2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2023
Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice
Habata S, Mamillapalli R, Ucar A, Taylor H. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem Cells International 2023, 2023: 1598127. PMID: 37545483, PMCID: PMC10403325, DOI: 10.1155/2023/1598127.Peer-Reviewed Original ResearchBone marrowMesenchymal stem cellsBM transplantsEndometriotic lesionsM2 macrophagesBone marrow-derived inflammatory cellsTumor necrosis factor alphaImmune system contributionsDonor mesenchymal stem cellsProportion of M1Infiltration of macrophagesDevelopment of endometriosisNecrosis factor alphaNew therapeutic targetsRecipient bone marrowReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEndometriotic lesion developmentInflammatory markersEndometrial tissueInflammatory cellsRecipient micePolymerase chain reactionInflammatory responseFluorescence-activated cell sorting
2020
Accurate diagnosis of endometriosis using serum microRNAs
Moustafa S, Burn M, Mamillapalli R, Nematian S, Flores V, Taylor HS. Accurate diagnosis of endometriosis using serum microRNAs. American Journal Of Obstetrics And Gynecology 2020, 223: 557.e1-557.e11. PMID: 32165186, DOI: 10.1016/j.ajog.2020.02.050.Peer-Reviewed Original ResearchConceptsStage I/IIAbsence of endometriosisMiR-150-5pSerum microRNAsDisease progressionControl groupMiR-451aStage III/IVExpression levelsMiR-125bReproductive Medicine stagingTimely disease detectionTime of surgeryReceiver-operating characteristic areaPresence of symptomsReceiver-operating characteristic analysisNoninvasive diagnostic testMicroRNA biomarkersAcademic medical centerReal-time polymerase chain reactionControl group subjectsHealth care costsQuantitative real-time polymerase chain reactionYears of discomfortNoninvasive diagnostic method
2019
Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis
Cosar E, Mamillapalli R, Moridi I, Duleba A, Taylor HS. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis. Reproductive Sciences 2019, 26: 1343-1350. PMID: 29587611, PMCID: PMC6949973, DOI: 10.1177/1933719118765971.Peer-Reviewed Original ResearchConceptsEndometriosis groupPrimate modelSerum microRNA BiomarkersReproductive-aged womenSerum miRNA expressionTreatment of endometriosisNoninvasive diagnostic strategyMiR-150-5pNonhuman primate modelEstrogen-dependent diseaseReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionTime polymerase chain reactionEndometriosis treatmentEndometriosis severitySimvastatin treatmentHuman endometriosisEndometriosisAccurate biomarkersHuman patientsMiR-451aControl expression levelsDiagnostic strategiesSpecific biomarkersSerum samples
2017
Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production
Nematian SE, Mamillapalli R, Kadakia TS, Zolbin M, Moustafa S, Taylor HS. Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 64-74. PMID: 29040578, DOI: 10.1210/jc.2017-01199.Peer-Reviewed Original ResearchConceptsSera of patientsMacrophage cytokine productionIL-1βIL-6Cytokine productionIL-8Let-7bIL-1β levelsCytokine protein levelsU937 macrophage cell lineCase-control studyTumor necrosis factorLet-7b inhibitorReal-time polymerase chain reactionEnzyme-linked immunosorbentQuantitative real-time polymerase chain reactionMessenger RNA changesSystemic inflammationAberrant inflammationInflammatory cytokinesProinflammatory cytokinesLevels of microRNAsUniversity HospitalPolymerase chain reactionMacrophage cell line
2016
Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis
Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertility And Sterility 2016, 106: 402-409. PMID: 27179784, DOI: 10.1016/j.fertnstert.2016.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultArea Under CurveCase-Control StudiesConnecticutEndometriosisFemaleGene Expression ProfilingGenetic MarkersGenetic Predisposition to DiseaseHospitals, UniversityHumansLogistic ModelsMicroRNAsOligonucleotide Array Sequence AnalysisPhenotypePredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsROC CurveSeoulConceptsMiR-451aMiR-125bSerum microRNAsCase-control studyMiR-150-5pSingle diagnostic biomarkerReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsMiR-342-3pMiR-145-5pPolymerase chain reactionUniversity HospitalDiagnosed subjectsMAIN OUTCOMEEndometriosisDiagnostic biomarkersMiR-500aDiagnostic markerSerum samplesDiagnostic performanceROC curveQRT-PCRChain reactionWomen
