2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDisease
2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2019
Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency
Reig A, Mamillapalli R, Coolidge A, Johnson J, Taylor HS. Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency. Reproductive Sciences 2019, 26: 1633-1639. PMID: 31530098, PMCID: PMC6949960, DOI: 10.1177/1933719119875818.Peer-Reviewed Original ResearchConceptsEndometrial mesenchymal stem cellsPrimary ovarian insufficiencyOvarian functionOvarian insufficiencyMurine modelSerum anti-Müllerian hormone concentrationsAnti-Müllerian hormone concentrationsStem cellsStem cell therapyOvarian dysfunctionUterine cell suspensionsHormone concentrationsMesenchymal stem cellsUterine cellsChemotherapyYoung womenCell therapyMiceOocyte poolIncreased numberWomenHigher body massSignificant increaseInsufficiencyPupsCD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMiceBone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus
Tal R, Dong D, Shaikh S, Mamillapalli R, Taylor HS. Bone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus. Biology Of Reproduction 2019, 100: 1228-1237. PMID: 30601943, PMCID: PMC6497522, DOI: 10.1093/biolre/ioy265.Peer-Reviewed Original ResearchConceptsEndothelial progenitor cellsPregnant uterusImplantation sitesPregnant miceBM-derived endothelial progenitor cellsProgenitor cellsEarly pregnant uterusUterine implantation sitesContribution of BMNew blood vesselsEndometrial growthBM transplantationEndothelial cell populationEndometrial vasculaturePregnancy maintenanceDecidual vasculatureMouse recipientsGestational dayVascular endotheliumEndothelial-specific promoterBone marrowTransgenic miceMouse deciduaFlow cytometryMice
2018
Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury
Sahin C, Mamillapalli R, Taylor HS. Bone Marrow-Derived Cells Trafficking to the Oviduct: Effect of Ischemia-Reperfusion Injury. Reproductive Sciences 2018, 25: 1037-1044. PMID: 29658434, PMCID: PMC6346346, DOI: 10.1177/1933719118770552.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsRecruitment of BMDCsMarrow-derived cellsReperfusion injuryFallopian tubeFemale miceWild-type female miceIschemia-reperfusion injuryEquivalent surgeryIR injuryBMDC recruitmentMale miceBone marrowMammalian reproductive tractInjuryIschemiaReproductive tractMiceHealing processEarly embryo developmentOviductCrucial organCellsCritical roleRecruitmentEndometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†
Li T, Mamillapalli R, Ding S, Chang H, Liu ZW, Gao XB, Taylor HS. Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†. Biology Of Reproduction 2018, 99: 349-359. PMID: 29425272, PMCID: PMC6692844, DOI: 10.1093/biolre/ioy035.Peer-Reviewed Original ResearchConceptsEffect of endometriosisPain sensitizationPain perceptionBrain electrophysiologyEstrogen-dependent inflammatory disorderReproductive-aged womenDetection of endometriosisRegions of brainPatch-clamp recordingsCentral sensitizationPelvic painGene expressionInflammatory disordersEndometriosis miceFemale miceSham controlsMood disordersEndometriosisPainClamp recordingsBehavioral testsMiceBrain gene expressionSensitizationElectrophysiology
2017
Endometriosis alters anxiety, depression and pain perception as well as brain electrophysiology and gene expression in mice
Mamillapalli R, Gao X, Taylor H. Endometriosis alters anxiety, depression and pain perception as well as brain electrophysiology and gene expression in mice. Fertility And Sterility 2017, 108: e43-e44. DOI: 10.1016/j.fertnstert.2017.07.142.Peer-Reviewed Original Research
2016
Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1
