2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical response
2022
Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis
Rosa-E-Silva ACJS, Mamillapalli R, Rosa-E-Silva JC, Ucar A, Schwartz J, Taylor HS. Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis. F&S Science 2022, 4: 65-73. PMID: 36252793, DOI: 10.1016/j.xfss.2022.10.003.Peer-Reviewed Original ResearchConceptsC motif chemokine ligand 12Endometriosis groupPregnancy rateChemokine ligand 12Alpha v beta 3 integrinUterine injectionBeta 3 integrinBMDC recruitmentProgesterone receptorMouse modelBone marrow-derived cell recruitmentHigher cumulative pregnancy rateLigand 12Therapeutic agentsEndometrial receptivity defectsCumulative pregnancy rateEndometrial receptivity markersSham surgery groupBone marrow transplantationLower pregnancy ratesAcademic medical centerPotential therapeutic agentReceptivity markersSurgery groupInduced endometriosis
2020
Estrogen receptor-α immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis
Pluchino N, Mamillapalli R, Wenger JM, Ramyead L, Drakopoulos P, Tille JC, Taylor HS. Estrogen receptor-α immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis. Fertility And Sterility 2020, 113: 1224-1231.e1. PMID: 32416979, DOI: 10.1016/j.fertnstert.2020.01.036.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersConstipationCross-Sectional StudiesDysmenorrheaDyspareuniaEndometriosisEstrogen Receptor alphaFemaleHumansImmunohistochemistryMiddle AgedPain MeasurementPredictive Value of TestsProgestinsRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexTissue Array AnalysisTreatment OutcomeYoung AdultConceptsER-α expressionNumerical rating scaleProgesterone receptorAndrogen receptorDeep dyspareuniaDeep endometriosisImmunoreactive scoreProgestin therapyReceptor expressionTissue microarrayExpression of PRMultivariate logistic regression analysisER-α levelsSteroid receptor expressionTime of surgerySeverity of dysmenorrheaSeverity of symptomsLogistic regression analysisNonmenstrual painPain recurrencePain symptomsSevere dysmenorrheaPain persistencePain severityProgestin treatment
2017
Predictive Biomarkers May allow Precision Therapy of Endometriosis
Hou Z, Mamillapalli R, Taylor HS. Predictive Biomarkers May allow Precision Therapy of Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2017, 9: 279-285. PMID: 35441077, PMCID: PMC9014966, DOI: 10.5301/jeppd.5000311.Peer-Reviewed Original ResearchMedroxyprogesterone acetatePredictive biomarkersProgesterone receptorEstrogen receptorPrecision therapyEutopic endometrial stromal cellsSelective estrogen receptor modulatorsEffect of bazedoxifeneEndometrial stromal cellsEstrogen receptor modulatorsPathogenesis of endometriosisPrimary eutopic endometrial stromal cellsCommon molecular targetsPRA/BPersonalized medicine approachReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisBaseline expression levelsPelvic painEndometrial biopsyEndometriosis therapySevere endometriosisProgestin resistanceEndometriosis patientsPR expression
2015
The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
Zanatta A, Pereira RM, da Rocha A, Cogliati B, Baracat EC, Taylor HS, da Motta E, Serafini PC. The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study. Reproductive Sciences 2015, 22: 31-37. PMID: 25217304, PMCID: PMC4527422, DOI: 10.1177/1933719114549846.Peer-Reviewed Original ResearchConceptsProgesterone receptorRectosigmoid endometriosisEstrogen receptor αSecretory phaseReceptor αType of endometriosisExpression of ERExpression of HOXA10Tissue microarray blocksConsecutive patientsOvarian endometriosisOvarian lesionsEndometriotic lesionsDeep endometriosisMenstrual cycleAllred scoreExpression of proteinsHomeobox A10Deep diseaseEndometriosisMicroarray blocksSteroid receptorsPatientsReceptorsHOXA10
2014
Treatment with Bazedoxifene and Conjugated Estrogens Results in Regression of Endometriosis in a Murine Model1
Naqvi H, Sakr S, Presti T, Krikun G, Komm B, Taylor HS. Treatment with Bazedoxifene and Conjugated Estrogens Results in Regression of Endometriosis in a Murine Model1. Biology Of Reproduction 2014, 90: 121, 1-7. PMID: 24740602, PMCID: PMC4093999, DOI: 10.1095/biolreprod.113.114165.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexBZA/CESelective estrogen receptor modulatorsConjugated estrogensLesion sizeEstrogen receptor mRNA expressionFemale CD-1 miceEndometriotic lesion sizeRegression of endometriosisOvarian cyst formationEctopic endometrial lesionsNovel treatment optionsEstrogen receptor modulatorsCD-1 miceReceptor mRNA expressionAction of estrogenMurine Model1Endometrial proliferationEndometrial lesionsUntreated lesionsExperimental endometriosisProgesterone receptorTreatment optionsEstrogen resultsReceptor modulators
2013
Genetic Polymorphisms Associated with Endometriosis in Pakistani Women
Liaqat I, Jahan N, Lone K, Pakstis A, Taylor H. Genetic Polymorphisms Associated with Endometriosis in Pakistani Women. Journal Of Endometriosis And Pelvic Pain Disorders 2013, 5: 134-143. DOI: 10.5301/je.5000165.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsProgesterone receptorGenetic variationGenomic variantsGenesGenetic variantsNucleotide polymorphismsHeritable predispositionMethods DNA samplesAssociation of endometriosisPakistani womenEstrogen receptor betaPathogenesis of endometriosisDNA samplesEstrogen receptor alphaRisk of endometriosisReceptor alphaFunctional promoter polymorphismPolymorphismEnvironmental factorsReceptor betaDirect sequencingEndometriosis subjectsBackground EndometriosisGenetic polymorphismsTissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells
Kulak J, Ferriani RA, Komm BS, Taylor HS. Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells. Reproductive Sciences 2013, 20: 129-137. PMID: 23171676, PMCID: PMC3826278, DOI: 10.1177/1933719112463251.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsLeukemia inhibitory factorProgesterone receptorBazedoxifene acetateEndometrial effectsEndometrial proliferationEstrogen complexEffects of raloxifeneRisk of estrogenVehicle-treated controlsEndometrial cell proliferationEstrogen receptor modulatorsEndometrial gene expressionMessenger RNA expressionDifferential effectsEndometrial safetyEstrogen-responsive genesEndometrial hyperplasiaLIF expressionPR expressionEndometrial cellsReceptor modulatorsMore estrogenIshikawa cells
2011
Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1
Zhou Y, Jorgensen EM, Gan Y, Taylor HS. Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1. Biology Of Reproduction 2011, 84: 1242-1247. PMID: 21325691, PMCID: PMC3099588, DOI: 10.1095/biolreprod.110.087494.Peer-Reviewed Original ResearchConceptsProgesterone receptorCigarette smokeRate of endometriosisEffect of smokingCigarette smoke extractEndometrial stromal cellsExpression of HOXA10Poor health outcomesEndometrial cancerEndometrial pathologyEndometrial diseaseCigarette smokingDecreased incidenceOvarian alterationsDecreased prevalenceEndometrial tumorsEndometrial differentiationEndometrial cellsHuman endometriumSmoke extractProtective effectHomeobox A10Health outcomesHomeobox A10 expressionSmoking
2010
HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10Epithelium
2008
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
Lee B, Du H, Taylor HS. Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1. Biology Of Reproduction 2008, 80: 79-85. PMID: 18799756, PMCID: PMC2804809, DOI: 10.1095/biolreprod.108.070391.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEndometriosisEndometriumFemaleGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryInsulin-Like Growth Factor Binding Protein 1Integrin beta ChainsKruppel-Like Transcription FactorsMiceReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndometriosis groupEndometrial receptivityEutopic endometriumExperimental endometriosisAltered gene expressionInsulin-like growth factorInduction of endometriosisKruppel-like factor 9Expression of HOXA10Total progesterone receptorEndometrial gene expressionBeta3 mRNA expressionProtein-1 mRNAReal-time RT-PCRQuantitative real-time RT-PCRGene expressionMurine endometriosisNormal endometriumProgesterone receptorMethylation-specific PCREndometriosisEndometriumMRNA expressionEctopic locationsGrowth factor
2006
An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells
Kelly M, Daftary G, Taylor HS. An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal Of Obstetrics And Gynecology 2006, 194: 1100-1107. PMID: 16580301, DOI: 10.1016/j.ajog.2005.12.025.Peer-Reviewed Original ResearchConceptsEndometrial epithelial cellsHOXA10 expressionProgesterone receptorAutoregulatory elementRegulatory regionsEpithelial cellsGene expressionBT-20 cellsSteroid-induced gene expressionReporter gene expressionEndometrial receptivityIshikawa cellsSex steroidsBase pair elementSteroid receptorsAlternative molecular mechanismsStromal cellsHOXA10 proteinReporter constructsExpression increasesMolecular mechanismsReceptorsReporter activityDirect bindingHOXA10
2004
HOXA10 Expression in Endometrial Adenocarcinoma
Lane DB, Rutherford TJ, Taylor HS. HOXA10 Expression in Endometrial Adenocarcinoma. Tumor Biology 2004, 25: 264-269. PMID: 15627890, DOI: 10.1159/000081390.Peer-Reviewed Original ResearchConceptsEndometrial adenocarcinomaExpression of HOXA10Endometrial tissueHOXA10 expressionHOXA10 gene expressionNormal endometriumProgesterone receptorEstrogen receptorStage IEndometrial hyperplasiaNeoplastic endometriumGene expressionAdenocarcinomaAbnormal differentiationEndometriumReceptorsSignificant differencesNorthern blot analysisAdult reproductive tissuesBlot analysisHOXA10Aberrant regulationTissueP53Reproductive tissues
2001
HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1
Cermik D, Karaca M, Taylor H. HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 3387-3392. PMID: 11443215, DOI: 10.1210/jcem.86.7.7675.Peer-Reviewed Original ResearchConceptsHox gene expressionHOXA10 expressionHox genesDifferential tissue-specific regulationHigh serum progesterone levelsGene expressionPrimary myometrial cell culturesSerum progesterone levelsDevelopmental regulatory genesAdult human endometriumDifferential HOX gene expressionSteroid receptor coactivatorTissue-specific regulationTissue-specific responsesMyometrial cell culturesEndometrial developmentProgesterone receptorMenstrual cycleHuman endometriumMulticellular organismsNonpregnant uterusProgesterone levelsSex steroidsMidsecretory phaseMyometrium
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