2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2019
CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMice
2018
Uterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceInsulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role
2017
Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X. Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis. Fertility And Sterility 2017, 108: 858-867.e2. PMID: 28923287, DOI: 10.1016/j.fertnstert.2017.08.018.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsProtein-coupled receptorsEutopic endometriumEpithelial markersHealthy egg donorsHuman eutopic endometriumType of endometriosisEndometrium of womenMenstrual cycle phaseProspective experimental studyParaffin-embedded tissuesEndometriotic patientsInflammatory markersEndometrial samplesUterine aspiratesHuman endometriumLeucine-rich repeatsFluorescence-activated cell sortingPathologic endometriumMAIN OUTCOMEEndometriosisReproductive outcomesEndometriumFertility clinicsStromal compartment
2015
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Seminars In Reproductive Medicine 2015, 33: 333-340. PMID: 26375413, PMCID: PMC4986990, DOI: 10.1055/s-0035-1564609.Peer-Reviewed Original ResearchConceptsStem cellsStem cell populationProgenitor stem cellsStem cell traffickingCyclic regenerationPool of cellsCell mobilityBone marrow-derived stem cellsMarrow-derived stem cellsDynamic organRecent characterizationUnrestrained growthCell populationsCell traffickingEctopic sitesCellsRapid regenerationHuman endometriumRegenerationPathologic roleGrowthEndometriosis interferesPathophysiology of endometriosisDevelopment of endometriosisTrafficking
2014
Endometrial Stem Cells as Potential Cures for Human Diseases
Krikun G, Taylor H. Endometrial Stem Cells as Potential Cures for Human Diseases. 2014, 39-43. DOI: 10.1007/978-1-4471-6542-2_5.Peer-Reviewed Original ResearchAdult stem cellsImmediate therapeutic applicationStem cellsMultipotent mesenchymal stem cellsTeratoma formationGenetic transformationMesenchymal stem cellsBeta-like cellsTherapeutic applicationsEndometrial stem cellsMedical potentialSpecific culture techniquesDifferentiated cell typesEngenders optimismClinical applicationTissue repairPancreatic beta-like cellsHuman endometriumReliable therapyApplicationsPotential cureCatastrophic illnessUndifferentiated cellsCulture techniquesPreliminary dataHOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling
Kallen AN, Haines K, Taylor HS. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. Reproductive Sciences 2014, 21: 892-897. PMID: 24532216, PMCID: PMC4107567, DOI: 10.1177/1933719113519168.Peer-Reviewed Original ResearchDynamic intracellular networkExpression levelsProtein expressionCell linesMammalian cytoskeletonEndometrial epithelial cell lineCytoskeletal remodelingEpithelial cell lineIntracellular networksGene expressionCytoskeletal changesQuantitative real-time polymerase chain reactionRegulate expressionHuman endometrial epithelial cell lineMessenger RNACytokeratin 15Cellular architectureKeratin filamentsEpithelial remodelingExpression decreasesTotal RNAHuman endometrial epithelial cellsHuman endometriumReal-time polymerase chain reactionEpithelial cells
2012
Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertility And Sterility 2012, 98: 948-956.e1. PMID: 22789143, PMCID: PMC3462249, DOI: 10.1016/j.fertnstert.2012.06.009.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEndometrial tissueStromal cellsCannabinoid receptor type 1 expressionProgesterone-dominated secretory phaseMRNA expressionAnti-inflammatory actionMessenger RNATetrachlorodibenzo-p-dioxin (TCDD) exposureHuman endometrial tissueProgesterone receptor antagonistType 1 expressionSteroid-induced expressionProgesterone-dependent regulationEndometrial biopsyReceptor antagonistCannabinoid signalingHuman endometriumMedical CenterMAIN OUTCOMESecretory phaseControl donorsEndometriosisDifferentiation-related expressionExposure disrupts
