2025
Quinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial
Pellicer A, Taylor H, Alberich-Bayarri A, Liu Y, Gamborg M, Barletta K, Pinton P, Heiser P, Bagger Y. Quinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2025, 310: 113946. PMID: 40188683, DOI: 10.1016/j.ejogrb.2025.113946.Peer-Reviewed Original ResearchConceptsDeep infiltrating endometriosisVaginal ringNo significant differenceLesion sizeBleeding patternsMenstrual cycleSignificant differenceImaging biomarkersSerum prolactin levelsPhase 2 trialMenstrual bleeding patternsEndpoint of reductionPatient-reported outcomesHigh-resolution MRIInfiltrating endometriosisPlacebo groupDouble-blindPlacebo-ControlledAdvanced diseaseEndometriotic lesionsPrimary endpointPain reductionSecondary endpointsProlactin levelsAdverse events
2019
Evaluation of miR-135a/b expression in endometriosis lesions
Petracco R, De Oliveira Dias A, Taylor H, Petracco Á, Badalotti M, Da Rosa Michelon J, Marinowic DR, Hentschke M, De Azevedo P, Zanirati G, Machado DC. Evaluation of miR-135a/b expression in endometriosis lesions. Biomedical Reports 2019, 11: 181-187. PMID: 31565224, PMCID: PMC6759580, DOI: 10.3892/br.2019.1237.Peer-Reviewed Original ResearchEndometriosis lesionsEndometrium tissuesSecretory phaseProliferative phaseExpression levelsReverse transcription‑quantitative polymerase chain reaction assaysEctopic endometriosis lesionsTranscription-quantitative polymerase chain reaction assaysPathogenesis of endometriosisEctopic endometrium tissuesEutopic endometrium tissuesPolymerase chain reaction assaysEndometrial functioningEndometrial receptivityMenstrual cycleChain reaction assaysLaparoscopic surgeryPost-transcriptional regulationEmbryo implantationQuantitative polymerase chain reaction assaysShort noncoding RNAsB expressionIncreased expressionExpression of genesLesionsEffects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study
Flores VA, Leone C, Taylor HS, Stachenfeld NS. Effects of bazedoxifene/conjugated estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study. Gynecological Endocrinology 2019, 35: 390-394. PMID: 30668182, DOI: 10.1080/09513590.2018.1559288.Peer-Reviewed Original ResearchConceptsBZA/CEPremenopausal womenConjugated estrogensReproductive hormonesUltrasonographic appearanceBazedoxifene/conjugated estrogensAbnormal ovarian folliculogenesisReproductive hormone changesCase series studyUnited States FoodEstrogen-receptor complexEndometrial alterationsDaily administrationSerum assessmentLH surgeMenopausal womenMenopausal symptomsMenstrual cycleClinical trialsEndocrinologic functionsOvarian morphologyHormone levelsPosttreatment valuesMurine modelOvarian folliculogenesis
2018
Therapeutic strategies involving uterine stem cells in reproductive medicine
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine. Current Opinion In Obstetrics & Gynecology 2018, 30: 209-216. PMID: 29652725, DOI: 10.1097/gco.0000000000000457.Peer-Reviewed Original ResearchConceptsStem cell mobilizationMultipotent stem cellsEndometrial defectAsherman's syndromeStem cellsStem cell biologyEndometrial receptivity defectsLow estrogen levelsBone marrow-derived multipotent stem cellsInjury-induced expressionUterine stem cellsEndometriosis therapyProgenitor stem cellsEndometrial diseaseEstrogen levelsNormal endometriumOverwhelming injuryStem cell recruitmentMenstrual cycleEndometrial cellsStem cell traffickingReservoir of cellsCell recruitmentChemokine CXCL12Therapeutic strategiesG-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis
Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS. G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reproductive Sciences 2018, 25: 1168-1174. PMID: 29587613, PMCID: PMC6346303, DOI: 10.1177/1933719118766256.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsNormal endometrial epitheliumChronic inflammatory diseaseOverexpression of CXCR7Chemokine ligand CXCL12Chemokine G-protein-coupled receptorsMurine endometriosisDifferent cellular populationsHuman endometriosisInflammatory diseasesMenstrual cycleChemokine receptorsReceptor CXCR7Endometrial epitheliumEndometriosis pathogenesisLigand CXCL12Murine modelMouse modelEndometriosisHigher stainingCXCR7Human findingsCell traffickingLow expressionNovel target
2017
Hormonal regulation of the endometrium and the effects of hormonal therapies
