2025
Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, Schwab A, Edwards D, Taylor H, Wenner M. Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women. AJP Heart And Circulatory Physiology 2025, 328: h327-h332. PMID: 39773019, PMCID: PMC12175985, DOI: 10.1152/ajpheart.00815.2024.Peer-Reviewed Original ResearchConceptsPostmenopausal womenExogenous estradiol administrationEndothelin B receptorEstradiol administrationPremenopausal womenLactated RingeHealthy postmenopausal womenYoung womenLaser Doppler flowmetryEndothelin-BVasodilatory responseTransdermal patchDoppler flowmetryCutaneous microcirculationVasodilationEstradiolAdministrationWomenReceptorsRingerBlockadeFlowmetry
2023
Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016
Beroukhim G, Kayani J, Taylor H, Pal L. Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016. Menopause The Journal Of The North American Menopause Society 2023, 30: 906-912. PMID: 37625087, DOI: 10.1097/gme.0000000000002233.Peer-Reviewed Original ResearchConceptsMenopausal statusBody mass indexSmoking exposureMass indexNational HealthLinear regression analysisTCS levelsTriclosan levelsRetrospective cross-sectional studyMultivariable linear regression analysisReproductive health questionnaireUrinary triclosan levelsDuration of menopauseMultivariate linear regression analysisNutrition Examination SurveyCross-sectional studyYears of ageRegression analysisFemale participantsPostmenopausal statusPostmenopausal womenPremenopausal womenSurgical menopausePremature menopauseUrinary levels
2019
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
Miller VM, Naftolin F, Asthana S, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Gleason CE, Hodis HN, Jayachandran M, Kantarci K, Lobo RA, Manson JE, Pal L, Santoro NF, Taylor HS, Harman SM. The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned? Menopause The Journal Of The North American Menopause Society 2019, 26: 1071-1084. PMID: 31453973, PMCID: PMC6738629, DOI: 10.1097/gme.0000000000001326.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyCarotid artery intima-media thicknessPostmenopausal womenPrevention StudyAncillary studiesO-CEEHealth initiativesArtery intima-media thicknessInitiation of HTPlacebo-controlled trialCoronary artery calciumEffect of menopauseWomen's Health InitiativeIntima-media thicknessProgression of atherosclerosisAge of menopauseBone mineral densitySevere adverse effectsWhite matter hyperintensitiesVariants of genesMenopausal hormonesBreast painArtery calciumUse of HTVenous thrombosis
2018
Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
Cintron D, Lahr BD, Bailey KR, Santoro N, Lloyd R, Manson JE, Neal-Perry G, Pal L, Taylor HS, Wharton W, Naftolin F, Harman SM, Miller VM. Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Menopause The Journal Of The North American Menopause Society 2018, 25: 145-153. PMID: 28832429, PMCID: PMC5771895, DOI: 10.1097/gme.0000000000000971.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyHormone therapyDomains of sleepSleep qualityDomain scoresMenopausal womenPrevention StudySleep domainsGlobal Pittsburgh Sleep Quality Index scoreOral conjugated equine estrogenPittsburgh Sleep Quality Index scorePittsburgh Sleep Quality IndexVasomotor symptom scoresConjugated equine estrogensSleep Quality IndexPoor sleep qualityGlobal sleep qualitySeverity of symptomsGlobal sleep scoreQuality Index scoresMenopausal hormonesVMS severityPostmenopausal womenVasomotor symptomsSpearman correlation coefficient
2017
Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS)
Taylor HS, Tal A, Pal L, Li F, Black DM, Brinton EA, Budoff MJ, Cedars MI, Du W, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Neal-Perry G, Santoro NF, Harman SM. Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS). JAMA Internal Medicine 2017, 177: 1471-1479. PMID: 28846767, PMCID: PMC5710212, DOI: 10.1001/jamainternmed.2017.3877.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultDouble-Blind MethodEstradiolEstrogen Replacement TherapyEstrogensEstrogens, Conjugated (USP)FemaleFollow-Up StudiesGlucuronatesHumansMiddle AgedPostmenopauseProgesteroneProgestinsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRisk FactorsSexual Dysfunction, PhysiologicalTime FactorsWomen's HealthConceptsKronos Early Estrogen Prevention StudyLow sexual functionTransdermal estrogen therapySexual functionAncillary studiesEstrogen therapyPostmenopausal womenPrevention StudyT-E2Female Sexual Function InventoryOral conjugated equine estrogenOverall scoreLower FSFI scoresEarly postmenopausal womenMenopausal hormone therapyPlacebo-controlled trialOral micronized progesteroneConjugated equine estrogensSexual Function InventoryLast menstrual periodEffects of OralQuality of lifeProportion of womenSymptoms of distressMicronized progesteroneLongitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo
