2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndometriumFemaleHumansMesenchymal Stem CellsPregnancyReproductionStem Cell TransplantationStem CellsConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2018
Uterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndometriumFemaleHumansLeiomyomaMiceModels, AnimalMyometriumStem Cell TransplantationStem CellsTranslational Research, BiomedicalUterine DiseasesConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceTherapeutic strategies involving uterine stem cells in reproductive medicine
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine. Current Opinion In Obstetrics & Gynecology 2018, 30: 209-216. PMID: 29652725, DOI: 10.1097/gco.0000000000000457.Peer-Reviewed Original ResearchMeSH KeywordsEndometriumFemaleHumansInfertility, FemaleRegenerationRegenerative MedicineReproductive MedicineStem Cell TransplantationStem CellsUterine DiseasesUterusConceptsStem cell mobilizationMultipotent stem cellsEndometrial defectAsherman's syndromeStem cellsStem cell biologyEndometrial receptivity defectsLow estrogen levelsBone marrow-derived multipotent stem cellsInjury-induced expressionUterine stem cellsEndometriosis therapyProgenitor stem cellsEndometrial diseaseEstrogen levelsNormal endometriumOverwhelming injuryStem cell recruitmentMenstrual cycleEndometrial cellsStem cell traffickingReservoir of cellsCell recruitmentChemokine CXCL12Therapeutic strategies
2014
Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease
Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Redmond D, Taylor HS. Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease. Journal Of Cellular And Molecular Medicine 2014, 19: 249-256. PMID: 25283241, PMCID: PMC4288367, DOI: 10.1111/jcmm.12433.Peer-Reviewed Original ResearchConceptsEndometrium-derived stem cellsParkinson's diseaseTyrosine hydroxylaseStem cellsDopamine metabolite concentrationsStem cell transplantationTH-positive cellsNeuron-like morphologyTransplanted sideNeuronal lossCell transplantationDopaminergic neuronsSubstantia nigraPrimate modelCell replacement therapyMonkey modelTherapeutic benefitAlternative cell sourcePositive cellsCellular therapyNeurodegenerative diseasesDiseaseTherapyEase of collectionMetabolite concentrationsBone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsFemaleGynatresiaInfertilityMaleMiceMice, Inbred C57BLStem Cell TransplantationConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndrome
2011
Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model
Wolff EF, Gao X, Yao KV, Andrews ZB, Du H, Elsworth JD, Taylor HS. Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model. Journal Of Cellular And Molecular Medicine 2011, 15: 747-755. PMID: 20406327, PMCID: PMC2998585, DOI: 10.1111/j.1582-4934.2010.01068.x.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopaminergic neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDopamine metabolite concentrationsPD mouse modelStem cell transplantationDisease modelsSite of lesionParkinson's disease modelPyramidal cell bodiesPatch-clamp recordingsMesenchymal stem-like cellsAllogenic stem cellsStem cellsStem-like cellsCell transplantationStriatal dopamineNeural markers nestinCentral neuronsDopaminergic cellsDendritic projectionsDopamine synthesisDopamine productionMouse model
2009
Stem Cells and Female Reproduction
Du H, Taylor HS. Stem Cells and Female Reproduction. Reproductive Sciences 2009, 16: 126-139. PMID: 19208782, PMCID: PMC3129037, DOI: 10.1177/1933719108329956.Peer-Reviewed Original ResearchConceptsStem cellsStem cell biologyEndometrial-derived stem cellsNon-reproductive tissuesDerived stem cellsReproductive biologyHematopoietic stem cellsCell biologyEtiology of endometriosisFemale reproductionMaternal diseaseEndometrial regenerationUterine disordersBone marrowRecent findingsBiologyMature oocytesReproductive diseasesCellsOocytesDiseaseTreatmentPotential implicationsReproductionEndometriosis
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