2025
Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, Schwab A, Edwards D, Taylor H, Wenner M. Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women. AJP Heart And Circulatory Physiology 2025, 328: h327-h332. PMID: 39773019, PMCID: PMC12175985, DOI: 10.1152/ajpheart.00815.2024.Peer-Reviewed Original ResearchConceptsPostmenopausal womenExogenous estradiol administrationEndothelin B receptorEstradiol administrationPremenopausal womenLactated RingeHealthy postmenopausal womenYoung womenLaser Doppler flowmetryEndothelin-BVasodilatory responseTransdermal patchDoppler flowmetryCutaneous microcirculationVasodilationEstradiolAdministrationWomenReceptorsRingerBlockadeFlowmetry
2021
Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression
Kotlyar AM, Mamillapalli R, Flores VA, Taylor HS. Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression. Molecular Human Reproduction 2021, 27: gaab016. PMID: 33693775, PMCID: PMC8454207, DOI: 10.1093/molehr/gaab016.Peer-Reviewed Original ResearchConceptsLesion regressionIshikawa cellsJAK/STATGrowth factor mRNA levelsEffects of tofacitinibTreatment of endometriosisHypoxia-inducible factor-1αVascular endothelial growth factor (VEGF) mRNA levelsFactor mRNA levelsWidespread clinical useWestern blot analysisVehicle treatmentOral gavageGynecologic conditionsC57BL/6 miceEutopic endometriumJanus kinase/signal transducerReproductive ageEndometriosisJAK inhibitorsKinase/signal transducerTofacitinibTherapeutic targetLesion growthClinical use
2011
Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome
Wenner MM, Taylor HS, Stachenfeld NS. Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. The Journal Of Physiology 2011, 589: 4671-4679. PMID: 21825025, PMCID: PMC3213415, DOI: 10.1113/jphysiol.2011.216218.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesEndothelin A Receptor AntagonistsEndothelin B Receptor AntagonistsEndothelin-1Endothelin-2Endothelium, VascularFemaleHumansMicrocirculationMicrovesselsOligopeptidesPeptides, CyclicPiperidinesPolycystic Ovary SyndromeReceptor, Endothelin AReceptor, Endothelin BRegional Blood FlowSkinVasoconstrictionVasodilationYoung AdultConceptsPolycystic ovary syndromeET-B receptorsLocal skin warmingOvary syndromeSkin warmingLower vascular reactivityPeripheral microvascular functionLaser Doppler flowmetrySkin blood flowGroup of womenDose-response curveBlunted responsivenessEndothelin BEndothelin AEndothelial dysfunctionVascular reactivityVasoconstrictive responseVasodilatory responseMicrovascular functionCutaneous microvasculatureIntradermal microdialysisAntagonist infusionEndothelin-1Receptor responsivenessReceptor subtypes
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