2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell LineCell ProliferationEndometriosisEndometriumFemaleHomeodomain ProteinsHumansProgestinsRNA, Long NoncodingConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2022
Uterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy
Taylor HS. Uterine HOXA11 antisense long non-coding RNA prevents decidualization: A new pathway-regulating pregnancy. Molecular Therapy 2022, 30: 1357-1358. PMID: 35320748, PMCID: PMC9077366, DOI: 10.1016/j.ymthe.2022.03.007.Peer-Reviewed Original ResearchMeSH KeywordsDeciduaEndometriumFemaleHomeodomain ProteinsHumansPregnancyRNA, Long NoncodingTranscription FactorsUterusConceptsPregnancy
2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsDeciduaEmbryo ImplantationFemaleHomeodomain ProteinsMaleMesenchymal Stem CellsMice, KnockoutPregnancyConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2016
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant doseAberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes
Kulp JL, Mamillapalli R, Taylor HS. Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes. Reproductive Sciences 2016, 23: 455-463. PMID: 26865543, PMCID: PMC5933190, DOI: 10.1177/1933719116630427.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesDNA MethylationEndometriumFemaleGenital Diseases, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansMiddle AgedConceptsHOXA10 geneCommon molecular mechanismDNA methylationTranscription factorsMethylation patternsMolecular mechanismsFemale reproductive tractCpG sitesAberrant methylationMethylationGenesMessenger RNACommon gynecologic disorderExpression of HOXA10Endometrium of uterusEmbryonic signalsCertain disease statesAdult endometriumSubmucosal myomasUterine myomaAsherman's syndromeEndometrial receptivityIntramural myomasUterine septumGynecologic diseaseEndometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2015
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harbor Perspectives In Medicine 2015, 6: a023002. PMID: 26552702, PMCID: PMC4691806, DOI: 10.1101/cshperspect.a023002.Peer-Reviewed Original ResearchConceptsReproductive tract developmentEndometrial developmentTract developmentPolycystic ovarian syndromeFemale reproductive tract developmentFemale reproductive trackOvarian syndromeEndometrial receptivityImplantation rateFemale infertilityGene expressionMüllerian defectsHOXA11 expressionGene mutationsReproductive trackAdult functionDevelopmental abnormalitiesHOXA10AbnormalitiesEndocrine disruptorsDiethylstilbestrolImplantationEssential regulatorExpressionThe role of EMX2 in uterine development
Taylor HS. The role of EMX2 in uterine development. Fertility And Sterility 2015, 103: 633-634. PMID: 25637477, DOI: 10.1016/j.fertnstert.2015.01.009.Peer-Reviewed Original ResearchThe Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
Zanatta A, Pereira RM, da Rocha A, Cogliati B, Baracat EC, Taylor HS, da Motta E, Serafini PC. The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study. Reproductive Sciences 2015, 22: 31-37. PMID: 25217304, PMCID: PMC4527422, DOI: 10.1177/1933719114549846.Peer-Reviewed Original ResearchConceptsProgesterone receptorRectosigmoid endometriosisEstrogen receptor αSecretory phaseReceptor αType of endometriosisExpression of ERExpression of HOXA10Tissue microarray blocksConsecutive patientsOvarian endometriosisOvarian lesionsEndometriotic lesionsDeep endometriosisMenstrual cycleAllred scoreExpression of proteinsHomeobox A10Deep diseaseEndometriosisMicroarray blocksSteroid receptorsPatientsReceptorsHOXA10
2013
Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells
Kulak J, Ferriani RA, Komm BS, Taylor HS. Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells. Reproductive Sciences 2013, 20: 129-137. PMID: 23171676, PMCID: PMC3826278, DOI: 10.1177/1933719112463251.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsLeukemia inhibitory factorProgesterone receptorBazedoxifene acetateEndometrial effectsEndometrial proliferationEstrogen complexEffects of raloxifeneRisk of estrogenVehicle-treated controlsEndometrial cell proliferationEstrogen receptor modulatorsEndometrial gene expressionMessenger RNA expressionDifferential effectsEndometrial safetyEstrogen-responsive genesEndometrial hyperplasiaLIF expressionPR expressionEndometrial cellsReceptor modulatorsMore estrogenIshikawa cells
2012
FKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012, 143: 531-538. PMID: 22279148, DOI: 10.1530/rep-11-0438.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsFKBP4 expressionFKBP5 expressionTreatment of hESCCultured human endometrial stromal cellsIGFBP1 expressionEndometrium of womenProtein levelsEndometrial stromal cellsLate proliferative phaseHOXA10 knockdownHOXA10 regulationImpaired decidualizationFertile womenEutopic endometriumMenstrual cycleSecretory phaseEndometriosisDecidualizationHOXA10 expressionProliferative phaseStromal cellsMRNA expressionFKBP5FKBP4
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometriumA Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells
Daftary GS, Tetrault AM, Jorgensen EM, Sarno J, Taylor HS. A Novel Role for the AAA ATPase Spastin as a HOXA10 Transcriptional Corepressor in Ishikawa Endometrial Cells. Endocrinology 2011, 25: 1539-1549. PMID: 21757506, PMCID: PMC3165913, DOI: 10.1210/me.2011-0001.Peer-Reviewed Original ResearchConceptsEmpty spiracles homeobox 2Novel roleNuclear localization signal sequenceHoxA10 target geneEMX2 expressionDrosophila empty spiraclesCorepressor complexImplantation biologyTranscriptional regulationTranscriptional corepressorTranscriptional complexChromatin immunoprecipitationHuman orthologEndometrial expressionImplantation rateSignal sequenceTranscription factorsEndometrial cellsEmpty spiraclesEmbryo receptivityIshikawa cellsNovel functionTarget genesHomeobox A10Embryo implantationCigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1
Zhou Y, Jorgensen EM, Gan Y, Taylor HS. Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1. Biology Of Reproduction 2011, 84: 1242-1247. PMID: 21325691, PMCID: PMC3099588, DOI: 10.1095/biolreprod.110.087494.Peer-Reviewed Original ResearchConceptsProgesterone receptorCigarette smokeRate of endometriosisEffect of smokingCigarette smoke extractEndometrial stromal cellsExpression of HOXA10Poor health outcomesEndometrial cancerEndometrial pathologyEndometrial diseaseCigarette smokingDecreased incidenceOvarian alterationsDecreased prevalenceEndometrial tumorsEndometrial differentiationEndometrial cellsHuman endometriumSmoke extractProtective effectHomeobox A10Health outcomesHomeobox A10 expressionSmokingMaternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming
Martin JR, Lieber SB, McGrath J, Shanabrough M, Horvath TL, Taylor HS. Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming. Endocrinology 2011, 152: 2060-2066. PMID: 21325042, PMCID: PMC3075930, DOI: 10.1210/en.2010-1485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationFemaleFertilityGene Expression Regulation, DevelopmentalGhrelinHeterozygoteHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryLitter SizeMaleMiceMice, KnockoutProliferating Cell Nuclear AntigenReproductionReverse Transcriptase Polymerase Chain ReactionTranscription FactorsUterusWnt ProteinsConceptsGhrelin deficiencyDevelopmental programmingAbnormal endometrial functionFemale wild-type miceUterus of miceLevels of ghrelinRegulation of appetiteWild-type miceReproductive tract developmentWild-type offspringSubsequent subfertilityEndometrial proliferationUnexposed miceEndometrial functionUtero exposureUterine expressionEmbryo implantationOvarian folliclesCorpora luteaGhrelinReproductive tractTract developmentMiceSignificant alterationsSubfertilityEndometrial polyps affect uterine receptivity
Rackow BW, Jorgensen E, Taylor HS. Endometrial polyps affect uterine receptivity. Fertility And Sterility 2011, 95: 2690-2692. PMID: 21269620, PMCID: PMC3096716, DOI: 10.1016/j.fertnstert.2010.12.034.Peer-Reviewed Original Research
2010
HOXA10 expression is decreased in endometrium of women with adenomyosis
Fischer CP, Kayisili U, Taylor HS. HOXA10 expression is decreased in endometrium of women with adenomyosis. Fertility And Sterility 2010, 95: 1133-1136. PMID: 21067721, PMCID: PMC3053130, DOI: 10.1016/j.fertnstert.2010.09.060.Peer-Reviewed Original ResearchRegulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. AJP Endocrinology And Metabolism 2010, 300: e86-e93. PMID: 20959529, PMCID: PMC3023205, DOI: 10.1152/ajpendo.00439.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA, AntisenseEmbryo ImplantationEmbryo, MammalianEmbryonic DevelopmentEndometriumFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansImmune ToleranceMiceOrgan SpecificityRandom AllocationReceptor, Serotonin, 5-HT1DReceptors, SerotoninRNA, MessengerSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsSignal TransductionT-LymphocytesTryptophan OxygenaseUterusConceptsTDO expressionSerotonin productionEndometrial stromaTDO mRNASerotonin receptor subtypesHOXA10 antisenseImmune toleranceImpaired embryo developmentEndometrial glandsSerotonin levelsMurine uterusReceptor subtypesT cellsSerotonin receptorsTryptophan catabolismEmbryo developmentEmbryo implantationTryptophan metabolismBiosynthesis of serotoninTryptophan availabilityHOXA10 expressionEmbryo qualitySerotoninHOXA10Regulation of tryptophanThe role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review
Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, Baracat EC, Serafini PC. The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. Journal Of Assisted Reproduction And Genetics 2010, 27: 701-710. PMID: 20821045, PMCID: PMC2997955, DOI: 10.1007/s10815-010-9471-y.Peer-Reviewed Original ResearchConceptsHOXA10 expressionAspects of endometriosisHomeobox A10 (HOXA10) geneWindow of implantationEtiology of endometriosisRetrograde menstruation theoryMüllerian tractSurgical treatmentRelated infertilityEndometrial expressionEndometriotic fociLaboratory findingsEmbryo implantationEndometriosisInfertilityHOXA10 geneMethodsThis reviewEtiologyHOXA10DiseasePeak of expressionMolecular mechanismsRecent studiesImplantationHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10Epithelium
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