2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical response
2017
Predictive Biomarkers May allow Precision Therapy of Endometriosis
Hou Z, Mamillapalli R, Taylor HS. Predictive Biomarkers May allow Precision Therapy of Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2017, 9: 279-285. PMID: 35441077, PMCID: PMC9014966, DOI: 10.5301/jeppd.5000311.Peer-Reviewed Original ResearchMedroxyprogesterone acetatePredictive biomarkersProgesterone receptorEstrogen receptorPrecision therapyEutopic endometrial stromal cellsSelective estrogen receptor modulatorsEffect of bazedoxifeneEndometrial stromal cellsEstrogen receptor modulatorsPathogenesis of endometriosisPrimary eutopic endometrial stromal cellsCommon molecular targetsPRA/BPersonalized medicine approachReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisBaseline expression levelsPelvic painEndometrial biopsyEndometriosis therapySevere endometriosisProgestin resistanceEndometriosis patientsPR expressionMedical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Sahin Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS. Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reproductive Sciences 2017, 24: 818-823. PMID: 28256937, DOI: 10.1177/1933719116682879.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMedroxyprogesterone acetateEstrogen deprivationEndometriosis lesionsStem cell recruitmentCell recruitmentLesions of endometriosisGreen fluorescent protein miceWeeks of treatmentBone marrow transplantLong-term treatmentMarrow-derived stem cellsStem cellsProgestin medroxyprogesterone acetateLong-term regressionBone marrow stem cellsStem cell engraftmentMarrow stem cellsProgestin therapyEndometriosis treatmentLesion regressionMedical therapyEndometriotic lesionsMarrow transplantC57BL/6 miceHormonal regulation of the endometrium and the effects of hormonal therapies
Ersoy G, Modi M, Alderman M, Taylor H. Hormonal regulation of the endometrium and the effects of hormonal therapies. 2017, 161-176. DOI: 10.1201/9781315151472-11.ChaptersSelective progesterone receptor modulatorsSelective estrogen receptor modulatorsMenopausal hormone therapyIntrauterine deviceOral contraceptivesMedroxyprogesterone acetateMenstrual cycleReceptor modulatorsGonadotropin-releasing hormone agonistProgesterone receptor modulatorsEstrogen receptor modulatorsHuman menstrual cycleHormonal regulationPractice of obstetricsHormonal therapyHormone therapyMenstrual bleedingEndometrial receptivityHormone agonistTestosterone signalingHormonal treatmentSecretory phaseEmbryo implantationEndometriumProliferative phase
2009
Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
Sarno J, Schatz F, Huang SJ, Lockwood C, Taylor HS. Thrombin and interleukin-1β decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss. Molecular Human Reproduction 2009, 15: 451-457. PMID: 19389728, PMCID: PMC2722817, DOI: 10.1093/molehr/gap030.Peer-Reviewed Original ResearchConceptsFirst trimester decidual cellsSpontaneous pregnancy lossPregnancy lossIL-1beta treatmentIL-1betaDecidual cellsMedroxyprogesterone acetateHuman first trimester decidual cellsFirst trimester deciduaProduction of cytokinesThrombin treatmentReal-time RT-PCRPregnancy outcomesSurgical treatmentViable pregnancyEarly pregnancySuccessful pregnancyElective terminationTrimester deciduaDefective implantationInflammation resultsInterleukin-1betaReal-time PCRThrombin generationAffymetrix microarray analysis
2007
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, Wu Y, Guo SW, Fazleabas AT. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Molecular Human Reproduction 2007, 13: 323-332. PMID: 17350963, DOI: 10.1093/molehr/gam005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBucladesineCells, CulturedDeciduaDNA MethylationEndometriosisEndometriumEpithelial CellsEstradiolFemaleGene Expression RegulationGene SilencingHomeobox A10 ProteinsHomeodomain ProteinsHumansInsulin-Like Growth Factor Binding Protein 1Medroxyprogesterone AcetatePapioPromoter Regions, GeneticRNA, MessengerStromal CellsTranscription FactorsConceptsHuman endometrial stromal cellsStromal cellsEutopic endometriumIGFBP1 mRNAIGFBP1 expressionInsulin-like growth factorMonths of diseaseEndometrial stromal cellsExpression of HOXA10Protein-1 mRNADisease-free animalsGynaecologic disordersHOXA10 levelsOverexpression of HOXA10Induced endometriosisMedroxyprogesterone acetateControl animalsEndometriosisHOXA10 mRNAHOXA10 expressionUterine environmentHOXA10 geneEndometriumGrowth factorAltered expression
2006
Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor
Sarno JL, Schatz F, Lockwood CJ, Huang S, Taylor HS. Thrombin and Interleukin-1β Regulate HOXA10 Expression in Human Term Decidual Cells: Implications for Preterm Labor. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 2366-2372. PMID: 16551735, DOI: 10.1210/jc.2005-1807.Peer-Reviewed Original ResearchConceptsTerm decidual cellsIL-1betaDecidual cellsProgesterone resistancePreterm laborHOXA10 mRNAHOXA10 expressionMedroxyprogesterone acetate treatmentProtein expressionHOXA10 protein expressionAcademic medical centerIntraamniotic infectionPreterm deliveryQuantitative RT-PCRProgestin resistanceMedroxyprogesterone acetateProgesterone withdrawalProinflammatory cytokinesMAIN OUTCOMEMedical CenterProgesterone responsivenessProstaglandin receptorsHuman parturitionAcetate treatmentAddition of thrombin
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