2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cells
2019
Evaluation of miR-135a/b expression in endometriosis lesions
Petracco R, De Oliveira Dias A, Taylor H, Petracco Á, Badalotti M, Da Rosa Michelon J, Marinowic DR, Hentschke M, De Azevedo P, Zanirati G, Machado DC. Evaluation of miR-135a/b expression in endometriosis lesions. Biomedical Reports 2019, 11: 181-187. PMID: 31565224, PMCID: PMC6759580, DOI: 10.3892/br.2019.1237.Peer-Reviewed Original ResearchEndometriosis lesionsEndometrium tissuesSecretory phaseProliferative phaseExpression levelsReverse transcription‑quantitative polymerase chain reaction assaysEctopic endometriosis lesionsTranscription-quantitative polymerase chain reaction assaysPathogenesis of endometriosisEctopic endometrium tissuesEutopic endometrium tissuesPolymerase chain reaction assaysEndometrial functioningEndometrial receptivityMenstrual cycleChain reaction assaysLaparoscopic surgeryPost-transcriptional regulationEmbryo implantationQuantitative polymerase chain reaction assaysShort noncoding RNAsB expressionIncreased expressionExpression of genesLesionsPotential roles of aquaporin 9 in the pathogenesis of endometriosis
Choi YS, Park JH, Yoon JK, Yoon JS, Kim JS, Lee JH, Yun BH, Park JH, Seo SK, Cho S, Lee BS, Taylor HS. Potential roles of aquaporin 9 in the pathogenesis of endometriosis. Molecular Human Reproduction 2019, 25: 373-384. PMID: 31070762, DOI: 10.1093/molehr/gaz025.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsPathogenesis of endometriosisEndometrial stromal cellsPotential therapeutic targetExpression of MMP2P38 MAPK proteinWestern blot analysisControl patientsEndometrial expressionPhosphorylated ERK 1/2Ectopic endometriumEutopic endometriumInflammatory processLaparoscopic surgeryEndometriosisTherapeutic targetBenign conditionsAQP subtypesExpression of AQP9Stromal cellsTumor developmentWestern blottingAQP9 expressionHealing assaysERK 1/2
2018
Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis
Hu Z, Mamillapalli R, Taylor HS. Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis. AJP Endocrinology And Metabolism 2018, 316: e373-e382. PMID: 30576245, PMCID: PMC6459299, DOI: 10.1152/ajpendo.00244.2018.Peer-Reviewed Original ResearchConceptsEndometriotic cellsSteroidogenic factor 1Primary endometriotic cellsReproductive-aged womenAltered expressionSera of patientsPathogenesis of endometriosisCell proliferationFactor 1SF-1Novel therapeutic strategiesSteroidogenic acute regulatory proteinGynecologic diseaseEndometrial tissueEndometriotic lesionsAcute regulatory proteinSF-1 mRNA levelsEndometriosisTherapeutic strategiesEstrogen biosynthesisMRNA levelsRespective controlsWomenEssential transcriptional regulatorSerum
2017
Predictive Biomarkers May allow Precision Therapy of Endometriosis
Hou Z, Mamillapalli R, Taylor HS. Predictive Biomarkers May allow Precision Therapy of Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2017, 9: 279-285. PMID: 35441077, PMCID: PMC9014966, DOI: 10.5301/jeppd.5000311.Peer-Reviewed Original ResearchMedroxyprogesterone acetatePredictive biomarkersProgesterone receptorEstrogen receptorPrecision therapyEutopic endometrial stromal cellsSelective estrogen receptor modulatorsEffect of bazedoxifeneEndometrial stromal cellsEstrogen receptor modulatorsPathogenesis of endometriosisPrimary eutopic endometrial stromal cellsCommon molecular targetsPRA/BPersonalized medicine approachReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisBaseline expression levelsPelvic painEndometrial biopsyEndometriosis therapySevere endometriosisProgestin resistanceEndometriosis patientsPR expression
2016
Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis
Cho S, Mutlu L, Zhou Y, Taylor HS. Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis. Fertility And Sterility 2016, 106: 673-680. PMID: 27320036, PMCID: PMC5831184, DOI: 10.1016/j.fertnstert.2016.05.020.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsLet-7f mimicIshikawa cellsL treatment groupEndometrial cellsAromatase expressionTreatment groupsEndometrial stromal cellsAromatase inhibitor treatmentPathogenesis of endometriosisLet-7f expressionSignificant differencesDose-dependent mannerLetrozole treatmentModulation of microRNAsAromatase inhibitorsLaparoscopic surgeryMAIN OUTCOMEAI treatmentEndometriosisLetrozole concentrationsTherapeutic levelsInhibitor treatmentControl groupTherapeutic potential
2013
Genetic Polymorphisms Associated with Endometriosis in Pakistani Women
Liaqat I, Jahan N, Lone K, Pakstis A, Taylor H. Genetic Polymorphisms Associated with Endometriosis in Pakistani Women. Journal Of Endometriosis And Pelvic Pain Disorders 2013, 5: 134-143. DOI: 10.5301/je.5000165.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsProgesterone receptorGenetic variationGenomic variantsGenesGenetic variantsNucleotide polymorphismsHeritable predispositionMethods DNA samplesAssociation of endometriosisPakistani womenEstrogen receptor betaPathogenesis of endometriosisDNA samplesEstrogen receptor alphaRisk of endometriosisReceptor alphaFunctional promoter polymorphismPolymorphismEnvironmental factorsReceptor betaDirect sequencingEndometriosis subjectsBackground EndometriosisGenetic polymorphismsMedical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Obstetrics And Gynecology 2013, 65: 199-213. PMID: 23598784, PMCID: PMC3718308.Peer-Reviewed Original ResearchConceptsPeritoneal microenvironmentMedical managementDisease pathophysiologyEndometrial progesterone resistanceAppropriate medical managementPathogenesis of endometriosisProgesterone-responsive genesNew therapeutic targetsDisease developmentFemale reproductive tractProgesterone resistanceProinflammatory processesEutopic endometriumRisk factorsProgesterone actionPatients exhibitTherapeutic targetEndometriosisReproductive tractProtein expressionNovel mechanistic frameworkEndometriumInflammationPathophysiologyDisease establishment
2012
Endometrial Stem Cells.
