2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2021
Molecular mechanisms of estrogen action in female genital tract development
Alderman MH, Taylor HS. Molecular mechanisms of estrogen action in female genital tract development. Differentiation 2021, 118: 34-40. PMID: 33707128, PMCID: PMC8073215, DOI: 10.1016/j.diff.2021.01.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expressionSelective estrogen receptor modulatorsFemale genital tract developmentAberrant CpG methylationGenital tract developmentHistone modificationsEpigenetic regulationOrgan developmentCpG methylationTranscriptional pathwaysSpecific fetalEpigenetic modulationMolecular mechanismsFemale reproductive tractLate organogenesisHormonal regulationOrganogenesisEstrogen receptor modulatorsTract developmentReproductive tractIndependent fashionRegulationDisease statesEstrogen actionReceptor modulators
2018
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia
Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. JCI Insight 2018, 3: e120304. PMID: 29769440, PMCID: PMC6012507, DOI: 10.1172/jci.insight.120304.Peer-Reviewed Original ResearchConceptsHepatic glucose productionGenome-wide methylationExpression of Hnf4aGluconeogenic transcription factorsDiabetic hyperglycemiaH19 depletionTranscriptome analysisTranscription factorsExpression of H19Molecular mechanismsDiet-induced diabetic miceExcessive hepatic glucose productionType 2 diabetesInsulin-dependent suppressionElevated hepatic expressionH19 knockdownH19Promoter methylationMechanistic explanationMethylationDiabetic patientsRNADiabetic miceInsulin resistanceH19 overexpression
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSCMetformin alters DNA methylation genome-wide via the H19/SAHH axis
Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y. Metformin alters DNA methylation genome-wide via the H19/SAHH axis. Oncogene 2016, 36: 2345-2354. PMID: 27775072, PMCID: PMC5415944, DOI: 10.1038/onc.2016.391.Peer-Reviewed Original ResearchConceptsS-adenosylhomocysteine hydrolaseDNA methylation genomeGenome-wide alterationsNovel mechanismSubset of genesDNA methyltransferase 3BMethylation genomeDNA methylationEpigenetic dysregulationPathway genesMolecular basisAMPK activationLet-7Methyltransferase 3BMolecular mechanismsEndometrial cancer tissue samplesH19 knockdownGene methylationCell proliferationCancer tissue samplesCancer cellsNormal cellsConcomitant inhibitionGenesMethylationAberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes
Kulp JL, Mamillapalli R, Taylor HS. Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes. Reproductive Sciences 2016, 23: 455-463. PMID: 26865543, PMCID: PMC5933190, DOI: 10.1177/1933719116630427.Peer-Reviewed Original ResearchConceptsHOXA10 geneCommon molecular mechanismDNA methylationTranscription factorsMethylation patternsMolecular mechanismsFemale reproductive tractCpG sitesAberrant methylationMethylationGenesMessenger RNACommon gynecologic disorderExpression of HOXA10Endometrium of uterusEmbryonic signalsCertain disease statesAdult endometriumSubmucosal myomasUterine myomaAsherman's syndromeEndometrial receptivityIntramural myomasUterine septumGynecologic disease
2015
H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis
Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.Peer-Reviewed Original ResearchConceptsChronic pelvic painReproductive-aged womenEndometrium of womenEndometrial stromal cellsStromal cell growthEndometrial preparationPelvic painEutopic endometriumAged womenEndometriosisNormal controlsStromal cellsH19 expressionImpact fertilityMolecular spongeH19/letNovel therapeuticsReduced proliferationInfertilityWomenEndometriumTurn inhibitsMicroRNA let-7Molecular mechanismsCell growth
2011
Endometrial polyps affect uterine receptivity
Rackow BW, Jorgensen E, Taylor HS. Endometrial polyps affect uterine receptivity. Fertility And Sterility 2011, 95: 2690-2692. PMID: 21269620, PMCID: PMC3096716, DOI: 10.1016/j.fertnstert.2010.12.034.Peer-Reviewed Original Research
2010
The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review
Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, Baracat EC, Serafini PC. The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. Journal Of Assisted Reproduction And Genetics 2010, 27: 701-710. PMID: 20821045, PMCID: PMC2997955, DOI: 10.1007/s10815-010-9471-y.Peer-Reviewed Original ResearchConceptsHOXA10 expressionAspects of endometriosisHomeobox A10 (HOXA10) geneWindow of implantationEtiology of endometriosisRetrograde menstruation theoryMüllerian tractSurgical treatmentRelated infertilityEndometrial expressionEndometriotic fociLaboratory findingsEmbryo implantationEndometriosisInfertilityHOXA10 geneMethodsThis reviewEtiologyHOXA10DiseasePeak of expressionMolecular mechanismsRecent studiesImplantation
2008
Gene Expression Profiling Reveals Putative HOXA10 Downstream Targets in the Periimplantation Mouse Uterus
Vitiello D, Pinard R, Taylor HS. Gene Expression Profiling Reveals Putative HOXA10 Downstream Targets in the Periimplantation Mouse Uterus. Reproductive Sciences 2008, 15: 529-535. PMID: 18579861, PMCID: PMC3107854, DOI: 10.1177/1933719108316911.Peer-Reviewed Original ResearchConceptsMicroarray analysisHoxA10 target geneSignal transduction factorsGene expression profilingTumor-associated calcium signal transducer 2Calcium signal transducer 2Transcription factorsHOXA10 expressionTarget genesCell adhesion moleculeCandidate genesExpression profilingCellular ontogenyDownstream targetsMolecular mechanismsSignificant genesMolecular markersPeriimplantation mouse uterusTransduction factorsGenesHOXA10 overexpressionMetabolic regulatorFurther characterizationAdhesion moleculesReal-time reverse transcriptase-polymerase chain reactionEndocrine Disruptors Alter HOX Gene Expression in the Reproductive Tract.
Taylor H. Endocrine Disruptors Alter HOX Gene Expression in the Reproductive Tract. Biology Of Reproduction 2008, 78: 232-233. DOI: 10.1093/biolreprod/78.s1.232b.Peer-Reviewed Original ResearchHox gene expressionEssential developmental genesHox genesGene expressionEstrogen response elementHOXA10 estrogen response elementDevelopmental genesPositional identityDevelopmental identityDevelopmental programmingMolecular mechanismsFemale reproductive tractParticular Hox genesReproductive tractHox codeMüllerian ductsAxial identityDevelopment genesEstrogen-responsive genesSegment identityExpression domainsReproductive successResponsive genesTranscription factorsNormal patterning
2007
HOX Genes in Implantation
Vitiello D, Kodaman P, Taylor H. HOX Genes in Implantation. Seminars In Reproductive Medicine 2007, 25: 431-436. PMID: 17960527, DOI: 10.1055/s-2007-991040.Peer-Reviewed Original Research
2006
An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells
Kelly M, Daftary G, Taylor HS. An autoregulatory element maintains HOXA10 expression in endometrial epithelial cells. American Journal Of Obstetrics And Gynecology 2006, 194: 1100-1107. PMID: 16580301, DOI: 10.1016/j.ajog.2005.12.025.Peer-Reviewed Original ResearchConceptsEndometrial epithelial cellsHOXA10 expressionProgesterone receptorAutoregulatory elementRegulatory regionsEpithelial cellsGene expressionBT-20 cellsSteroid-induced gene expressionReporter gene expressionEndometrial receptivityIshikawa cellsSex steroidsBase pair elementSteroid receptorsAlternative molecular mechanismsStromal cellsHOXA10 proteinReporter constructsExpression increasesMolecular mechanismsReceptorsReporter activityDirect bindingHOXA10
2004
A HOXA10 Estrogen Response Element (ERE) is Differentially Regulated by 17 Beta-estradiol and Diethylstilbestrol (DES)
Akbas GE, Song J, Taylor HS. A HOXA10 Estrogen Response Element (ERE) is Differentially Regulated by 17 Beta-estradiol and Diethylstilbestrol (DES). Journal Of Molecular Biology 2004, 340: 1013-1023. PMID: 15236964, DOI: 10.1016/j.jmb.2004.05.052.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCell Line, TumorCell NucleusDiethylstilbestrolDNA-Binding ProteinsElectrophoretic Mobility Shift AssayEstradiolEstrogen Receptor alphaEstrogen Receptor betaGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsHumansLigandsProtein BindingReceptors, EstrogenResponse ElementsSubstrate SpecificityConceptsEstrogen response elementHOXA10 estrogen response elementConsensus estrogen response elementHox gene expressionHOXA10 geneEndometrial adenocarcinoma cell lineMolecular mechanismsSRC-1Ligand-specific activationGene expressionMüllerian duct differentiationReporter activityAdenocarcinoma cell lineFemale reproductive tractReporter expressionLigand specificityLuciferase reporter activityIshikawa cellsResponse elementEstrogen regulationEstrogen diethylstilbestrolHOXA10 expressionDevelopmental gene expressionDevelopmental anomaliesDuct differentiation
2002
Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression
Daftary GS, Taylor HS. Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression. Fertility And Sterility 2002, 78: 577-580. PMID: 12215336, DOI: 10.1016/s0015-0282(02)03306-x.Peer-Reviewed Original ResearchConceptsHOXA10 mRNA expressionHydrosalpinx fluidMRNA expressionMinimum essential mediumHOXA10 expressionExpression of HOXA10Academic medical centerPotential molecular mechanismsBilateral hydrosalpinxEndometrial receptivityImplantation rateEndometrial cellsIshikawa cellsEssential mediumMedical CenterMAIN OUTCOMEMurine modelNorthern blotPatientsHOXA10Total RNAMolecular mechanismsBlotDensitometric analysisCells
2000
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system
Block K, Kardana A, Igarashi P, Taylor H. In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system. The FASEB Journal 2000, 14: 1101-1108. PMID: 10834931, DOI: 10.1096/fasebj.14.9.1101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell LineCycloheximideDiethylstilbestrolEstradiolFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGenitalia, FemaleHomeodomain ProteinsHumansIn Situ HybridizationLitter SizeMaleMiceMullerian DuctsOvaryPregnancyPrenatal Exposure Delayed EffectsRNA, MessengerTeratogensUterusVaginaConceptsHox gene expressionHox genesGene expressionExpression patternsPosterior Hox genesAnterior Hox genesReproductive tractAnterior transformationAcid regulationMolecular mechanismsReproductive tract developmentGenesHOXA10 gene expressionTract developmentExpressionCell culturesMullerian systemPregnant womenAnatomic abnormalitiesFemale offspringDrug usePosterior shiftPotential markerLater stagesMorphogens
1997
A Conserved Hox Axis in the Mouse and Human Female Reproductive System: Late Establishment and Persistent Adult Expression of the Hoxa Cluster Genes
Taylor H, Heuvel G, Igarashi P. A Conserved Hox Axis in the Mouse and Human Female Reproductive System: Late Establishment and Persistent Adult Expression of the Hoxa Cluster Genes. Biology Of Reproduction 1997, 57: 1338-1345. PMID: 9408238, DOI: 10.1095/biolreprod57.6.1338.Peer-Reviewed Original ResearchConceptsHox genesHoxa-9Hoxa-13Hoxa-11Mammalian female reproductive systemFemale reproductive systemHOXA cluster genesTiming of geneHuman female reproductive systemReproductive systemTemporal colinearitySpatial colinearityCluster genesLate establishmentDevelopmental plasticityExpression patternsMolecular mechanismsParamesonephric ductsHOXA-10GenesAdult expressionEmbryonic miceColinearityPersistent expressionMüllerian tract
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