2025
Gonadotropin-releasing hormone antagonists: a prompt to early use in the hormonal treatment of gynecologic disease
Taylor H. Gonadotropin-releasing hormone antagonists: a prompt to early use in the hormonal treatment of gynecologic disease. Fertility And Sterility 2025, 123: 1012-1013. PMID: 40164377, DOI: 10.1016/j.fertnstert.2025.03.025.Peer-Reviewed Original Research
2022
O-163 Pathophysiology – what’s new
Taylor H. O-163 Pathophysiology – what’s new. Human Reproduction 2022, 37: deac105.073. DOI: 10.1093/humrep/deac105.073.Peer-Reviewed Original ResearchSystemic diseaseGynecological diseasesOral gonadotropin-releasing hormone antagonistClinical diagnosisLow-dose oral contraceptivesGonadotropin-releasing hormone antagonistEndometrial-like tissueFirst-line medicationAccurate clinical diagnosisFemale reproductive tractOral contraceptivesPrompt treatmentSystemic inflammationGnRH antagonistPain sensitizationProgesterone resistanceSymptomatic womenClinical presentationRetrograde menstruationEndometriosis careHormone antagonistReproductive ageEffective therapyTherapeutic alternativeMood disorders
2021
Activation of Hypocretin Neurons in Endometriosis
Mamillapalli R, Dang T, Habata S, Gao XB, Taylor HS. Activation of Hypocretin Neurons in Endometriosis. Reproductive Sciences 2021, 29: 243-249. PMID: 34279849, DOI: 10.1007/s43032-021-00682-4.Peer-Reviewed Original ResearchConceptsBody mass indexCAMP-responsive element binding proteinBody weightLower body mass indexNeuronal systemsHypocretin/orexin neuronsBehavioral changesPrevious murine studiesHigh-fat dietExpression of phosphorylationOrexin activitySham miceOrexin neuronsPain sensitizationGynecologic symptomsHypocretin neuronsMass indexHcrt cellsEndometriosis miceFat dietLateral hypothalamusPain perceptionReproductive ageGynecological diseasesMurine studies
2019
Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model
Rosa-e-Silva ACJS, Rosa-e-Silva JC, Mamillapalli R, Taylor HS. Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model. Reproductive Sciences 2019, 26: 1395-1400. PMID: 31274059, PMCID: PMC6949971, DOI: 10.1177/1933719119859438.Peer-Reviewed Original ResearchConceptsMurine modelCurrent clinical staging systemBurden of endometriosisClinical staging systemClear dose-response relationshipDegree of painStage of diseaseEffect of endometriosisMechanism of infertilityGroups of miceSequelae of diseaseSeverity of symptomsDose-response relationshipSham surgery controlsActive diseaseDisease activityPelvic painStaging systemEarly recognitionEctopic tissueEndometrial cellsGynecological diseasesSurgery controlsPregnancy rateUterine tissue
2015
Integrative Analysis Reveals Regulatory Programs in Endometriosis
Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS. Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reproductive Sciences 2015, 22: 1060-1072. PMID: 26134036, PMCID: PMC5933170, DOI: 10.1177/1933719115592709.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationComputational BiologyCore Binding Factor Alpha 2 SubunitDatabases, GeneticEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic MarkersHepatocyte Nuclear Factor 3-betaHumansProtein BindingProtein Interaction MappingProtein Interaction MapsReceptors, AndrogenTranscription Factor AP-2Transcription, GeneticTumor Suppressor Protein p53ConceptsAndrogen receptorFunction of ARReproductive-age womenCommon gynecological diseasePathology of endometriosisEstrogen receptor βEstrogen receptor αReal-time polymerase chain reactionSuch expression changesQuantitative real-time polymerase chain reactionPolymerase chain reactionGynecological diseasesGene expressionGene Expression Omnibus databaseEndometriosisReceptor βReceptor αTranscription factors
2014
MicroRNA and gynecological reproductive diseases
Santamaria X, Taylor H. MicroRNA and gynecological reproductive diseases. Fertility And Sterility 2014, 101: 1545-1551. PMID: 24882618, DOI: 10.1016/j.fertnstert.2014.04.044.Peer-Reviewed Original ResearchConceptsSmall non-coding RNAsTranslation of mRNAsNon-coding RNAsAberrant miRNA expressionHuman diseasesMiRNA expressionAbnormal expressionMicroRNAsReproductive tract diseaseReproductive diseasesExpressionGenesMiRNAsMiRNARNATranslationMRNATherapeutic toolDysregulationGynecological diseasesInflammatory diseases
2010
Implantation failure: molecular mechanisms and clinical treatment
Cakmak H, Taylor HS. Implantation failure: molecular mechanisms and clinical treatment. Human Reproduction Update 2010, 17: 242-253. PMID: 20729534, PMCID: PMC3039220, DOI: 10.1093/humupd/dmq037.Peer-Reviewed Original ResearchConceptsGynecological diseasesEndometrial receptivityImplantation rateImplantation failureOptimal current therapyPolycystic ovarian syndromeStem cell-based therapiesSynchronized dialogueOvarian syndromePregnancy outcomesCell-based therapiesImplantation markersSuccessful pregnancySurgical interventionCurrent therapiesEndometrial cellsUterine receptivityAbnormal cytokineAnimal modelsEndometrial genesClinical treatmentEmbryo qualityFertility treatmentExact mechanismDisease
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