2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cells
2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2019
Bone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus
Tal R, Dong D, Shaikh S, Mamillapalli R, Taylor HS. Bone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus. Biology Of Reproduction 2019, 100: 1228-1237. PMID: 30601943, PMCID: PMC6497522, DOI: 10.1093/biolre/ioy265.Peer-Reviewed Original ResearchConceptsEndothelial progenitor cellsPregnant uterusImplantation sitesPregnant miceBM-derived endothelial progenitor cellsProgenitor cellsEarly pregnant uterusUterine implantation sitesContribution of BMNew blood vesselsEndometrial growthBM transplantationEndothelial cell populationEndometrial vasculaturePregnancy maintenanceDecidual vasculatureMouse recipientsGestational dayVascular endotheliumEndothelial-specific promoterBone marrowTransgenic miceMouse deciduaFlow cytometryMice
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