Santoro N, Allshouse A, Neal-Perry G, Pal L, Lobo RA, Naftolin F, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Dunn M, Gleason CE, Hodis HN, Isaac B, Magnani M, Manson JE, Miller VM, Taylor HS, Wharton W, Wolff E, Zepeda V, Harman SM. Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo. Menopause The Journal Of The North American Menopause Society 2017, 24: 238-246. PMID: 27779568, PMCID: PMC5323337, DOI: 10.1097/gme.0000000000000756.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultAutonomic Nervous System DiseasesDrug Therapy, CombinationEstradiolEstrogen Replacement TherapyEstrogensEstrogens, Conjugated (USP)FemaleHot FlashesHumansIrritable MoodLongitudinal StudiesMiddle AgedPostmenopauseProgesteroneProgestinsSleep Initiation and Maintenance DisordersTreatment OutcomeVasomotor SystemConceptsOral conjugated estrogensActive treatment armsBody mass indexTreatment armsRace/ethnicityMonths postrandomizationNight sweatsPostmenopausal womenHot flashesMass indexMenopausal symptomsConjugated estrogensEarly postmenopausal womenMenopausal hormone therapyFinal menstrual periodProportion of womenHormone regimensTransdermal estradiolTransdermal estrogenHormone therapyVasomotor symptomsSymptom reliefTreat analysisActive treatmentConventional doses
2016
Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium
Flannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS. Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology 2016, 157: 3699-3708. PMID: 27267714, PMCID: PMC5045514, DOI: 10.1210/en.2016-1233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsBasic Helix-Loop-Helix Transcription FactorsCarcinoma, EndometrioidCase-Control StudiesCells, CulturedEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleFibroblast Growth FactorsGene Expression ProfilingHumansIndolesMiceMiddle AgedSelective Estrogen Receptor ModulatorsConceptsStromal cellsPostmenopausal womenHormone therapyEpithelial proliferationFGF18 expressionAntiproliferative effectsSelective estrogen receptor modulatorsHuman endometrial stromal cellsGrowth factorBZA/CEMenopausal hormone therapyEndometrial stromal cellsBreast cancer riskEstrogen receptor modulatorsCD1 female miceE74-like factor 5Normal proliferative endometriumParacrine growth factorPrimary stromal cellsTyrosine kinase receptor 2Fibroblast growth factorEndometrial hyperplasiaEndometrial proliferationEndometrial cancerEndometrial adenocarcinoma
2014
Differential effects of menopausal therapies on the endometrium
Mirkin S, Archer DF, Taylor HS, Pickar JH, Komm BS. Differential effects of menopausal therapies on the endometrium. Menopause The Journal Of The North American Menopause Society 2014, 21: 899-908. PMID: 24518153, DOI: 10.1097/gme.0000000000000186.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsEstrogen-progestin therapyEndometrial profileEndometrial safetyEndometrial effectsEstrogen therapyMenopausal symptomsEstrogen receptor degradationNew hormone therapiesIndividual selective estrogen receptor modulatorsIrregular uterine bleedingIncidence of hyperplasiaEstrogen receptor modulatorsMenopausal therapyTolerability profileUterine bleedingEndometrial proliferationHormone therapyPostmenopausal womenEndometrial cancerClinical findingsSafety profileAvailable treatmentsReceptor modulatorsThe KEEPS-Cognitive and Affective Study: Baseline Associations between Vascular Risk Factors and Cognition
Wharton W, Gleason CE, Dowling NM, Carlsson CM, Brinton EA, Santoro MN, Neal-Perry G, Taylor H, Naftolin F, Lobo RA, Merriam G, Manson JE, Cedars MI, Miller VM, Black DM, Budoff M, Hodis HN, Harman SM, Asthana S. The KEEPS-Cognitive and Affective Study: Baseline Associations between Vascular Risk Factors and Cognition. Journal Of Alzheimer’s Disease 2014, 40: 331-341. PMID: 24430001, PMCID: PMC4367860, DOI: 10.3233/jad-130245.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultAttentionBlood GlucoseBlood PressureCholesterol, HDLCholesterol, LDLCognition DisordersDouble-Blind MethodEstradiolEstrogensFemaleHormonesHumansLongitudinal StudiesMiddle AgedMood DisordersNeuropsychological TestsPsychiatric Status Rating ScalesRisk FactorsConceptsVascular risk factorsSystolic blood pressureBlood pressureRisk factorsAlzheimer's diseaseCognitive dysfunctionMidlife vascular risk factorsOral conjugated equine estrogenHigher systolic blood pressureConjugated equine estrogensLower blood pressureSerum estradiol levelsHigh blood pressurePostmenopausal womenVascular riskBP levelsEquine estrogensEstradiol levelsMenopausal womenParallel groupClinical trialsHormone levelsCognitive domainsBaseline associationsCognitive declineCurrent and Evolving Approaches to Individualizing Estrogen Receptor-Based Therapy for Menopausal Women
