2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDisease
2019
Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain
Taylor HS, Dun EC, Chwalisz K. Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain. Pain Management 2019, 9: 497-515. PMID: 31434540, DOI: 10.2217/pmt-2019-0010.Peer-Reviewed Original ResearchConceptsEndometriosis-associated painPain symptomsEstrogen-dependent chronic inflammatory diseaseSevere endometriosis-associated painCurrent medical treatment optionsNonmenstrual pelvic painPelvic pain symptomsMedical treatment optionsChronic inflammatory diseasePathophysiology of endometriosisRole of estrogenEstrogen suppressionCentral sensitizationPelvic painTreatment optionsClinical evaluationInflammatory diseasesPainClinical developmentHigh dosesLow dosesElagolixUS FDAEndometriosisSymptomsEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesionsMicroRNAs in endometriosis: biological function and emerging biomarker candidates†
Bjorkman S, Taylor HS. MicroRNAs in endometriosis: biological function and emerging biomarker candidates†. Biology Of Reproduction 2019, 101: 1167-1178. PMID: 30721951, PMCID: PMC6497525, DOI: 10.1093/biolre/ioz014.Peer-Reviewed Original ResearchConceptsChronic diseasesReproductive-aged womenCommon chronic diseasesPathophysiology of endometriosisDisease-specific pathophysiologyRole of tissuePelvic painEndometriosis treatmentEndometriosisCandidate biomarkersPotential biomarkersNoninvasive toolSmall noncoding RNA moleculesDiseaseBiomarkersMultiple studiesPrecision medicineKey post-transcriptional regulatorsPathophysiologyNoncoding RNA moleculesMiRNA biomarkersDiagnosisMiRNA expressionFunctional pathwaysSpecific miRNAs
2015
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Seminars In Reproductive Medicine 2015, 33: 333-340. PMID: 26375413, PMCID: PMC4986990, DOI: 10.1055/s-0035-1564609.Peer-Reviewed Original ResearchConceptsStem cellsStem cell populationProgenitor stem cellsStem cell traffickingCyclic regenerationPool of cellsCell mobilityBone marrow-derived stem cellsMarrow-derived stem cellsDynamic organRecent characterizationUnrestrained growthCell populationsCell traffickingEctopic sitesCellsRapid regenerationHuman endometriumRegenerationPathologic roleGrowthEndometriosis interferesPathophysiology of endometriosisDevelopment of endometriosisTrafficking
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply