2025
Use of AMD3100 for Bone Marrow Derived Mesenchymal Stem Cells Mobilization in the Treatment of Murine Asherman’s Syndrome
Flores V, Delis P, Mamillapalli R, Taylor H. Use of AMD3100 for Bone Marrow Derived Mesenchymal Stem Cells Mobilization in the Treatment of Murine Asherman’s Syndrome. F&S Science 2025 PMID: 40818715, DOI: 10.1016/j.xfss.2025.08.003.Peer-Reviewed Original ResearchAsherman's syndromePreterm ruptureAS inductionMurine modelProgenitor cellsMesenchymal stem cell mobilizationMice treated with AMD3100Preterm rupture of membranesAMD3100-treated miceRupture of membranesOptimal timingStem cell mobilizationBone marrow transplantationTreatment groupsLevels of CXCL12Source of progenitor cellsRecurrent pregnancy lossEndometrial progenitor cellsBMD-MSCsLikelihood of pregnancyHysteroscopic adhesiolysisPlacental abruptionUterine repairSevere ASMarrow transplantation
2022
Endometriosis promotes atherosclerosis in a murine model
Mamillapalli R, Toffoloni N, Habata S, Qunhua H, Atwani R, Stachenfeld N, Taylor HS. Endometriosis promotes atherosclerosis in a murine model. American Journal Of Obstetrics And Gynecology 2022, 227: 248.e1-248.e8. PMID: 35351413, PMCID: PMC9308711, DOI: 10.1016/j.ajog.2022.03.040.Peer-Reviewed Original ResearchConceptsEffect of endometriosisOil Red O stainingVascular endothelial growth factorMurine modelCardiovascular diseaseRed O stainingEndothelial growth factorSham miceEndometriotic lesionsInflammatory cytokinesInterleukin-6Luminal areaInterferon gammaO stainingGrowth factorAortic luminal areasInflammatory-related cytokinesRoot wall thicknessUnderwent sham surgeryTreatment of endometriosisInflammation-related cytokinesDevelopment of atherosclerosisApolipoprotein E (ApoE-/- ) miceLong-term riskWeeks of induction
2021
Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation
Mamillapalli R, Mutlu L, Taylor HS. Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation. Reproductive Sciences 2021, 29: 2382-2390. PMID: 34515983, DOI: 10.1007/s43032-021-00738-5.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsRecipient miceBone marrow-derived cellsProgenitor cellsBone marrow transplantMarrow-derived cellsMarrow-derived stem cellsSpecific uterine cell typesBone marrow-derived progenitorsMarrow-derived progenitorsUterine cell typesUpregulation of markersCell surface markersStem cellsSpecific stem cell markersStem cell markersCell typesUterine repairMarrow transplantStem cell componentUterine tissueMurine modelMaintenance of fertilityDifferentiation of BMSCsCell markersEndometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2019
Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency
Reig A, Mamillapalli R, Coolidge A, Johnson J, Taylor HS. Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency. Reproductive Sciences 2019, 26: 1633-1639. PMID: 31530098, PMCID: PMC6949960, DOI: 10.1177/1933719119875818.Peer-Reviewed Original ResearchConceptsEndometrial mesenchymal stem cellsPrimary ovarian insufficiencyOvarian functionOvarian insufficiencyMurine modelSerum anti-Müllerian hormone concentrationsAnti-Müllerian hormone concentrationsStem cellsStem cell therapyOvarian dysfunctionUterine cell suspensionsHormone concentrationsMesenchymal stem cellsUterine cellsChemotherapyYoung womenCell therapyMiceOocyte poolIncreased numberWomenHigher body massSignificant increaseInsufficiencyPupsmiR-45la Inhibition Reduces Established Endometriosis Lesions in Mice
Li M, Zhou Y, Taylor HS. miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice. Reproductive Sciences 2019, 26: 1506-1511. PMID: 31354069, DOI: 10.1177/1933719119862050.Peer-Reviewed Original ResearchConceptsMiR-451a inhibitorReproductive-age womenTreatment of endometriosisPro-inflammatory diseasesSystemic treatmentEndometriosis lesionsIL-6Chronic diseasesPromising therapyCurrent treatmentMicroRNA-451aMurine modelSex steroidsEndometriosisLesion sizeVisible lesionsMiR-451aMicroRNAs treatmentsDiseaseAltered expressionΒ-cateninTreatmentLesionsInhibitorsMultiple pathwaysDose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model