Santen RJ, Kagan R, Altomare CJ, Komm B, Mirkin S, Taylor HS. Current and Evolving Approaches to Individualizing Estrogen Receptor-Based Therapy for Menopausal Women. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: 733-747. PMID: 24423357, DOI: 10.1210/jc.2013-3680.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective ER modulatorsPostmenopausal womenEstrogen deficiencyMenopausal womenAvailable estrogen receptorRelevant English-language articlesHysterectomized postmenopausal womenLarge observational studiesReceptor-based therapiesEnglish-language articlesPossible adverse effectsOptimal therapeutic profileProgestogen useSystemic estrogenHormonal therapyHormone therapyTherapeutic guidelinesMenopausal symptomsEstrogen complexObservational studyDifferent therapiesEstrogen receptorER agonismIndividualized approach
2013
Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance
Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam GR, Wharton W, Naftolin F, Taylor H, Harman SM, Asthana S. Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance. PLOS ONE 2013, 8: e68741. PMID: 23874743, PMCID: PMC3714288, DOI: 10.1371/journal.pone.0068741.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyLow-risk classPostmenopausal womenCV risk factor profileDisease riskApolipoprotein E (APOE) ε4 alleleCV risk classificationCV risk profileHigh-risk womenRisk factor profileCV disease riskVascular disease riskLast menstrual periodConsiderable interindividual variabilityEducation levelHigh-risk classCV diseaseCV riskCardiovascular riskMenopausal womenMenstrual periodPrevention StudyPreclinical diseasePreventive strategiesTreatment decisions
2012
Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS study
Huang G, Wang D, Khan UI, Zeb I, Manson JE, Miller V, Hodis HN, Budoff MJ, Merriam GR, Harman MS, Brinton EA, Cedars MI, Su Y, Lobo RA, Naftolin F, Santoro N, Taylor HS, Wildman RP. Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS study. Cardiovascular Diabetology 2012, 11: 52. PMID: 22587616, PMCID: PMC3461442, DOI: 10.1186/1475-2840-11-52.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAtherosclerosisBiomarkersBlood GlucoseBlood PressureC-Reactive ProteinCarotid Intima-Media ThicknessCoronary DiseaseCross-Sectional StudiesDouble-Blind MethodFemaleHormone Replacement TherapyHumansInsulinLife StyleLipidsMiddle AgedObesityPostmenopauseRadiographyRetinol-Binding Proteins, PlasmaRisk FactorsConceptsRetinol-binding protein 4Carotid artery intima-media thicknessCoronary artery calcificationCardiometabolic risk factorsRBP4 levelsHigher RBP4 levelsRisk factorsPostmenopausal womenCross-sectional analysisSubclinical atherosclerosisKronos Early Estrogen Prevention StudyArtery intima-media thicknessSubclinical coronary atherosclerosisResultsThe mean ageSerum RBP4 levelsProtein 4C-reactive proteinIntima-media thicknessAdditional risk factorsWestern blot analysisArtery calcificationCIMT levelsCoronary atherosclerosisBlood pressureHigh triglyceridesUsing bazedoxifene plus conjugated estrogens for treating postmenopausal women
Taylor HS, Ohleth K. Using bazedoxifene plus conjugated estrogens for treating postmenopausal women. Menopause The Journal Of The North American Menopause Society 2012, 19: 479-485. PMID: 22278343, DOI: 10.1097/gme.0b013e31823dbbca.Peer-Reviewed Original ResearchConceptsBZA/CETissue selective estrogenConjugated estrogensPostmenopausal womenBone massSelective estrogenVulvar-vaginal atrophyPlacebo-controlled studyHot flush frequencyLevel I evidenceAmenorrhea ratesEndometrial hyperplasiaEndometrial stimulationHot flushesClinical outcomesClinical efficacyI evidenceFlush frequencySafety outcomesEstrogenPlaceboBazedoxifeneWomenOverall safetyUnexpected finding
2011
Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS)