2015
Integrative Analysis Reveals Regulatory Programs in Endometriosis
Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS. Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reproductive Sciences 2015, 22: 1060-1072. PMID: 26134036, PMCID: PMC5933170, DOI: 10.1177/1933719115592709.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationComputational BiologyCore Binding Factor Alpha 2 SubunitDatabases, GeneticEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic MarkersHepatocyte Nuclear Factor 3-betaHumansProtein BindingProtein Interaction MappingProtein Interaction MapsReceptors, AndrogenTranscription Factor AP-2Transcription, GeneticTumor Suppressor Protein p53ConceptsAndrogen receptorFunction of ARReproductive-age womenCommon gynecological diseasePathology of endometriosisEstrogen receptor βEstrogen receptor αReal-time polymerase chain reactionSuch expression changesQuantitative real-time polymerase chain reactionPolymerase chain reactionGynecological diseasesGene expressionGene Expression Omnibus databaseEndometriosisReceptor βReceptor αTranscription factors
2014
HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling
Kallen AN, Haines K, Taylor HS. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. Reproductive Sciences 2014, 21: 892-897. PMID: 24532216, PMCID: PMC4107567, DOI: 10.1177/1933719113519168.Peer-Reviewed Original ResearchDynamic intracellular networkExpression levelsProtein expressionCell linesMammalian cytoskeletonEndometrial epithelial cell lineCytoskeletal remodelingEpithelial cell lineIntracellular networksGene expressionCytoskeletal changesQuantitative real-time polymerase chain reactionRegulate expressionHuman endometrial epithelial cell lineMessenger RNACytokeratin 15Cellular architectureKeratin filamentsEpithelial remodelingExpression decreasesTotal RNAHuman endometrial epithelial cellsHuman endometriumReal-time polymerase chain reactionEpithelial cells
2012
Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions
Petracco RG, Kong A, Grechukhina O, Krikun G, Taylor HS. Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions. Reproductive Sciences 2012, 19: 1138-1145. PMID: 22623515, PMCID: PMC4052207, DOI: 10.1177/1933719112443877.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell ProliferationChemokines, CCEmbryo ImplantationEndometriumFemaleFrizzled ReceptorsGene Expression ProfilingHeat-Shock ProteinsHedgehog ProteinsHumansKiller Cells, NaturalMenstrual CycleMetallothioneinReceptor, Angiotensin, Type 2Receptors, ProgesteroneTransforming Growth Factor beta2ConceptsLate proliferative phaseMid-proliferative phaseEarly proliferative phaseProliferative phaseNatural killer cell functionHigh expressionTime pointsKiller cell functionHigher serum levelsChemokine ligand 18Angiotensin II receptorsModulation of inflammationProliferative phase endometriumReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEstrogen-responsive growthGrowth factor β2Metallothionein 2A.Distinct functional subdivisionsUnique gene expression signatureGene expression signaturesEndometrial growthNK cellsSerum levelsEndometrial development
2009
Diminished vaginal HOXA13 expression in women with pelvic organ prolapse
Connell KA, Guess MK, Tate A, Andikyan V, Bercik R, Taylor HS. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. Menopause The Journal Of The North American Menopause Society 2009, 16: 529-533. PMID: 19423998, PMCID: PMC2704499, DOI: 10.1097/gme.0b013e31818fb0c2.Peer-Reviewed Original ResearchConceptsPelvic organ prolapsePremenopausal controlsPremenopausal womenOrgan prolapseHOXA13 expressionPOP groupExpression of HOXA13Real-time polymerase chain reactionExtracellular matrix metabolismEstrogen therapyPostmenopausal womenYounger patientsLeuprolide groupSmoking cessationLeuprolide acetatePolymerase chain reactionBiopsy specimensPreventive strategiesGenetic predispositionVaginal expressionProlapseMatrix metabolismWeight lossWomenVagina
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