Rosa-e-Silva ACJS, Rosa-e-Silva JC, Mamillapalli R, Taylor HS. Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model. Reproductive Sciences 2019, 26: 1395-1400. PMID: 31274059, PMCID: PMC6949971, DOI: 10.1177/1933719119859438.Peer-Reviewed Original ResearchConceptsMurine modelCurrent clinical staging systemBurden of endometriosisClinical staging systemClear dose-response relationshipDegree of painStage of diseaseEffect of endometriosisMechanism of infertilityGroups of miceSequelae of diseaseSeverity of symptomsDose-response relationshipSham surgery controlsActive diseaseDisease activityPelvic painStaging systemEarly recognitionEctopic tissueEndometrial cellsGynecological diseasesSurgery controlsPregnancy rateUterine tissueEffects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study
Flores VA, Leone C, Taylor HS, Stachenfeld NS. Effects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study. Gynecological Endocrinology 2019, 35: 390-394. PMID: 30668182, DOI: 10.1080/09513590.2018.1559288.Peer-Reviewed Original ResearchConceptsBZA/CEPremenopausal womenConjugated estrogensReproductive hormonesUltrasonographic appearanceBazedoxifene/conjugated estrogensAbnormal ovarian folliculogenesisReproductive hormone changesCase series studyUnited States FoodEstrogen-receptor complexEndometrial alterationsDaily administrationSerum assessmentLH surgeMenopausal womenMenopausal symptomsMenstrual cycleClinical trialsEndocrinologic functionsOvarian morphologyHormone levelsPosttreatment valuesMurine modelOvarian folliculogenesis
2018
microRNA Let‐7b: A Novel treatment for endometriosis
Sahin C, Mamillapalli R, Yi KW, Taylor HS. microRNA Let‐7b: A Novel treatment for endometriosis. Journal Of Cellular And Molecular Medicine 2018, 22: 5346-5353. PMID: 30063121, PMCID: PMC6201226, DOI: 10.1111/jcmm.13807.Peer-Reviewed Original ResearchConceptsLet-7bSide effectsSystemic hormonal side effectsMicroRNA let‑7bReproductive-aged womenHormonal side effectsTreatment of endometriosisCurrent treatment optionsChronic inflammatory diseaseSteroid hormone modulationGrowth factor receptorIL-6Treatment optionsEndometriosis growthEndometriosis pathophysiologyInflammatory diseasesChronic diseasesLocal treatmentPromising therapyMurine modelEndometriosisHormone modulationNovel treatmentsLesion sizeMicroRNAs treatmentsG-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis
Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS. G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reproductive Sciences 2018, 25: 1168-1174. PMID: 29587613, PMCID: PMC6346303, DOI: 10.1177/1933719118766256.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsNormal endometrial epitheliumChronic inflammatory diseaseOverexpression of CXCR7Chemokine ligand CXCL12Chemokine G-protein-coupled receptorsMurine endometriosisDifferent cellular populationsHuman endometriosisInflammatory diseasesMenstrual cycleChemokine receptorsReceptor CXCR7Endometrial epitheliumEndometriosis pathogenesisLigand CXCL12Murine modelMouse modelEndometriosisHigher stainingCXCR7Human findingsCell traffickingLow expressionNovel targetIcon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis
Hufnagel D, Goetz L, Hu Z, Nyachieo A, D’Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis. Reproductive Biology 2018, 18: 109-114. PMID: 29422377, DOI: 10.1016/j.repbio.2018.01.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAdnexal DiseasesAmino Acid SubstitutionAnimalsEndometriosisFactor VIIFemaleGenetic TherapyGenetic VectorsHumansImmunoconjugatesImmunoglobulin Fc FragmentsImmunoglobulin GMolecular Targeted TherapyMutationNeovascularization, PathologicPapio anubisPelvisPeptide FragmentsRandom AllocationRecombinant Fusion ProteinsThromboplastinConceptsNon-human primatesNovel treatmentsTissue factorNon-human primate modelRegression of endometriosisEctopic endometrial tissueReproductive-aged womenEctopic endometrial lesionsWeekly intraperitoneal injectionsFactor VII/VIIaLesion vasculatureChronic painEndometrial lesionsEndometrial tissueEndometriosis lesionsLaparoscopic confirmationSurgical inductionIntraperitoneal injectionPrimate modelCommon conditionMurine modelEndometriosisTreatment groupsControl groupTreatment results
2017
Effect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alphaStem cell therapies for atrophic endometrium and Asherman's syndrome
