2025
Effect of endometriosis-linked microRNAs on hepatic gene expression
Mamillapalli R, Slutzky R, Mangla A, Gawde N, Taylor H. Effect of endometriosis-linked microRNAs on hepatic gene expression. F&S Science 2025, 6: 221-231. PMID: 39971156, DOI: 10.1016/j.xfss.2025.02.001.Peer-Reviewed Original ResearchMiR-3613-5pMiR-let-7bMiR-125b-5pMiR-150MiR-150-5pCirculating microRNAsMicroRNAsReactionExpression of IGFBP1Quantitative polymerase chain reactionSuppress target genesExpression of MRC1Polymerase chain reactionBinding sitesReal-time quantitative polymerase chain reactionHepatic gene expressionExpression of CYP2R1Bioinformatics analysisEffect of endometriosisSerum of womenCirculation of womenGene expressionChain reactionMiRsHepatic cells
2024
Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation
Bonavina G, Mamillapalli R, Krikun G, Zhou Y, Gawde N, Taylor H. Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation /regeneration/ and inhibit differentiation. Stem Cell Research & Therapy 2024, 15: 129. PMID: 38693588, PMCID: PMC11064399, DOI: 10.1186/s13287-024-03716-1.Peer-Reviewed Original ResearchConceptsMiR-100-5pMiR-100MiR-21Transmission electron microscopyMiR-143MiR-143-3pMiR-21-5pEndometrial stromal fibroblastsStromal fibroblastsMicroRNAsExtracellular vesiclesElectron microscopyCell-free regenerative therapyNanoparticle tracking analysisMiRNAsBone marrow mesenchymal stem cell-derived exosomesBone marrow-derived stem cellsMesenchymal stem cell-derived exosomesStem cell-derived exosomesDelivery of microRNAsMarrow-derived stem cellsAssociated with several signaling pathwaysMediators of tissue repairMethodsExtracellular vesiclesUnpaired t-test
2014
The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells
Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research 2014, 42: 13799-13811. PMID: 25399420, PMCID: PMC4267628, DOI: 10.1093/nar/gku1160.Peer-Reviewed Original ResearchConceptsDouble-negative feedback loopLet-7PI3K/Akt-dependent phosphorylationLet-7 targetsHuman genetic disordersAkt-dependent phosphorylationMuscle cellsInsulin-resistant rodentsSponge lncRNAsMolecular spongeH19 lncRNAFeedback loopGrowth controlDepletion resultsH19Impaired insulinLncRNAsTarget miRNAGlucose uptakeGenetic disordersBiogenesisCellsKSRPPhosphorylationMicroRNAsMicroRNA and gynecological reproductive diseases
Santamaria X, Taylor H. MicroRNA and gynecological reproductive diseases. Fertility And Sterility 2014, 101: 1545-1551. PMID: 24882618, DOI: 10.1016/j.fertnstert.2014.04.044.Peer-Reviewed Original ResearchConceptsSmall non-coding RNAsTranslation of mRNAsNon-coding RNAsAberrant miRNA expressionHuman diseasesMiRNA expressionAbnormal expressionMicroRNAsReproductive tract diseaseReproductive diseasesExpressionGenesMiRNAsMiRNARNATranslationMRNATherapeutic toolDysregulationGynecological diseasesInflammatory diseases
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