Huang G, Wang D, Zeb I, Budoff MJ, Harman SM, Miller V, Brinton EA, Khoudary S, Manson JE, Sowers MR, Hodis HN, Merriam GR, Cedars MI, Taylor HS, Naftolin F, Lobo RA, Santoro N, Wildman RP. Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis 2011, 221: 198-205. PMID: 22209479, PMCID: PMC3288598, DOI: 10.1016/j.atherosclerosis.2011.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdultAge FactorsAsymptomatic DiseasesBiomarkersBody Mass IndexC-Reactive ProteinCoronary Artery DiseaseDouble-Blind MethodEstrogen Replacement TherapyFemaleHumansInsulinLinear ModelsLiverLogistic ModelsMetabolic SyndromeMiddle AgedMultivariate AnalysisOdds RatioPericardiumPostmenopauseProspective StudiesRisk AssessmentRisk FactorsTomography, X-Ray ComputedUnited StatesVascular CalcificationWaist CircumferenceConceptsKronos Early Estrogen Prevention StudyCoronary artery calcificationIntra-hepatic fatCVD risk markersThoracic fatHs-CRPPrevention StudyRisk markersRisk factorsCardiac fatCardiovascular disease risk factorsCardiometabolic risk factorsDisease risk factorsSubclinical cardiovascular diseaseSubclinical atherosclerosis burdenThoracic adipose tissueAtherosclerosis burdenMultivariable adjustmentArtery calcificationCVD riskPostmenopausal womenSubclinical atherosclerosisMenopausal womenHepatic fatAdiposity measures
2010
Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: baseline characteristics of the skin ancillary study of the KEEPS trial
Wolff E, Pal L, Altun T, Madankumar R, Freeman R, Amin H, Harman M, Santoro N, Taylor HS. Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: baseline characteristics of the skin ancillary study of the KEEPS trial. Fertility And Sterility 2010, 95: 658-662.e3. PMID: 20971461, PMCID: PMC3026089, DOI: 10.1016/j.fertnstert.2010.09.025.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyEarly menopausal womenBody mass indexMenopausal womenHormone therapySkin wrinklesEffects of HTLowest wrinkle scoresEarly postmenopausal womenSkin wrinklingUniversity Medical CenterSignificant racial differencesSkin characteristicsRace/ethnic groupsSkin rigidityRace/ethnicityMenopausal participantsBaseline characteristicsPostmenopausal womenMulticenter trialMass indexPrevention StudyAncillary studiesMedical CenterStudy groupEffects of bazedoxifene/conjugated estrogens on metabolic parameters: a randomized, placebo-controlled clinical trial in postmenopausal women
Taylor H, Mirkin S, Chines A. Effects of bazedoxifene/conjugated estrogens on metabolic parameters: a randomized, placebo-controlled clinical trial in postmenopausal women. Fertility And Sterility 2010, 94: s44. DOI: 10.1016/j.fertnstert.2010.07.170.Peer-Reviewed Original Research
2009
Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman
Sasson IE, Taylor HS. Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman. Fertility And Sterility 2009, 92: 1170.e1-1170.e4. PMID: 19591983, PMCID: PMC2742473, DOI: 10.1016/j.fertnstert.2009.05.071.Peer-Reviewed Original ResearchConceptsPostmenopausal womenEstradiol levelsAromatase inhibitorsAbdominal wallAbdominal wall endometriomaPost-menopausal patientsPost-menopausal womenUnusual clinical presentationAcademic medical centerSource of estrogenRecurrent abdominal wallEndometriotic implantsMedical therapyClinical presentationCyst aspirationCase reportSonographic demonstrationAromatase activityMedical CenterMAIN OUTCOMEWomenPatientsEstrogenSerumInhibitorsDiminished vaginal HOXA13 expression in women with pelvic organ prolapse
Connell KA, Guess MK, Tate A, Andikyan V, Bercik R, Taylor HS. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. Menopause The Journal Of The North American Menopause Society 2009, 16: 529-533. PMID: 19423998, PMCID: PMC2704499, DOI: 10.1097/gme.0b013e31818fb0c2.Peer-Reviewed Original ResearchConceptsPelvic organ prolapsePremenopausal controlsPremenopausal womenOrgan prolapseHOXA13 expressionPOP groupExpression of HOXA13Real-time polymerase chain reactionExtracellular matrix metabolismEstrogen therapyPostmenopausal womenYounger patientsLeuprolide groupSmoking cessationLeuprolide acetatePolymerase chain reactionBiopsy specimensPreventive strategiesGenetic predispositionVaginal expressionProlapseMatrix metabolismWeight lossWomenVagina
2008
Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: baseline characteristics of participants enrolled in the skin ancillary study of the keeps trial
Wolff E, Altun T, Madankumar R, Pal L, Santoro N, Taylor H. Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: baseline characteristics of participants enrolled in the skin ancillary study of the keeps trial. Fertility And Sterility 2008, 90: s252. DOI: 10.1016/j.fertnstert.2008.07.1321.Peer-Reviewed Original Research
2004
The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition
Naftolin F, Taylor HS, Karas R, Brinton E, Newman I, Clarkson TB, Mendelsohn M, Lobo RA, Judelson DR, Nachtigall LE, Heward CB, Hecht H, Jaff MR, Harman SM. The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition. Fertility And Sterility 2004, 81: 1498-1501. PMID: 15193467, DOI: 10.1016/j.fertnstert.2004.02.095.Peer-Reviewed Original Research
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