Ersoy G, Modi M, Alderman M, Taylor H. Hormonal regulation of the endometrium and the effects of hormonal therapies. 2017, 161-176. DOI: 10.1201/9781315151472-11.ChaptersSelective progesterone receptor modulatorsSelective estrogen receptor modulatorsMenopausal hormone therapyIntrauterine deviceOral contraceptivesMedroxyprogesterone acetateMenstrual cycleReceptor modulatorsGonadotropin-releasing hormone agonistProgesterone receptor modulatorsEstrogen receptor modulatorsHuman menstrual cycleHormonal regulationPractice of obstetricsHormonal therapyHormone therapyMenstrual bleedingEndometrial receptivityHormone agonistTestosterone signalingHormonal treatmentSecretory phaseEmbryo implantationEndometriumProliferative phase
2016
Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma
Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS. Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2883-2891. PMID: 27088794, PMCID: PMC4929835, DOI: 10.1210/jc.2016-1795.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAntigens, CDCarcinoma, EndometrioidCells, CulturedEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMenstrual CycleMiddle AgedProtein SubunitsReceptor, IGF Type 1Receptor, InsulinTranscriptomeConceptsIGF-1R expressionEndometrial hyperplasiaNormal endometriumEndometrial physiologySecretory phaseProliferative phaseIGF-1 receptor mRNAIR-B expressionNormal secretory phaseType 2 diabetesSex steroid treatmentEarly secretory phaseEarly proliferative phaseNormal proliferative phaseEndometrial proliferationEndometrioid adenocarcinomaComplex hyperplasiaEndometrial adenocarcinomaMass indexMenstrual cycleRisk factorsReceptor expressionIGF-1RMAIN OUTCOMEReceptor mRNA
2015
Circulating microRNAs as potential biomarkers for endometriosis
Cho S, Mutlu L, Grechukhina O, Taylor HS. Circulating microRNAs as potential biomarkers for endometriosis. Fertility And Sterility 2015, 103: 1252-1260.e1. PMID: 25772772, PMCID: PMC4417410, DOI: 10.1016/j.fertnstert.2015.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArea Under CurveCase-Control StudiesCell ProliferationEndometriosisFemaleGenetic MarkersHospitals, UniversityHumansLogistic ModelsMicroRNAsMiddle AgedPredictive Value of TestsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionROC CurveYoung AdultConceptsProliferative phaseLet-7bSerum CA-125 levelsMiR-135aCA-125 levelsSerum of womenBenign gynecologic diseaseCase-control studyQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionPotential noninvasive biomarkersLogistic regression modelsHighest areaGynecologic diseasePolymerase chain reactionUniversity HospitalMenstrual cycleEndometriosisMAIN OUTCOMENoninvasive biomarkersPotential biomarkersDiagnostic markerSerum samplesWomenChain reactionThe Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study
Zanatta A, Pereira RM, da Rocha A, Cogliati B, Baracat EC, Taylor HS, da Motta E, Serafini PC. The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study. Reproductive Sciences 2015, 22: 31-37. PMID: 25217304, PMCID: PMC4527422, DOI: 10.1177/1933719114549846.Peer-Reviewed Original ResearchConceptsProgesterone receptorRectosigmoid endometriosisEstrogen receptor αSecretory phaseReceptor αType of endometriosisExpression of ERExpression of HOXA10Tissue microarray blocksConsecutive patientsOvarian endometriosisOvarian lesionsEndometriotic lesionsDeep endometriosisMenstrual cycleAllred scoreExpression of proteinsHomeobox A10Deep diseaseEndometriosisMicroarray blocksSteroid receptorsPatientsReceptorsHOXA10
2012
Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium
Du H, Naqvi H, Taylor HS. Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium. Stem Cells And Development 2012, 21: 3324-3331. PMID: 22897736, PMCID: PMC3516416, DOI: 10.1089/scd.2011.0193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell MovementCell ProliferationEndometriumEstrous CycleFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLRegenerationReperfusion InjuryStem CellsUterusConceptsGranulocyte-colony stimulating factorSex steroidsMesenchymal stem cellsUterine repairUterine injuryBone marrowEstrous cycleIschemia/reperfusion injuryStem cellsBM-derived cellsG-CSF treatmentBM transplantsReperfusion injuryBM engraftmentIschemic injuryStem cell recruitmentMenstrual cycleMSC engraftmentCell recruitmentEndometriumInhibits migrationInjuryHematopoietic stem cellsStimulating factorUterusEndometrial Stem Cells.
Taylor H. Endometrial Stem Cells. Biology Of Reproduction 2012, 87: 32-32. DOI: 10.1093/biolreprod/87.s1.32.Peer-Reviewed Original ResearchProgenitor stem cellsMesenchymal stem cellsUterine injuryMenstrual cycleMultipotent stem cellsStem cellsAdult progenitor stem cellsPathogenesis of endometriosisEndometrial stem cellsMurine diabetes modelPancreatic beta cellsAsherman's syndromeEndometrial regenerationDopaminergic neuronsDiabetes modelRetrograde fashionMurine modelPeritoneal cavitySex steroidsParkinson's diseaseBeta cellsBone marrowEndometriosisRemarkable regenerative capacityEctopic locationsFKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012, 143: 531-538. PMID: 22279148, DOI: 10.1530/rep-11-0438.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsFKBP4 expressionFKBP5 expressionTreatment of hESCCultured human endometrial stromal cellsIGFBP1 expressionEndometrium of womenProtein levelsEndometrial stromal cellsLate proliferative phaseHOXA10 knockdownHOXA10 regulationImpaired decidualizationFertile womenEutopic endometriumMenstrual cycleSecretory phaseEndometriosisDecidualizationHOXA10 expressionProliferative phaseStromal cellsMRNA expressionFKBP5FKBP4
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometriumStem cells in endometrium and their role in the pathogenesis of endometriosis
Figueira PG, Abrão MS, Krikun G, Taylor H. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Annals Of The New York Academy Of Sciences 2011, 1221: 10-17. PMID: 21401624, PMCID: PMC3076708, DOI: 10.1111/j.1749-6632.2011.05969.x.Peer-Reviewed Original ResearchConceptsProgenitor stem cellsPathogenesis of endometriosisMesenchymal stem cellsMultipotent stem cellsStem cellsAdult progenitor stem cellsEndometrial stem cellsDopaminergic neuronsMenstrual cycleHuman endometriumRetrograde fashionMurine modelPeritoneal cavityParkinson's diseaseEndometriosisBone marrowRemarkable regenerative capacityEndometriumEctopic locationsRegenerative capacityPathogenesisDiseaseNeuronsDynamic tissueCellsHOX Genes and Endometriosis
Kulp J, Cakmak H, Taylor H. HOX Genes and Endometriosis. 2011, 184-189. DOI: 10.1002/9781444398519.ch18.Peer-Reviewed Original Research
2010
The Mechanism of Menstruation
Nair A, Taylor H. The Mechanism of Menstruation. Contemporary Endocrinology 2010, 21-34. DOI: 10.1007/978-1-60327-864-5_2.Peer-Reviewed Original ResearchHemochorial placentationDisorders of menstruationNormal endometrial physiologyAbnormal uterine bleedingReproductive-aged womenMaternal blood vesselsInfluence of progesteroneMechanisms of menstruationExtensive decidualizationUterine bleedingEndometrial physiologyProfound tissueTrophoblastic invasionBasalis layerMenstrual cycleMaternal bloodHormone supportFunctionalis layerMechanistic failureInvasive trophoblastTissue breakdownInvasive natureHemochorial placentaEndometriumChorionic villiHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10EpitheliumMenstrual cycle-related exacerbation of disease
Pinkerton JV, Guico-Pabia CJ, Taylor HS. Menstrual cycle-related exacerbation of disease. American Journal Of Obstetrics And Gynecology 2010, 202: 221-231. PMID: 20207238, PMCID: PMC3107848, DOI: 10.1016/j.ajog.2009.07.061.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderMenstrual cycleDysphoric disorderPerimenopausal depressionCommon mental health problemsPrimary care providersCommon psychiatric disordersMental health disordersMental health problemsAntidepressant agentsTreatment optionsDepressive disorderLuteal phaseRoutine screeningCare providersEffective treatmentPsychiatric disordersHealth disordersHealth problemsAccurate diagnosisNeuroendocrine systemPrecise causeDisordersExacerbationDepression
2009
Inflammation in Reproductive Disorders
Weiss G, Goldsmith LT, Taylor RN, Bellet D, Taylor HS. Inflammation in Reproductive Disorders. Reproductive Sciences 2009, 16: 216-229. PMID: 19208790, PMCID: PMC3107847, DOI: 10.1177/1933719108330087.Peer-Reviewed Original ResearchConceptsInflammatory disordersImmune responseReproductive-age womenNonspecific immune responsesImmune cell traffickingAnatomic disordersEndometrial developmentEndometrial functionEndometrial receptivityGynecologic diseaseInflammatory cytokinesAge womenImmune cellsMenstrual cycleInflammationTargeted treatmentReproductive disordersHormone productionCell traffickingInfectious diseasesNormal tissuesReproductive medicineDisordersTissue repairDisease
2008
Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells
Penna I, Du H, Ferriani R, Taylor HS. Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Human Reproduction 2008, 14: 613-618. PMID: 18829447, PMCID: PMC2734161, DOI: 10.1093/molehr/gan055.Peer-Reviewed Original ResearchConceptsEndometrial cellsGlandular cellsDevelopment of endometriosisHuman endometrial cellsExpression of HOXA10Real-time RT-PCRQuantitative real-time RT-PCRHOXA10 siRNAEndometrial biopsyEpithelial cell lineDecidual samplesEutopic endometriumMenstrual cyclePregnancy terminationEndometriosisFertile controlsHOXA10 expressionDecreased expressionRT-PCRProtein expressionRespective controlsHOXA10BiopsyCell linesAberrant regulation
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