2025
Observational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82: 386-394. PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associations
2023
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
Koller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMAIN OUTCOMEMental healthIrritable bowel syndromeBody mass indexAssociation of endometriosisOdds of depressionSevere physical symptomsPain-related phenotypesWomen's mental healthMultivariate regression analysisOdds of endometriosisBowel syndromeGenetic associationMass indexGynecologic pathologyMillion Veteran ProgramEndometriosisPsychiatric disordersWomen's healthFemale controlsPleiotropic mechanismsPhysical symptomsComorbiditiesFinnGen study
2013
Genetic Polymorphisms Associated with Endometriosis in Pakistani Women
Liaqat I, Jahan N, Lone K, Pakstis A, Taylor H. Genetic Polymorphisms Associated with Endometriosis in Pakistani Women. Journal Of Endometriosis And Pelvic Pain Disorders 2013, 5: 134-143. DOI: 10.5301/je.5000165.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsProgesterone receptorGenetic variationGenomic variantsGenesGenetic variantsNucleotide polymorphismsHeritable predispositionMethods DNA samplesAssociation of endometriosisPakistani womenEstrogen receptor betaPathogenesis of endometriosisDNA samplesEstrogen receptor alphaRisk of endometriosisReceptor alphaFunctional promoter polymorphismPolymorphismEnvironmental factorsReceptor betaDirect sequencingEndometriosis subjectsBackground EndometriosisGenetic polymorphisms
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