2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2022
Therapeutic role of uterine-derived stem cells in acute kidney injury
Mamillapalli R, Cho S, Mutlu L, Taylor HS. Therapeutic role of uterine-derived stem cells in acute kidney injury. Stem Cell Research & Therapy 2022, 13: 107. PMID: 35279204, PMCID: PMC8917641, DOI: 10.1186/s13287-022-02789-0.Peer-Reviewed Original ResearchConceptsSerum creatinine levelsAKI miceIschemic AKIKidney functionUterine stem cellsKidney injuryCreatinine levelsPositive cellsBilateral renal ischemia-reperfusion injurySurvival rateLower serum creatinine levelsRenal ischemia-reperfusion injuryHigher survival rateBackgroundAcute kidney injuryPrevalence of AKIStem cellsAcute kidney injuryVascular regenerationIschemia-reperfusion injuryKaplan-Meier methodDefinitive treatment optionPromising new therapyExpression of CXCL12CD31-positive cellsUnpaired t-test
2021
Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation
Mamillapalli R, Mutlu L, Taylor HS. Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation. Reproductive Sciences 2021, 29: 2382-2390. PMID: 34515983, DOI: 10.1007/s43032-021-00738-5.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsRecipient miceBone marrow-derived cellsProgenitor cellsBone marrow transplantMarrow-derived cellsMarrow-derived stem cellsSpecific uterine cell typesBone marrow-derived progenitorsMarrow-derived progenitorsUterine cell typesUpregulation of markersCell surface markersStem cellsSpecific stem cell markersStem cell markersCell typesUterine repairMarrow transplantStem cell componentUterine tissueMurine modelMaintenance of fertilityDifferentiation of BMSCsCell markersBone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus
Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.Peer-Reviewed Original ResearchConceptsPostpartum uterusEndometrial stem/progenitor cellsBone marrow-derived progenitor cellsMarrow-derived progenitor cellsF4/80 macrophage markerUterine tissue regenerationProgenitor cellsC57BL/6J female micePostpartum day 1Cytokeratin-positive epithelial cellsBlood vessel endotheliumStem/progenitor cellsPrepregnancy levelsBM transplantsEndometrial regenerationEndometrial cellsFemale miceMacrophage markersPan-leukocytesLuminal epitheliumBone marrowDay 1BMDCsUterine cellsVessel endothelium
2020
Menstruation: science and society
Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim JJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor HS, Wagner GP, Griffith LG. Menstruation: science and society. American Journal Of Obstetrics And Gynecology 2020, 223: 624-664. PMID: 32707266, PMCID: PMC7661839, DOI: 10.1016/j.ajog.2020.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenomyosisAttitudeBiological EvolutionBiomedical ResearchCongresses as TopicDeveloping CountriesEducationEndometriosisEndometriumFemaleGlobal HealthHealth LiteracyHumansLeiomyomaMenstrual Hygiene ProductsMenstruationMenstruation DisturbancesMesenchymal Stem CellsMicrobiotaMicrofluidic Analytical TechniquesNational Institute of Child Health and Human Development (U.S.)RegenerationStem CellsTerminology as TopicTissue EngineeringUnited StatesUterine HemorrhageUterine NeoplasmsUterusWomen's HealthConceptsAbnormal uterine bleedingMenstruation-related disordersUterine bleedingEunice Kennedy Shriver National InstituteHealth concernScarless healing processWomen's health concernsMenstrual healthGynecologic healthUterine preservationMiddle-income countriesProgesterone withdrawalVascular functionClinical challengeHigh-income countriesEndometrial biologyChild healthHealth literacyMost womenHealthy individualsMenstrual physiologyOverall healthReproductive healthDisease BranchMenstruationTherapeutic endometrial regeneration: clinical application of bone marrow‐derived stem cells
Taylor H. Therapeutic endometrial regeneration: clinical application of bone marrow‐derived stem cells. BJOG An International Journal Of Obstetrics & Gynaecology 2020, 127: 561-561. PMID: 31925867, DOI: 10.1111/1471-0528.16088.Peer-Reviewed Original Research
2019
CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMice
2018
Reply: Bone marrow-derived endometrial cells: what you see is what you get
Santamaria X, Mas A, Cervelló I, Taylor HS, Simon C. Reply: Bone marrow-derived endometrial cells: what you see is what you get. Human Reproduction Update 2018, 25: 274-275. PMID: 30601981, DOI: 10.1093/humupd/dmy042.Peer-Reviewed Original ResearchUterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceTherapeutic strategies involving uterine stem cells in reproductive medicine
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine. Current Opinion In Obstetrics & Gynecology 2018, 30: 209-216. PMID: 29652725, DOI: 10.1097/gco.0000000000000457.Peer-Reviewed Original ResearchConceptsStem cell mobilizationMultipotent stem cellsEndometrial defectAsherman's syndromeStem cellsStem cell biologyEndometrial receptivity defectsLow estrogen levelsBone marrow-derived multipotent stem cellsInjury-induced expressionUterine stem cellsEndometriosis therapyProgenitor stem cellsEndometrial diseaseEstrogen levelsNormal endometriumOverwhelming injuryStem cell recruitmentMenstrual cycleEndometrial cellsStem cell traffickingReservoir of cellsCell recruitmentChemokine CXCL12Therapeutic strategies
2017
Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Sahin Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS. Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reproductive Sciences 2017, 24: 818-823. PMID: 28256937, DOI: 10.1177/1933719116682879.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMedroxyprogesterone acetateEstrogen deprivationEndometriosis lesionsStem cell recruitmentCell recruitmentLesions of endometriosisGreen fluorescent protein miceWeeks of treatmentBone marrow transplantLong-term treatmentMarrow-derived stem cellsStem cellsProgestin medroxyprogesterone acetateLong-term regressionBone marrow stem cellsStem cell engraftmentMarrow stem cellsProgestin therapyEndometriosis treatmentLesion regressionMedical therapyEndometriotic lesionsMarrow transplantC57BL/6 miceThe Systemic Effects of Endometriosis
Alderman MH, Yoder N, Taylor HS. The Systemic Effects of Endometriosis. Seminars In Reproductive Medicine 2017, 35: 263-270. PMID: 28658710, DOI: 10.1055/s-0037-1603582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic effectsTreatment of patientsMultiple organ systemsMore effective treatmentsPelvic painEndometrial glandsAutoimmune diseasesBroader systemic effectsCardiovascular diseaseEffective treatmentEndometriosisBody weightPsychiatric conditionsOrgan systemsEctopic locationsStem cell migrationDiseaseComorbiditiesCell migrationTreatmentHypothesized mechanismsDysmenorrheaPainPatientsPathophysiologyBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS. Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reproductive Sciences 2017, 24: 526-533. PMID: 27729562, PMCID: PMC5933203, DOI: 10.1177/1933719116672587.Peer-Reviewed Original ResearchConceptsEutopic endometriumEndometriotic lesionsChemotactic activityCXCR4 messenger RNAProtein expressionTreatment of endometriosisCXCR4 protein expressionStem cellsExpression of CXCL12CXCL12/CXCR4Transwell chamber migrationCXCL12 protein expressionEnzyme-linked immunosorbentBone marrow stem cellsBone marrow cellsMouse bone marrow stem cellsMarrow stem cellsEndometrial tissueControl endometriumGynecological disordersEndometriosisEndometriumChamber migrationCondition mediumCXCL12
2015
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Seminars In Reproductive Medicine 2015, 33: 333-340. PMID: 26375413, PMCID: PMC4986990, DOI: 10.1055/s-0035-1564609.Peer-Reviewed Original ResearchConceptsStem cellsStem cell populationProgenitor stem cellsStem cell traffickingCyclic regenerationPool of cellsCell mobilityBone marrow-derived stem cellsMarrow-derived stem cellsDynamic organRecent characterizationUnrestrained growthCell populationsCell traffickingEctopic sitesCellsRapid regenerationHuman endometriumRegenerationPathologic roleGrowthEndometriosis interferesPathophysiology of endometriosisDevelopment of endometriosisTraffickingChemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Research 2015, 15: 14-22. PMID: 25957946, PMCID: PMC5001152, DOI: 10.1016/j.scr.2015.04.004.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsBone marrow cellsEndometrial stromal cellsCXCR4 expressionEndometrial cellsBM cellsCXCL12/CXCR4 expressionStromal cellsBone marrow-derived stem cellsMarrow-derived stem cellsHuman endometrial cellsStem cellsEndometrial disordersCXCL12 receptorCXCR4 antagonistCXCL12 expressionChemokine CXCL12Uterine endometriumCells engraftBone marrowEndometriumMarrow cellsStem cell migrationCXCR4CXCL12
2014
Identification of Putative Fallopian Tube Stem Cells
Snegovskikh V, Mutlu L, Massasa E, Taylor HS. Identification of Putative Fallopian Tube Stem Cells. Reproductive Sciences 2014, 21: 1460-1464. PMID: 25305130, PMCID: PMC4231131, DOI: 10.1177/1933719114553448.Peer-Reviewed Original ResearchConceptsLabel-retaining cellsStem cellsStem/progenitor cell populationsStem cell nicheProgenitor cell populationsDAPI-stained nucleiStem cell reservePutative stem cellsCell nicheMultiple tissuesProgenitor cellsConfocal microscopyCell populationsImmunofluorescence studiesReproductive tractSection tissueCellsTissue regenerationOviductCell reserveTissueRegenerationNichePopulationNucleusEndometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease
Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Redmond D, Taylor HS. Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease. Journal Of Cellular And Molecular Medicine 2014, 19: 249-256. PMID: 25283241, PMCID: PMC4288367, DOI: 10.1111/jcmm.12433.Peer-Reviewed Original ResearchConceptsEndometrium-derived stem cellsParkinson's diseaseTyrosine hydroxylaseStem cellsDopamine metabolite concentrationsStem cell transplantationTH-positive cellsNeuron-like morphologyTransplanted sideNeuronal lossCell transplantationDopaminergic neuronsSubstantia nigraPrimate modelCell replacement therapyMonkey modelTherapeutic benefitAlternative cell sourcePositive cellsCellular therapyNeurodegenerative diseasesDiseaseTherapyEase of collectionMetabolite concentrationsEndometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 2014, 155: 1489-1497. PMID: 24484171, PMCID: PMC3959601, DOI: 10.1210/en.2013-1977.Peer-Reviewed Original ResearchConceptsBZA/CEConjugated estrogensEndometriosis lesionsStem cell recruitmentCell engraftmentStem cell engraftmentCell recruitmentExperimental endometriosisEutopic endometriumUterine endometriumBone marrowSelective estrogen receptor modulator bazedoxifeneStem cellsMesenchymal stem cell engraftmentLesions of endometriosisMale bone marrowUteri of animalsBazedoxifene treatmentCell nuclear antigenEndometriosis interferesOvarian stimulationVehicle treatmentEndometrial functionNormal endometriumOvarian weight
2013
Stem cells and the reproductive system: Historical perspective and future directions
Duke CM, Taylor HS. Stem cells and the reproductive system: Historical perspective and future directions. Maturitas 2013, 76: 284-289. PMID: 24144960, DOI: 10.1016/j.maturitas.2013.08.012.Peer-Reviewed Original ResearchConceptsEndometrial-derived stem cellsStem cellsNumber of oocytesBone marrow stem cellsFuture therapeutic benefitMarrow stem cellsEndometrial regenerationParenchymal regenerationEndometrial tissueFertility preservationUterine disordersDerived stem cellsFetal stem cellsHuman ovaryMaternal circulationParkinson's diseaseTherapeutic benefitNovel treatmentsMultipotent stem cellsFetal cellsReproductive diseasesDiseaseDisease statesMature oocytesReproductive system
2012
Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium
Du H, Naqvi H, Taylor HS. Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium. Stem Cells And Development 2012, 21: 3324-3331. PMID: 22897736, PMCID: PMC3516416, DOI: 10.1089/scd.2011.0193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell MovementCell ProliferationEndometriumEstrous CycleFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLRegenerationReperfusion InjuryStem CellsUterusConceptsGranulocyte-colony stimulating factorSex steroidsMesenchymal stem cellsUterine repairUterine injuryBone marrowEstrous cycleIschemia/reperfusion injuryStem cellsBM-derived cellsG-CSF treatmentBM transplantsReperfusion injuryBM engraftmentIschemic injuryStem cell recruitmentMenstrual cycleMSC engraftmentCell recruitmentEndometriumInhibits migrationInjuryHematopoietic stem cellsStimulating factorUterus
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