Taylor H. Endometrial Stem Cells. Biology Of Reproduction 2012, 87: 32-32. DOI: 10.1093/biolreprod/87.s1.32.Peer-Reviewed Original ResearchProgenitor stem cellsMesenchymal stem cellsUterine injuryMenstrual cycleMultipotent stem cellsStem cellsAdult progenitor stem cellsPathogenesis of endometriosisEndometrial stem cellsMurine diabetes modelPancreatic beta cellsAsherman's syndromeEndometrial regenerationDopaminergic neuronsDiabetes modelRetrograde fashionMurine modelPeritoneal cavitySex steroidsParkinson's diseaseBeta cellsBone marrowEndometriosisRemarkable regenerative capacityEctopic locations
2011
Stem cells in endometrium and their role in the pathogenesis of endometriosis
Figueira PG, Abrão MS, Krikun G, Taylor H. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Annals Of The New York Academy Of Sciences 2011, 1221: 10-17. PMID: 21401624, PMCID: PMC3076708, DOI: 10.1111/j.1749-6632.2011.05969.x.Peer-Reviewed Original ResearchConceptsProgenitor stem cellsPathogenesis of endometriosisMesenchymal stem cellsMultipotent stem cellsStem cellsAdult progenitor stem cellsEndometrial stem cellsDopaminergic neuronsMenstrual cycleHuman endometriumRetrograde fashionMurine modelPeritoneal cavityParkinson's diseaseEndometriosisBone marrowRemarkable regenerative capacityEndometriumEctopic locationsRegenerative capacityPathogenesisDiseaseNeuronsDynamic tissueCellsHOX Genes and Endometriosis
Kulp J, Cakmak H, Taylor H. HOX Genes and Endometriosis. 2011, 184-189. DOI: 10.1002/9781444398519.ch18.Peer-Reviewed Original Research
2008
Stem Cells and the Pathogenesis of Endometriosis
Sasson IE, Taylor HS. Stem Cells and the Pathogenesis of Endometriosis. Annals Of The New York Academy Of Sciences 2008, 1127: 106-115. PMID: 18443337, PMCID: PMC3107843, DOI: 10.1196/annals.1434.014.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisGynecological disordersEndometrial stem/progenitor cellsChronic pelvic painCommon gynecological disorderEndometrial stem cellsStem/progenitor cellsStem cellsPelvic painEndometrial tissueUterine cavityLikely multifactorialExtensive morbidityMenstrual cycleEndometriosisRole of geneticsImmune systemNarrative reviewPathogenesisProgenitor cellsPotential roleImportant unanswered questionsSuch cellsDisordersCells
2006
HOXA10 expression in ectopic endometrial tissue
Browne H, Taylor H. HOXA10 expression in ectopic endometrial tissue. Fertility And Sterility 2006, 85: 1386-1390. PMID: 16647375, DOI: 10.1016/j.fertnstert.2005.10.072.Peer-Reviewed Original ResearchConceptsEctopic endometrial tissueEndometrial tissueHOXA10 expressionEndometrial developmentEctopic endometriumEutopic endometriumLung parenchymaH-scoreNormal endometrial developmentEutopic endometrial tissuesPathogenesis of endometriosisHOXA10 protein expressionMean H-scoreOvarian endometriomaFertile womenPelvic peritoneumStromal expressionMAIN OUTCOMEEndometriosisGlandular epitheliumEndometriumDiminished expressionProtein expressionHOXA10P resistance
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply