2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical response
2017
Predictive Biomarkers May allow Precision Therapy of Endometriosis
Hou Z, Mamillapalli R, Taylor HS. Predictive Biomarkers May allow Precision Therapy of Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2017, 9: 279-285. PMID: 35441077, PMCID: PMC9014966, DOI: 10.5301/jeppd.5000311.Peer-Reviewed Original ResearchMedroxyprogesterone acetatePredictive biomarkersProgesterone receptorEstrogen receptorPrecision therapyEutopic endometrial stromal cellsSelective estrogen receptor modulatorsEffect of bazedoxifeneEndometrial stromal cellsEstrogen receptor modulatorsPathogenesis of endometriosisPrimary eutopic endometrial stromal cellsCommon molecular targetsPRA/BPersonalized medicine approachReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisBaseline expression levelsPelvic painEndometrial biopsyEndometriosis therapySevere endometriosisProgestin resistanceEndometriosis patientsPR expression
2013
Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells
Kulak J, Ferriani RA, Komm BS, Taylor HS. Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells. Reproductive Sciences 2013, 20: 129-137. PMID: 23171676, PMCID: PMC3826278, DOI: 10.1177/1933719112463251.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsLeukemia inhibitory factorProgesterone receptorBazedoxifene acetateEndometrial effectsEndometrial proliferationEstrogen complexEffects of raloxifeneRisk of estrogenVehicle-treated controlsEndometrial cell proliferationEstrogen receptor modulatorsEndometrial gene expressionMessenger RNA expressionDifferential effectsEndometrial safetyEstrogen-responsive genesEndometrial hyperplasiaLIF expressionPR expressionEndometrial cellsReceptor modulatorsMore estrogenIshikawa cells
2011
Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate
Aldad TS, Rahmani N, Leranth C, Taylor HS. Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate. Fertility And Sterility 2011, 96: 175-179. PMID: 21536273, PMCID: PMC3215335, DOI: 10.1016/j.fertnstert.2011.04.010.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPR expressionReceptor expressionIshikawa cellsNonhuman primatesEstrogen-like effectsAfrican green monkeysQuantitative polymerase chain reactionEffects of bisphenolEndometrial dysfunctionEstrogen inhibitionPolymerase chain reactionBPA exposureMAIN OUTCOMEWeak estrogenGreen monkeysChain reactionVehicle controlPrevious reportsEndocrine disruptorsResultant decreasePrimatesExposureCellsExpression
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