductive tract developmentGenesHOXA10 gene expressionTract developmentExpressionCell culturesMullerian systemPregnant womenAnatomic abnormalitiesFemale offspringDrug usePosterior shiftPotential markerLater stagesMorphogens
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