Seifer B, Naqvi H, Samani E, Krikun G, Taylor H. Stem cell therapies for atrophic endometrium and Asherman's syndrome. 2017, 217-227. DOI: 10.1201/9781315151472-16.Peer-Reviewed Original ResearchAsherman's syndromeAtrophic endometriumBone marrow stem cell transplantationMarrow stem cell transplantationCell therapyCommon clinical featuresStem cell transplantationNovel therapeutic approachesAvailability of providersStem cell therapyCommon pathologicIntrauterine synechiaeMenstrual irregularitiesClinical featuresCell transplantationNormal endometriumCase reportMurine modelTherapeutic approachesHuman studiesEndometriumSignificant injurySyndromeFibrous tissueNew stem cellsMicrometastasis of endometriosis to distant organs in a murine model
Samani EN, Mamillapalli R, Li F, Mutlu L, Hufnagel D, Krikun G, Taylor HS. Micrometastasis of endometriosis to distant organs in a murine model. Oncotarget 2017, 10: 2282-2291. PMID: 31040919, PMCID: PMC6481344, DOI: 10.18632/oncotarget.16889.Peer-Reviewed Original ResearchPeritoneal cavityMultiple organsDistant organsDiffuse clinical manifestationsMurine endometriosis modelReproductive-aged womenDisseminated endometriosisEndometriosis modelRetrograde menstruationClinical manifestationsEndometrial tissueEndometriotic lesionsImmunocompetent miceFallopian tubeEndometrial cellsGynecological disordersMurine modelMouse modelEndometriosisExperimental animalsEngraftmentMicrometastasisImmunofluorescence analysisOrgansDiseaseCXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman’s Syndrome
Ersoy G, Zolbin MM, Cosar E, Moridi I, Mamillapalli R, Taylor HS. CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman’s Syndrome. Molecular Therapy — Methods & Clinical Development 2017, 4: 169-177. PMID: 28345002, PMCID: PMC5363300, DOI: 10.1016/j.omtm.2017.01.001.Peer-Reviewed Original ResearchAsherman's syndromeUterine repairBone marrow-derived mesenchymal stem cellsStem cell recruitmentCell recruitmentStem cell supplementationAdverse pregnancy outcomesTreatment of infertilityMarrow-derived mesenchymal stem cellsStem cell engraftmentCXCL12 administrationUterine fibrosisPregnancy outcomesUterine disordersUterine injuryReceptor antagonistReceptor agonistFunctional improvementMurine modelCXCL12 treatmentCell engraftmentLitter sizeCXCL12 productionMesenchymal stem cellsSyndrome
2016
Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2014
Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndrome
2012
Endometrial Stem Cells.
Taylor H. Endometrial Stem Cells. Biology Of Reproduction 2012, 87: 32-32. DOI: 10.1093/biolreprod/87.s1.32.Peer-Reviewed Original ResearchProgenitor stem cellsMesenchymal stem cellsUterine injuryMenstrual cycleMultipotent stem cellsStem cellsAdult progenitor stem cellsPathogenesis of endometriosisEndometrial stem cellsMurine diabetes modelPancreatic beta cellsAsherman's syndromeEndometrial regenerationDopaminergic neuronsDiabetes modelRetrograde fashionMurine modelPeritoneal cavitySex steroidsParkinson's diseaseBeta cellsBone marrowEndometriosisRemarkable regenerative capacityEctopic locationsA polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis
Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis. EMBO Molecular Medicine 2012, 4: 206-217. PMID: 22307873, PMCID: PMC3376847, DOI: 10.1002/emmm.201100200.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsKRAS-variantCultured endometrial stromal cellsStromal cellsAbnormal endometrial growthDe novo endometriosisProgesterone receptor levelsRelatives of womenEndometrial xenograftsKRAS resultsLCS6 polymorphismEndometrial growthReproductive ageKRAS mutationsReceptor levelsMurine modelEndometriosisEndometriosis riskControl populationVariant allelesKRAS mRNAProtein expressionKRASWomenKRAS protein
2011
Derivation of Insulin Producing Cells From Human Endometrial Stromal Stem Cells and Use in the Treatment of Murine Diabetes
Santamaria X, Massasa EE, Feng Y, Wolff E, Taylor HS. Derivation of Insulin Producing Cells From Human Endometrial Stromal Stem Cells and Use in the Treatment of Murine Diabetes. Molecular Therapy 2011, 19: 2065-2071. PMID: 21878900, PMCID: PMC3222529, DOI: 10.1038/mt.2011.173.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal stem cellsStromal stem cellsPancreatic islet cell transplantationStem cellsIslet cell transplantationType 1 diabetesBlood glucose levelsTreatment of murineDifferentiated cellsDiabetic miceCell transplantationKidney capsuleCadaveric donorsPotential therapeutic applicationsProgressive hyperglycemiaInsulin secretionMurine modelGlucose levelsUterine endometriumMesenchymal stem cellsΒ-cell markersInsulinHuman insulinGlucose-responsive mannerControl cells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply