2025
Effect of endometriosis-linked microRNAs on hepatic gene expression
Mamillapalli R, Slutzky R, Mangla A, Gawde N, Taylor H. Effect of endometriosis-linked microRNAs on hepatic gene expression. F&S Science 2025, 6: 221-231. PMID: 39971156, DOI: 10.1016/j.xfss.2025.02.001.Peer-Reviewed Original ResearchMiR-3613-5pMiR-let-7bMiR-125b-5pMiR-150MiR-150-5pCirculating microRNAsMicroRNAsReactionExpression of IGFBP1Quantitative polymerase chain reactionSuppress target genesExpression of MRC1Polymerase chain reactionBinding sitesReal-time quantitative polymerase chain reactionHepatic gene expressionExpression of CYP2R1Bioinformatics analysisEffect of endometriosisSerum of womenCirculation of womenGene expressionChain reactionMiRsHepatic cells
2024
High NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish
Seli D, Prendergast A, Ergun Y, Tyagi A, Taylor H. High NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish. International Journal Of Molecular Sciences 2024, 25: 4104. PMID: 38612913, PMCID: PMC11012806, DOI: 10.3390/ijms25074104.Peer-Reviewed Original ResearchConceptsNaCl concentrationGene expressionIncreasing NaCl concentrationATM signaling pathwayUninflated swim bladderSwim bladder developmentHigh NaCl concentrationsEmbryo growthAssociated with developmental abnormalitiesSwim bladderLarval stageEarly embryo growthEmbryonic deathDevelopmental abnormalitiesSignaling pathwayDevelopment of zebrafishGenes SHHCalcium chlorideGenesSodium chlorideE3 mediumStages of developmentZebrafish embryosAffected ecosystemsPotassium chloride
2021
Molecular mechanisms of estrogen action in female genital tract development
Alderman MH, Taylor HS. Molecular mechanisms of estrogen action in female genital tract development. Differentiation 2021, 118: 34-40. PMID: 33707128, PMCID: PMC8073215, DOI: 10.1016/j.diff.2021.01.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expressionSelective estrogen receptor modulatorsFemale genital tract developmentAberrant CpG methylationGenital tract developmentHistone modificationsEpigenetic regulationOrgan developmentCpG methylationTranscriptional pathwaysSpecific fetalEpigenetic modulationMolecular mechanismsFemale reproductive tractLate organogenesisHormonal regulationOrganogenesisEstrogen receptor modulatorsTract developmentReproductive tractIndependent fashionRegulationDisease statesEstrogen actionReceptor modulators
2019
Endometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Family Medicine 2019 DOI: 10.2310/fm.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiologyEndometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Medicine 2019 DOI: 10.2310/im.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiology
2018
Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†
Li T, Mamillapalli R, Ding S, Chang H, Liu ZW, Gao XB, Taylor HS. Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†. Biology Of Reproduction 2018, 99: 349-359. PMID: 29425272, PMCID: PMC6692844, DOI: 10.1093/biolre/ioy035.Peer-Reviewed Original ResearchConceptsEffect of endometriosisPain sensitizationPain perceptionBrain electrophysiologyEstrogen-dependent inflammatory disorderReproductive-aged womenDetection of endometriosisRegions of brainPatch-clamp recordingsCentral sensitizationPelvic painGene expressionInflammatory disordersEndometriosis miceFemale miceSham controlsMood disordersEndometriosisPainClamp recordingsBehavioral testsMiceBrain gene expressionSensitizationElectrophysiology
2017
Endometriosis alters anxiety, depression and pain perception as well as brain electrophysiology and gene expression in mice
Mamillapalli R, Gao X, Taylor H. Endometriosis alters anxiety, depression and pain perception as well as brain electrophysiology and gene expression in mice. Fertility And Sterility 2017, 108: e43-e44. DOI: 10.1016/j.fertnstert.2017.07.142.Peer-Reviewed Original ResearchBisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression
Ilagan Y, Mamillapalli R, Goetz L, Kayani J, Taylor HS. Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression. Reproductive Toxicology 2017, 71: 84-94. PMID: 28476547, DOI: 10.1016/j.reprotox.2017.05.001.Peer-Reviewed Original ResearchConceptsBPA exposureGene expressionAdult gene expressionFetal BPA exposureBisphenol A (BPA) exposureMetabolic gene expressionEstrogen receptor alphaExpression of genesBeta gene expressionEstrogenic stateEstrogen treatmentPregnant miceMetabolic disordersE2 stimulationReceptor alphaFetal developmentLipid metabolismDay 9Developmental programmingSexual dimorphismFemale offspringLiverObesityGenesAdult responses