2011
Stem cells in endometrium and their role in the pathogenesis of endometriosis
Figueira PG, Abrão MS, Krikun G, Taylor H. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Annals Of The New York Academy Of Sciences 2011, 1221: 10-17. PMID: 21401624, PMCID: PMC3076708, DOI: 10.1111/j.1749-6632.2011.05969.x.Peer-Reviewed Original ResearchConceptsProgenitor stem cellsPathogenesis of endometriosisMesenchymal stem cellsMultipotent stem cellsStem cellsAdult progenitor stem cellsEndometrial stem cellsDopaminergic neuronsMenstrual cycleHuman endometriumRetrograde fashionMurine modelPeritoneal cavityParkinson's diseaseEndometriosisBone marrowRemarkable regenerative capacityEndometriumEctopic locationsRegenerative capacityPathogenesisDiseaseNeuronsDynamic tissueCellsCigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1
Zhou Y, Jorgensen EM, Gan Y, Taylor HS. Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1. Biology Of Reproduction 2011, 84: 1242-1247. PMID: 21325691, PMCID: PMC3099588, DOI: 10.1095/biolreprod.110.087494.Peer-Reviewed Original ResearchConceptsProgesterone receptorCigarette smokeRate of endometriosisEffect of smokingCigarette smoke extractEndometrial stromal cellsExpression of HOXA10Poor health outcomesEndometrial cancerEndometrial pathologyEndometrial diseaseCigarette smokingDecreased incidenceOvarian alterationsDecreased prevalenceEndometrial tumorsEndometrial differentiationEndometrial cellsHuman endometriumSmoke extractProtective effectHomeobox A10Health outcomesHomeobox A10 expressionSmoking
2010
HOXA10 regulates endometrial GABAA π receptor expression and membrane translocation
Sadeghi H, Taylor HS. HOXA10 regulates endometrial GABAA π receptor expression and membrane translocation. AJP Endocrinology And Metabolism 2010, 298: e889-e893. PMID: 20103740, PMCID: PMC3774337, DOI: 10.1152/ajpendo.00577.2009.Peer-Reviewed Original ResearchConceptsReceptor mRNA expressionHuman endometriumHOXA10 expressionHOXA10 siRNAMRNA expressionReceptor expressionHuman endometrial adenocarcinoma cell line IshikawaEndometrial adenocarcinoma cell line IshikawaCoadministration of progesteroneLuteal phase progesteroneGABA receptor subtypesProgesterone-responsive genesGABA receptor activityReal-time RT-PCRReceptor ion channelsEndometrial receptivityProgesterone treatmentImplantation windowReceptor subtypesProgesterone regulationGABA receptorsReceptor mRNAEmbryo implantationLuminal epitheliumEndometriumMolecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions
Cakmak H, Taylor H. Molecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions. Seminars In Reproductive Medicine 2010, 28: 069-074. PMID: 20104430, PMCID: PMC3107856, DOI: 10.1055/s-0029-1242996.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionEndometriosis-related infertilityEndometrium of womenExpression of HOXA10Progesterone-responsive genesTime of implantationProgesterone target genesHOXA10 gene expressionEndometrial growthIGFBP-1Progesterone resistanceEndometrial receptivityProgesterone responseEutopic endometriumHuman endometriumProgesterone levelsReceptor expressionTreatment resistanceSex steroidsEndometriosisEndometriumDiminished activityAlphavbeta3 integrinHOXA10Women
2007
Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis
Wolff EF, Wolff AB, Du H, Taylor HS. Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis. Reproductive Sciences 2007, 14: 524-533. PMID: 17959881, DOI: 10.1177/1933719107306896.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsMultipotent stem cellsFallopian tubeType II collagenStem cellsReproductive-aged womenHuman articular cartilageEndometrial stem cellsAdult human endometriumII collagenMultilineage differentiationArticular cartilageBenign diseaseEndometrial tissueExtramedullary tissuesHuman endometriumCell pelletsEndometriumChondrogenic mediumStromal cellsLigament cellsSulfated glycosaminoglycansGrowth factorProgenitor cellsCell types
2005
In vivo gene transfer of lefty leads to implantation failure in mice
Tang M, Taylor HS, Tabibzadeh S. In vivo gene transfer of lefty leads to implantation failure in mice. Human Reproduction 2005, 20: 1772-1778. PMID: 15790608, DOI: 10.1093/humrep/deh849.Peer-Reviewed Original ResearchConceptsVivo gene transferImplantation of blastocystsNumber of patientsNon-receptive phaseUnexplained infertilityImplantation failurePregnant miceKey cytokineMenstrual cycleHuman endometriumEndometriumReduced implantationReceptive phaseTissue remodellingGene transferImplantationInfertilityMiceUnique tissueOverexpressionVivo gene deliveryPotential factorsRetroviral vectorsInductionPatients
2004
HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes
Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 522-528. PMID: 15494461, DOI: 10.1210/jc.2004-0817.Peer-Reviewed Original ResearchConceptsTarget gene specificityGene specificityHoxA10 target geneMultimeric complexesTranscription factorsTarget genesTrimeric complexHOXA10 regulationEMX2 geneMeis1Myeloid differentiationPBX2 expressionDimer bindingProtein expressionBinding sitesHOXA10Cycle stagesGenesObserved expressionPBX2ExpressionCofactorBindingEmbryonic uterine developmentHuman endometrium
2003
HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1
Akbas GE, Taylor HS. HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1. Biology Of Reproduction 2003, 70: 39-45. PMID: 12954737, DOI: 10.1095/biolreprod.102.014969.Peer-Reviewed Original ResearchConceptsEndometrial developmentExpression of HOXC10Secretory phasePrimary endometrial stromal cellsSemiquantitative reverse transcription-polymerase chain reactionEndometrial stromal cellsReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionEndometrial proliferationEndometrial receptivityEndometrial differentiationMenstrual cycleHuman endometriumIshikawa cellsSex steroidsDecreased expressionStromal cellsChain reactionEndometriumHOXA genesHOXA10HOXD10Distinct expression patternsSitu hybridizationHOXC10
2001
HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1
Cermik D, Karaca M, Taylor H. HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 3387-3392. PMID: 11443215, DOI: 10.1210/jcem.86.7.7675.Peer-Reviewed Original ResearchConceptsHox gene expressionHOXA10 expressionHox genesDifferential tissue-specific regulationHigh serum progesterone levelsGene expressionPrimary myometrial cell culturesSerum progesterone levelsDevelopmental regulatory genesAdult human endometriumDifferential HOX gene expressionSteroid receptor coactivatorTissue-specific regulationTissue-specific responsesMyometrial cell culturesEndometrial developmentProgesterone receptorMenstrual cycleHuman endometriumMulticellular organismsNonpregnant uterusProgesterone levelsSex steroidsMidsecretory phaseMyometrium
2000
Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation
Bagot CN, Troy PJ, Taylor HS. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Therapy 2000, 7: 1378-1384. PMID: 10981664, DOI: 10.1038/sj.gt.3301245.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernBlotting, WesternDNADNA-Binding ProteinsEmbryo ImplantationEndometriumFemaleGenes, HomeoboxGenetic TherapyHomeobox A10 ProteinsHomeodomain ProteinsHumansInfertility, FemaleLiposomesLitter SizeMiceMice, Inbred StrainsOligodeoxyribonucleotides, AntisensePregnancyTransfectionTumor Cells, CulturedConceptsHOXA10 expressionPotential contraceptive agentUterine factor infertilityHuman endometrial cell lineEndometrial cell lineTime of implantationFactor infertilityPregnant miceMaternal alterationsHuman endometriumContraceptive agentsEndometrial HOXA10Fertility treatmentImplantation sitesUterine environmentHOXA10 geneMiceImplanted embryosImplantationGene transfectionCell linesHOXA10DNA/liposome complexAlterationsAntisense oligodeoxyribonucleotide
1999
Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
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