2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2021
Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2018
Therapeutic strategies involving uterine stem cells in reproductive medicine
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine. Current Opinion In Obstetrics & Gynecology 2018, 30: 209-216. PMID: 29652725, DOI: 10.1097/gco.0000000000000457.Peer-Reviewed Original ResearchConceptsStem cell mobilizationMultipotent stem cellsEndometrial defectAsherman's syndromeStem cellsStem cell biologyEndometrial receptivity defectsLow estrogen levelsBone marrow-derived multipotent stem cellsInjury-induced expressionUterine stem cellsEndometriosis therapyProgenitor stem cellsEndometrial diseaseEstrogen levelsNormal endometriumOverwhelming injuryStem cell recruitmentMenstrual cycleEndometrial cellsStem cell traffickingReservoir of cellsCell recruitmentChemokine CXCL12Therapeutic strategies
2017
Stem cell therapies for atrophic endometrium and Asherman's syndrome
Seifer B, Naqvi H, Samani E, Krikun G, Taylor H. Stem cell therapies for atrophic endometrium and Asherman's syndrome. 2017, 217-227. DOI: 10.1201/9781315151472-16.Peer-Reviewed Original ResearchAsherman's syndromeAtrophic endometriumBone marrow stem cell transplantationMarrow stem cell transplantationCell therapyCommon clinical featuresStem cell transplantationNovel therapeutic approachesAvailability of providersStem cell therapyCommon pathologicIntrauterine synechiaeMenstrual irregularitiesClinical featuresCell transplantationNormal endometriumCase reportMurine modelTherapeutic approachesHuman studiesEndometriumSignificant injurySyndromeFibrous tissueNew stem cells
2016
Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma
Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS. Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2883-2891. PMID: 27088794, PMCID: PMC4929835, DOI: 10.1210/jc.2016-1795.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAntigens, CDCarcinoma, EndometrioidCells, CulturedEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMenstrual CycleMiddle AgedProtein SubunitsReceptor, IGF Type 1Receptor, InsulinTranscriptomeConceptsIGF-1R expressionEndometrial hyperplasiaNormal endometriumEndometrial physiologySecretory phaseProliferative phaseIGF-1 receptor mRNAIR-B expressionNormal secretory phaseType 2 diabetesSex steroid treatmentEarly secretory phaseEarly proliferative phaseNormal proliferative phaseEndometrial proliferationEndometrioid adenocarcinomaComplex hyperplasiaEndometrial adenocarcinomaMass indexMenstrual cycleRisk factorsReceptor expressionIGF-1RMAIN OUTCOMEReceptor mRNA
2014
Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndromeEndometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 2014, 155: 1489-1497. PMID: 24484171, PMCID: PMC3959601, DOI: 10.1210/en.2013-1977.Peer-Reviewed Original ResearchConceptsBZA/CEConjugated estrogensEndometriosis lesionsStem cell recruitmentCell engraftmentStem cell engraftmentCell recruitmentExperimental endometriosisEutopic endometriumUterine endometriumBone marrowSelective estrogen receptor modulator bazedoxifeneStem cellsMesenchymal stem cell engraftmentLesions of endometriosisMale bone marrowUteri of animalsBazedoxifene treatmentCell nuclear antigenEndometriosis interferesOvarian stimulationVehicle treatmentEndometrial functionNormal endometriumOvarian weight
2010
Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells
Penna IA, Du H, Kallen AN, Taylor HS. Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells. Reproductive Sciences 2010, 17: 471-476. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineEndometrial stromal cellsEndometrial stromal cell lineFirst trimester decidual cellsStromal cellsHuman endometrial stromal cellsEndometrial epithelial cell lineHuman endometrial epithelial cell lineFirst trimester deciduaVascular smooth muscle cellsReverse transcriptase-polymerase chain reactionQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionSmooth muscle cellsCell linesStromal cell growthG protein-coupled receptorsReproductive-age individualsEndometrial biopsyProtein-coupled receptorsEndometrial receptivityNormal endometriumDecidual samplesElective terminationEpithelial cell line
2008
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
Lee B, Du H, Taylor HS. Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1. Biology Of Reproduction 2008, 80: 79-85. PMID: 18799756, PMCID: PMC2804809, DOI: 10.1095/biolreprod.108.070391.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEndometriosisEndometriumFemaleGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryInsulin-Like Growth Factor Binding Protein 1Integrin beta ChainsKruppel-Like Transcription FactorsMiceReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndometriosis groupEndometrial receptivityEutopic endometriumExperimental endometriosisAltered gene expressionInsulin-like growth factorInduction of endometriosisKruppel-like factor 9Expression of HOXA10Total progesterone receptorEndometrial gene expressionBeta3 mRNA expressionProtein-1 mRNAReal-time RT-PCRQuantitative real-time RT-PCRGene expressionMurine endometriosisNormal endometriumProgesterone receptorMethylation-specific PCREndometriosisEndometriumMRNA expressionEctopic locationsGrowth factorEndometriosis and Tissue Factor
Krikun G, Schatz F, Taylor H, Lockwood CJ. Endometriosis and Tissue Factor. Annals Of The New York Academy Of Sciences 2008, 1127: 101-105. PMID: 18443336, PMCID: PMC3129033, DOI: 10.1196/annals.1434.008.Peer-Reviewed Original ResearchConceptsProtease-activated receptor 2Tissue factorTF expressionFactor VII/VIIaHigh TF expressionHemostatic cascadeChemokine productionInflammatory cytokinesNormal endometriumEctopic endometriumEutopic endometriumInflammatory environmentMacrophage recruitmentReceptor 2Therapeutic interventionsDisease resultsEndometriosisFactor VIIaEndometriumBlood coagulationMultiple cell typesCellular receptorsIdeal targetCell typesVIIa
2004
HOXA10 Expression in Endometrial Adenocarcinoma
Lane DB, Rutherford TJ, Taylor HS. HOXA10 Expression in Endometrial Adenocarcinoma. Tumor Biology 2004, 25: 264-269. PMID: 15627890, DOI: 10.1159/000081390.Peer-Reviewed Original ResearchConceptsEndometrial adenocarcinomaExpression of HOXA10Endometrial tissueHOXA10 expressionHOXA10 gene expressionNormal endometriumProgesterone receptorEstrogen receptorStage IEndometrial hyperplasiaNeoplastic endometriumGene expressionAdenocarcinomaAbnormal differentiationEndometriumReceptorsSignificant differencesNorthern blot analysisAdult reproductive tissuesBlot analysisHOXA10Aberrant regulationTissueP53Reproductive tissuesEMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis
Daftary GS, Taylor HS. EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 2390-2396. PMID: 15126568, DOI: 10.1210/jc.2003-031389.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinding SitesCells, CulturedDNA-Binding ProteinsEndometriosisEndometriumFemaleGene ExpressionGenitalia, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansMenstrual CycleOligonucleotides, AntisenseProtein Structure, TertiaryRNA, MessengerStromal CellsTranscription FactorsTranscription, GeneticConceptsEndometrium of patientsPeriimplantation endometriumHOXA10 expressionMenstrual cycle-dependent expressionPrimary endometrial stromal cellsStromal cellsEndometrial HOXA10 expressionAbsence of endometriosisEndometrial stromal cellsEMX2 expressionReproductive tract developmentFemale reproductive tractHOXA10 antisenseHOXA10 levelsNormal endometriumSex steroidsEndometriosisEndometriumPeriimplantation periodEndometrial HOXA10Proliferative phaseReproductive tractAberrant expressionTract developmentMRNA levels
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