2016
Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1
Goetz L, Mamillapalli R, Taylor HS. Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1. Biology Of Reproduction 2016, 95: 115, 1-8. PMID: 27628219, PMCID: PMC5315422, DOI: 10.1095/biolreprod.116.142877.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody Mass IndexBody WeightCholestanetriol 26-MonooxygenaseDisease Models, AnimalDown-RegulationEndometriosisEndometriumFatty Acid-Binding ProteinsFemaleGene Expression ProfilingInsulin-Like Growth Factor Binding Protein 1LiverMembrane GlycoproteinsMicePeritoneal DiseasesReceptors, Cell SurfaceReceptors, Immunologicrho-Associated KinasesUp-RegulationConceptsLower body mass indexBody mass indexMass indexBody fatBody weightDual-energy X-ray absorptiometry scanningLower total body fatEffect of endometriosisTotal body fatLower body weightLiver of miceExpression levelsHepatic gene expressionLiver gene expressionMultiorgan natureMouse endometriumEndometrial cellsFemale miceGene expressionPeritoneal cavityEndometriosisDisease endometriosisMiceWeight lossKey metabolic genesPreferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant doseEndometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2015
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harbor Perspectives In Medicine 2015, 6: a023002. PMID: 26552702, PMCID: PMC4691806, DOI: 10.1101/cshperspect.a023002.Peer-Reviewed Original ResearchConceptsReproductive tract developmentEndometrial developmentTract developmentPolycystic ovarian syndromeFemale reproductive tract developmentFemale reproductive trackOvarian syndromeEndometrial receptivityImplantation rateFemale infertilityGene expressionMüllerian defectsHOXA11 expressionGene mutationsReproductive trackAdult functionDevelopmental abnormalitiesHOXA10AbnormalitiesEndocrine disruptorsDiethylstilbestrolImplantationEssential regulatorExpressionIntegrative Analysis Reveals Regulatory Programs in Endometriosis
Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS. Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reproductive Sciences 2015, 22: 1060-1072. PMID: 26134036, PMCID: PMC5933170, DOI: 10.1177/1933719115592709.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationComputational BiologyCore Binding Factor Alpha 2 SubunitDatabases, GeneticEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic MarkersHepatocyte Nuclear Factor 3-betaHumansProtein BindingProtein Interaction MappingProtein Interaction MapsReceptors, AndrogenTranscription Factor AP-2Transcription, GeneticTumor Suppressor Protein p53ConceptsAndrogen receptorFunction of ARReproductive-age womenCommon gynecological diseasePathology of endometriosisEstrogen receptor βEstrogen receptor αReal-time polymerase chain reactionSuch expression changesQuantitative real-time polymerase chain reactionPolymerase chain reactionGynecological diseasesGene expressionGene Expression Omnibus databaseEndometriosisReceptor βReceptor αTranscription factors
2014
Altered Genome-Wide Methylation in Endometriosis
Naqvi H, Ilagan Y, Krikun G, Taylor HS. Altered Genome-Wide Methylation in Endometriosis. Reproductive Sciences 2014, 21: 1237-1243. PMID: 24784717, PMCID: PMC5933183, DOI: 10.1177/1933719114532841.Peer-Reviewed Original ResearchConceptsGene expressionBone morphogenetic protein receptorGenome-wide methylationDual specificity phosphatase 22Morphogenetic protein receptorTumor protein 73Genome-wide methylation arrayAberrant DNA methylationInhibitor of DNADNA methylationCandidate genesBinding protein 7Member 21Methylation arraysProtein receptorsQuantitative real-time polymerase chain reactionGenesImmunoglobulin SuperfamilyAberrant methylationMethylation statusProtein 7MethylationCell proliferationAbnormal regulationReceptor 1BHOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling
Kallen AN, Haines K, Taylor HS. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. Reproductive Sciences 2014, 21: 892-897. PMID: 24532216, PMCID: PMC4107567, DOI: 10.1177/1933719113519168.Peer-Reviewed Original ResearchDynamic intracellular networkExpression levelsProtein expressionCell linesMammalian cytoskeletonEndometrial epithelial cell lineCytoskeletal remodelingEpithelial cell lineIntracellular networksGene expressionCytoskeletal changesQuantitative real-time polymerase chain reactionRegulate expressionHuman endometrial epithelial cell lineMessenger RNACytokeratin 15Cellular architectureKeratin filamentsEpithelial remodelingExpression decreasesTotal RNAHuman endometrial epithelial cellsHuman endometriumReal-time polymerase chain reactionEpithelial cells
