2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cells
2023
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, Li D, Huang Y. Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production. Molecular Metabolism 2023, 78: 101828. PMID: 37898449, PMCID: PMC10641683, DOI: 10.1016/j.molmet.2023.101828.Peer-Reviewed Original ResearchConceptsFas-mediated apoptosisLet-7Hepatocyte apoptosisNegative feedback loopMouse primary hepatocytesLet-7 miRNAsTGF-b signalingSignaling networksApoptosis of hepatocytesTransient transfectionFAS expressionInhibiting hepatocyte apoptosisSiRNA knockdownLet-7 expressionLet-7 overexpressionMouse modelApoptosisPrimary hepatocytesSuppressed hepatocyte apoptosisTET3Liver fibrosisFeedback loopExpressionDriver of liver fibrosisAdeno-associated viral vectors
2022
Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis
Rosa-E-Silva ACJS, Mamillapalli R, Rosa-E-Silva JC, Ucar A, Schwartz J, Taylor HS. Uterine administration of C-X-C motif chemokine ligand 12 increases the pregnancy rates in mice with induced endometriosis. F&S Science 2022, 4: 65-73. PMID: 36252793, DOI: 10.1016/j.xfss.2022.10.003.Peer-Reviewed Original ResearchConceptsC motif chemokine ligand 12Endometriosis groupPregnancy rateChemokine ligand 12Alpha v beta 3 integrinUterine injectionBeta 3 integrinBMDC recruitmentProgesterone receptorMouse modelBone marrow-derived cell recruitmentHigher cumulative pregnancy rateLigand 12Therapeutic agentsEndometrial receptivity defectsCumulative pregnancy rateEndometrial receptivity markersSham surgery groupBone marrow transplantationLower pregnancy ratesAcademic medical centerPotential therapeutic agentReceptivity markersSurgery groupInduced endometriosisTET3 epigenetically controls feeding and stress response behaviors via AGRP neurons
Xie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y. TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. Journal Of Clinical Investigation 2022, 132: e162365. PMID: 36189793, PMCID: PMC9525119, DOI: 10.1172/jci162365.Peer-Reviewed Original ResearchConceptsAgRP neuronsNeuropeptide YExpression of AgRPControl of feedingHypothalamic agoutiAnxiolytic effectsNeurotransmitter GABAMouse modelLeptin signalingStress-like behaviorsGenetic ablationNeuronsAgRPCritical central regulatorsEnergy expenditureGABAEnergy metabolismAppetiteFeedingCentral regulatorMetabolismCentral controlHuman cellsTET3ObesityLet-7 underlies metformin-induced inhibition of hepatic glucose production
Xie D, Chen F, Zhang Y, Shi B, Song J, Chaudhari K, Yang SH, Zhang GJ, Sun X, Taylor HS, Li D, Huang Y. Let-7 underlies metformin-induced inhibition of hepatic glucose production. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122217119. PMID: 35344434, PMCID: PMC9169108, DOI: 10.1073/pnas.2122217119.Peer-Reviewed Original ResearchConceptsHepatic glucose productionAntidiabetic effectsMouse modelGlucose productionPotent antidiabetic actionsHepatocyte nuclear factor 4 alphaNuclear factor 4 alphaFunction mouse modelsHuman primary hepatocytesMetformin-induced inhibitionAntidiabetic actionTherapeutic effectGlucose homeostasisSuprapharmacological concentrationsRelevant dosesHepatic deliveryMetforminFetal isoformsPotential therapeuticsPrimary hepatocytesMost studiesLet-7Regulatory pathwaysHyperglycemiaDiabetes
2021
Genetics of agenesis/hypoplasia of the uterus and vagina: narrowing down the number of candidate genes for Mayer–Rokitansky–Küster–Hauser Syndrome
Mikhael S, Dugar S, Morton M, Chorich LP, Tam KB, Lossie AC, Kim HG, Knight J, Taylor HS, Mukherjee S, Capra JA, Phillips JA, Friez M, Layman LC. Genetics of agenesis/hypoplasia of the uterus and vagina: narrowing down the number of candidate genes for Mayer–Rokitansky–Küster–Hauser Syndrome. Human Genetics 2021, 140: 667-680. PMID: 33469725, PMCID: PMC9211441, DOI: 10.1007/s00439-020-02239-y.Peer-Reviewed Original ResearchConceptsKüster-Hauser syndromeMouse modelHuman studiesCandidate variantsAgenesis/hypoplasiaMethodsWhole-exome sequencingMayer-RokitanskyCandidate genesCongenital absenceExome sequencingAuditory defectsSanger sequencingPatientsRare variantsSyndromeUterusMRKHVaginaFurther investigationDigenic combinationsPhysiological candidatesGenetic basisSame geneVariant analysisGenes
2020
Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring
Wang Z, Alderman MH, Asgari C, Taylor HS. Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring. Endocrinology 2020, 161: bqaa164. PMID: 32926169, PMCID: PMC7609133, DOI: 10.1210/endocr/bqaa164.Peer-Reviewed Original ResearchConceptsUtero exposureLocomotor activityUtero bisphenol A (BPA) exposureBisphenol A (BPA) exposureSignificant decreaseAnxiety-like behaviorDeclarative memory impairmentSex-specific mannerA ExposureFemale miceMale miceBPA exposureRelevant doseMotor coordinationMouse modelMurine behaviourControl animalsNeurobehavioral functionBPA treatmentLocomotor deficitsMemory impairmentOlder ageBrain developmentLong-term memoryBrain gene expressionEndometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells. Reproductive Sciences 2020, 28: 426-434. PMID: 32812213, DOI: 10.1007/s43032-020-00294-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCDC2 Protein KinaseCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLParacrine CommunicationSignal TransductionStromal CellsConceptsBone marrow-derived stem cellsCell proliferationEndometrial cellsEstrogen-dependent gynecological disorderPrimary endometrial stromal cellsEndometrial stromal cell proliferationEndometriosis cell proliferationReproductive-aged womenEndometrial stromal cellsNormal endometrial cellsEndometrial cell proliferationMarrow-derived stem cellsNovel therapeutic strategiesStromal cell proliferationBone marrow mesenchymal stem cellsStem cellsSignificant clonal expansionMarrow mesenchymal stem cellsPelvic painEndometriotic lesionsEndometriosis growthGynecological disordersEndometriosis cell linesMouse modelEndometriosisHepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
Da Li, Cao T, Sun X, Jin S, Di Xie, Huang X, Yang X, Carmichael GG, Taylor HS, Diano S, Huang Y. Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform. Nature Communications 2020, 11: 342. PMID: 31953394, PMCID: PMC6969024, DOI: 10.1038/s41467-019-14185-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2DioxygenasesDisease Models, AnimalDNA DemethylationDNA MethylationDNA-Binding ProteinsFastingGene Expression RegulationGlucagonGlucoseHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 4LiverMaleMiceMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticProtein IsoformsTranscriptional ActivationTranscriptomeUp-RegulationConceptsHepatic glucose productionType 2 diabetesGlucose homeostasisAdult liverSystemic glucose homeostasisPotential therapeutic targetGenetic mouse modelsFetal versionKey gluconeogenic genesMouse modelTherapeutic targetHNF4α functionGlucose productionFetal isoformsLiverT2D.DiabetesPromoter demethylationGluconeogenic genesTET3 overexpressionHNF4αHomeostasisTET3Regulatory mechanismsIsoforms
2019
Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression
Zolbin MM, Mamillapalli R, Nematian SE, Goetz T, Taylor HS. Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression. Reproductive Biology And Endocrinology 2019, 17: 36. PMID: 30982470, PMCID: PMC6463663, DOI: 10.1186/s12958-019-0480-0.Peer-Reviewed Original ResearchConceptsBody mass indexFat metabolismFat tissueMouse modelAdipose tissueMetabolic gene expressionLower body mass indexOld female C57BL/6 miceAdipocytes of womenMicroRNA let‑7bSerum of womenReproductive-aged womenEffect of endometriosisFemale C57BL/6 miceStem cellsAdipose-derived mesenchymal stem cellsBrown adipocyte differentiationInhibitors of microRNAsStem cell contentMass indexMetabolic abnormalitiesC57BL/6 miceInflammatory disordersIL-6Insulin sensitivityEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Characterization of cell fusion in an experimental mouse model of endometriosis†
Tal A, Tal R, Shaikh S, Gidicsin S, Mamillapalli R, Taylor H. Characterization of cell fusion in an experimental mouse model of endometriosis†. Biology Of Reproduction 2018, 100: 390-397. PMID: 30304517, PMCID: PMC7302516, DOI: 10.1093/biolre/ioy221.Peer-Reviewed Original ResearchConceptsMouse modelLimited proliferative activityFunctional endometrial tissueBone marrow transplantation modelExperimental mouse modelEndometrial stem cellsPrincipal cell sourceRepair/regeneration processBone marrow cellsEndometriosis shareCell fusionEndometrial tissueEndometriosis lesionsEndometriotic lesionsUterine cavityTransplantation modelCell fusion eventsCre-lox systemEndometriosisEpithelial markersStromal compartmentLesionsMarrow cellsProliferative activitySca-1Uterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceBone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
Yi KW, Mamillapalli R, Sahin C, Song J, Tal R, Taylor HS. Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model. Biology Of Reproduction 2018, 100: 61-70. PMID: 30084961, PMCID: PMC6335209, DOI: 10.1093/biolre/ioy175.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsThin endometriumEndometrial regenerationComparable efficacyTherapeutic effectC motif chemokine 12Potential therapeutic effectsMatrix metalloproteinase-2MRNA expression levelsLeukemia inhibitory factorIntegrin beta 3Endometrial growthEndometrial receptivityCD31 immunoreactivityInterleukin-1βPregnancy rateKi-67Mouse modelEpithelial areaSuccessful implantationMetalloproteinase-2EndometriumCXCL12Inhibitory factorG-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis
Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS. G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reproductive Sciences 2018, 25: 1168-1174. PMID: 29587613, PMCID: PMC6346303, DOI: 10.1177/1933719118766256.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsNormal endometrial epitheliumChronic inflammatory diseaseOverexpression of CXCR7Chemokine ligand CXCL12Chemokine G-protein-coupled receptorsMurine endometriosisDifferent cellular populationsHuman endometriosisInflammatory diseasesMenstrual cycleChemokine receptorsReceptor CXCR7Endometrial epitheliumEndometriosis pathogenesisLigand CXCL12Murine modelMouse modelEndometriosisHigher stainingCXCR7Human findingsCell traffickingLow expressionNovel target
2017
Micrometastasis of endometriosis to distant organs in a murine model
Samani EN, Mamillapalli R, Li F, Mutlu L, Hufnagel D, Krikun G, Taylor HS. Micrometastasis of endometriosis to distant organs in a murine model. Oncotarget 2017, 10: 2282-2291. PMID: 31040919, PMCID: PMC6481344, DOI: 10.18632/oncotarget.16889.Peer-Reviewed Original ResearchPeritoneal cavityMultiple organsDistant organsDiffuse clinical manifestationsMurine endometriosis modelReproductive-aged womenDisseminated endometriosisEndometriosis modelRetrograde menstruationClinical manifestationsEndometrial tissueEndometriotic lesionsImmunocompetent miceFallopian tubeEndometrial cellsGynecological disordersMurine modelMouse modelEndometriosisExperimental animalsEngraftmentMicrometastasisImmunofluorescence analysisOrgansDisease
2013
Erratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad T, Gan G, Gao X, Taylor H. Erratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2013, 3: 1320. PMCID: PMC3575011, DOI: 10.1038/srep01320.Peer-Reviewed Original ResearchMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
2012
Simvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1. Biology Of Reproduction 2012, 87: 2, 1-6. PMID: 22492974, PMCID: PMC3406552, DOI: 10.1095/biolreprod.111.098806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEndometriosisEndometriumFemaleGene ExpressionHumansHyaluronan ReceptorsHydroxymethylglutaryl-CoA Reductase InhibitorsMatrix Metalloproteinase 2Matrix Metalloproteinase 3MiceMice, NudePolyisoprenyl PhosphatesPrenylationSesquiterpenesSimvastatinStromal CellsTissue Inhibitor of Metalloproteinase-2ConceptsEffect of simvastatinMatrix metalloproteinase-2Metalloproteinase-2Human endometrial stromal cellsEndometrial stromal cellsNude mouse modelConcentration-dependent reductionInhibition of HMGCREffects of GGPPInhibition of geranylgeranylationEndometrial implantsEndometrial stromaSimvastatin treatmentMouse modelAnimal modelsTissue inhibitorTIMP2 mRNASimvastatinDecrease invasivenessDecrease proliferationStromal cellsPresence of GGppCell invasivenessMRNA levelsEndometriosisStatins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis
Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis. Reproductive Sciences 2012, 19: 572-579. PMID: 22267540, PMCID: PMC3439122, DOI: 10.1177/1933719111430998.Peer-Reviewed Original ResearchConceptsCultured endometriotic cellsMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionMCP-1 productionEndometriotic cellsProtein-1 expressionEndometriotic implantsMouse modelMCP-1 messenger RNA expressionExerts anti-inflammatory effectsAnti-inflammatory effectsEffect of statinsAnti-inflammatory propertiesMCP-1 expressionMevalonate pathwayDose-dependent inhibitionNude mouse modelMessenger RNA expressionDose-dependent mannerEctopic endometriumEndometrial cellsPeritoneal surfaceStatinsPotential treatmentInhibitory effectFetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad TS, Gan G, Gao XB, Taylor HS. Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2012, 2: 312. PMID: 22428084, PMCID: PMC3306017, DOI: 10.1038/srep00312.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
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