Goetz L, Mamillapalli R, Taylor HS. Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1. Biology Of Reproduction 2016, 95: 115, 1-8. PMID: 27628219, PMCID: PMC5315422, DOI: 10.1095/biolreprod.116.142877.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody Mass IndexBody WeightCholestanetriol 26-MonooxygenaseDisease Models, AnimalDown-RegulationEndometriosisEndometriumFatty Acid-Binding ProteinsFemaleGene Expression ProfilingInsulin-Like Growth Factor Binding Protein 1LiverMembrane GlycoproteinsMicePeritoneal DiseasesReceptors, Cell SurfaceReceptors, Immunologicrho-Associated KinasesUp-RegulationConceptsLower body mass indexBody mass indexMass indexBody fatBody weightDual-energy X-ray absorptiometry scanningLower total body fatEffect of endometriosisTotal body fatLower body weightLiver of miceExpression levelsHepatic gene expressionLiver gene expressionMultiorgan natureMouse endometriumEndometrial cellsFemale miceGene expressionPeritoneal cavityEndometriosisDisease endometriosisMiceWeight lossKey metabolic genesA Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction
Tal R, Liu Y, Pluchino N, Shaikh S, Mamillapalli R, Taylor H. A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction. Endocrinology 2016, 157: 3749-3759. PMID: 27427897, PMCID: PMC6285241, DOI: 10.1210/en.2016-1418.Peer-Reviewed Original ResearchConceptsStem cell factorDonor chimerismOvarian functionBone marrowIntact ovarian functionGreen fluorescent protein miceTransgenic green fluorescent protein (GFP) miceEndometrial regenerationRegimen resultsEndometrial stromaControl miceTransplant modelBM cellsBMDCsCTX-1CD31 stainingImmunohistochemical analysisDay 28Cell traffickingUterine cellsUterusBMTCD45 markersMiceCytometry analysisEndometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2013
Erratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad T, Gan G, Gao X, Taylor H. Erratum: CORRIGENDUM: Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2013, 3: 1320. PMCID: PMC3575011, DOI: 10.1038/srep01320.Peer-Reviewed Original ResearchMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
2012
Migration of Cells from Experimental Endometriosis to the Uterine Endometrium
Santamaria X, Massasa EE, Taylor HS. Migration of Cells from Experimental Endometriosis to the Uterine Endometrium. Endocrinology 2012, 153: 5566-5574. PMID: 22968642, PMCID: PMC3473215, DOI: 10.1210/en.2012-1202.Peer-Reviewed Original ResearchConceptsEutopic endometriumEctopic lesionsEndometrial tissueExperimental endometriosisGreen fluorescent protein miceEstrogen-dependent growthEutopic endometrial cellsAbsence of leukocytesEndometriotic lesionsEndometrial cellsCell sortingPeritoneal cavityEmbryo implantationUterine endometriumEndometriosisEndometriumMesenchymal transitionLesionsGlobal gene expression profilingGene expression profilingUterusMigration of cellsMiceImmunofluorescenceQuantitative PCRFetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Aldad TS, Gan G, Gao XB, Taylor HS. Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice. Scientific Reports 2012, 2: 312. PMID: 22428084, PMCID: PMC3306017, DOI: 10.1038/srep00312.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsRadiofrequency radiation exposureLayer V pyramidal neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsRadiation exposureGlutamatergic synaptic transmissionExcitatory postsynaptic currentsLight/dark boxPatch-clamp recordingsNon-human primatesPyramidal neuronsRisk of exposurePostsynaptic currentsSynaptic transmissionCellular telephone useMouse modelClamp recordingsNeurobehavioral disordersDevelopmental programmingPrefrontal cortexMiceDark boxBehavioral changesNeurodevelopment
2011
Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming
Martin JR, Lieber SB, McGrath J, Shanabrough M, Horvath TL, Taylor HS. Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming. Endocrinology 2011, 152: 2060-2066. PMID: 21325042, PMCID: PMC3075930, DOI: 10.1210/en.2010-1485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationFemaleFertilityGene Expression Regulation, DevelopmentalGhrelinHeterozygoteHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryLitter SizeMaleMiceMice, KnockoutProliferating Cell Nuclear AntigenReproductionReverse Transcriptase Polymerase Chain ReactionTranscription FactorsUterusWnt ProteinsConceptsGhrelin deficiencyDevelopmental programmingAbnormal endometrial functionFemale wild-type miceUterus of miceLevels of ghrelinRegulation of appetiteWild-type miceReproductive tract developmentWild-type offspringSubsequent subfertilityEndometrial proliferationUnexposed miceEndometrial functionUtero exposureUterine expressionEmbryo implantationOvarian folliclesCorpora luteaGhrelinReproductive tractTract developmentMiceSignificant alterationsSubfertility
2010
Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro1
Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro1. Biology Of Reproduction 2010, 84: 106-112. PMID: 20844278, PMCID: PMC3012565, DOI: 10.1095/biolreprod.110.086744.Peer-Reviewed Original ResearchConceptsEffects of resveratrolEndometrial tissueEndometriotic implantsEndometrial implantsNude miceMatrigel invasionOophorectomized nude miceCell invasivenessAnti-inflammatory propertiesHuman endometrial tissueDevelopment of endometriosisCommon gynecologic disorderNude mouse modelConcentration-dependent reductionExperimental endometriosisGynecologic disordersIntraperitoneal injectionHealthy donorsTissue injectionMouse modelEndometriosisNovel treatmentsMiceInhibits developmentResveratrolIn Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice
2005
In vivo gene transfer of lefty leads to implantation failure in mice
Tang M, Taylor HS, Tabibzadeh S. In vivo gene transfer of lefty leads to implantation failure in mice. Human Reproduction 2005, 20: 1772-1778. PMID: 15790608, DOI: 10.1093/humrep/deh849.Peer-Reviewed Original ResearchConceptsVivo gene transferImplantation of blastocystsNumber of patientsNon-receptive phaseUnexplained infertilityImplantation failurePregnant miceKey cytokineMenstrual cycleHuman endometriumEndometriumReduced implantationReceptive phaseTissue remodellingGene transferImplantationInfertilityMiceUnique tissueOverexpressionVivo gene deliveryPotential factorsRetroviral vectorsInductionPatients
2003
Pleiotropic effects of Hoxa10 on the functional development of peri‐implantation endometrium
Daftary GS, Taylor HS. Pleiotropic effects of Hoxa10 on the functional development of peri‐implantation endometrium. Molecular Reproduction And Development 2003, 67: 8-14. PMID: 14648870, DOI: 10.1002/mrd.20013.Peer-Reviewed Original ResearchConceptsEndometrial receptivityOvariectomized miceEndometrial differentiationEndometrial HOXA10 expressionPeri-implantation endometriumHigh progesterone levelsAdditional control miceEosinophil infiltrationProgestational effectsUterine weightControl miceProgesterone treatmentProgesterone levelsEndometrial epitheliumOvarian progesteroneSpecific differentiation markersEmbryo implantationUterine endometriumHOXA10 expressionProgesteroneMiceEstrogenRegenerative adult tissuesFunctional differentiationVector pcDNA3.1
2000
Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation
Bagot CN, Troy PJ, Taylor HS. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Therapy 2000, 7: 1378-1384. PMID: 10981664, DOI: 10.1038/sj.gt.3301245.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernBlotting, WesternDNADNA-Binding ProteinsEmbryo ImplantationEndometriumFemaleGenes, HomeoboxGenetic TherapyHomeobox A10 ProteinsHomeodomain ProteinsHumansInfertility, FemaleLiposomesLitter SizeMiceMice, Inbred StrainsOligodeoxyribonucleotides, AntisensePregnancyTransfectionTumor Cells, CulturedConceptsHOXA10 expressionPotential contraceptive agentUterine factor infertilityHuman endometrial cell lineEndometrial cell lineTime of implantationFactor infertilityPregnant miceMaternal alterationsHuman endometriumContraceptive agentsEndometrial HOXA10Fertility treatmentImplantation sitesUterine environmentHOXA10 geneMiceImplanted embryosImplantationGene transfectionCell linesHOXA10DNA/liposome complexAlterationsAntisense oligodeoxyribonucleotide
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