2010
HOXA10 expression is decreased in endometrium of women with adenomyosis
Fischer CP, Kayisili U, Taylor HS. HOXA10 expression is decreased in endometrium of women with adenomyosis. Fertility And Sterility 2010, 95: 1133-1136. PMID: 21067721, PMCID: PMC3053130, DOI: 10.1016/j.fertnstert.2010.09.060.Peer-Reviewed Original ResearchBisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
Bromer JG, Zhou Y, Taylor MB, Doherty L, Taylor HS. Bisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. The FASEB Journal 2010, 24: 2273-2280. PMID: 20181937, PMCID: PMC3230522, DOI: 10.1096/fj.09-140533.Peer-Reviewed Original ResearchConceptsEpigenetic alterationsCytosine-guanine dinucleotides (CpGs) methylationUtero BPA exposureHomeobox gene HOXA10Developmental programmingDiminished methylationChromatin immunoprecipitationBisulfite sequencingEpigenetic mechanismsDNA methylationPromoter sequencesBPA exposureMethylation profilesExpression patternsGene expressionUterine organogenesisUterine estrogen responsesMethylationNovel mechanismGeneral mechanismPregnant CD-1 miceProtein expressionCD-1 miceHOXA10Expression
2009
WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
Andikyan V, Taylor HS. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. Journal Of Cellular And Molecular Medicine 2009, 13: 4522-4531. PMID: 19017365, PMCID: PMC3107857, DOI: 10.1111/j.1582-4934.2008.00574.x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEndometrial NeoplasmsEndometriumEnhancer Elements, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenital Neoplasms, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansKidneyMullerian DuctsOvarian NeoplasmsPromoter Regions, GeneticProtein BindingRepressor ProteinsUterine Cervical NeoplasmsWT1 ProteinsConceptsHox gene expressionGene expressionHomeobox gene HOXA10HOXA10 expressionEpithelial cell typesHox genesTumor 1 geneRepressor activityHomeobox genesEpithelial enhancersTranscription factorsEmbryonic developmentRegulatory elementsExpression of WT1Enhancer activitySelective repressionRepressor elementAberrant regulationDevelopmental identityOvarian cancer cellsUterine organogenesisCell typesGenesRepressorCancer cells
2008
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
Lee B, Du H, Taylor HS. Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1. Biology Of Reproduction 2008, 80: 79-85. PMID: 18799756, PMCID: PMC2804809, DOI: 10.1095/biolreprod.108.070391.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEndometriosisEndometriumFemaleGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryInsulin-Like Growth Factor Binding Protein 1Integrin beta ChainsKruppel-Like Transcription FactorsMiceReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndometriosis groupEndometrial receptivityEutopic endometriumExperimental endometriosisAltered gene expressionInsulin-like growth factorInduction of endometriosisKruppel-like factor 9Expression of HOXA10Total progesterone receptorEndometrial gene expressionBeta3 mRNA expressionProtein-1 mRNAReal-time RT-PCRQuantitative real-time RT-PCRGene expressionMurine endometriosisNormal endometriumProgesterone receptorMethylation-specific PCREndometriosisEndometriumMRNA expressionEctopic locationsGrowth factorEndocrine Disruptors Alter HOX Gene Expression in the Reproductive Tract.
Taylor H. Endocrine Disruptors Alter HOX Gene Expression in the Reproductive Tract. Biology Of Reproduction 2008, 78: 232-233. DOI: 10.1093/biolreprod/78.s1.232b.Peer-Reviewed Original ResearchHox gene expressionEssential developmental genesHox genesGene expressionEstrogen response elementHOXA10 estrogen response elementDevelopmental genesPositional identityDevelopmental identityDevelopmental programmingMolecular mechanismsFemale reproductive tractParticular Hox genesReproductive tractHox codeMüllerian ductsAxial identityDevelopment genesEstrogen-responsive genesSegment identityExpression domainsReproductive successResponsive genesTranscription factorsNormal patterning
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