2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2021
Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression
Kotlyar AM, Mamillapalli R, Flores VA, Taylor HS. Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression. Molecular Human Reproduction 2021, 27: gaab016. PMID: 33693775, PMCID: PMC8454207, DOI: 10.1093/molehr/gaab016.Peer-Reviewed Original ResearchConceptsLesion regressionIshikawa cellsJAK/STATGrowth factor mRNA levelsEffects of tofacitinibTreatment of endometriosisHypoxia-inducible factor-1αVascular endothelial growth factor (VEGF) mRNA levelsFactor mRNA levelsWidespread clinical useWestern blot analysisVehicle treatmentOral gavageGynecologic conditionsC57BL/6 miceEutopic endometriumJanus kinase/signal transducerReproductive ageEndometriosisJAK inhibitorsKinase/signal transducerTofacitinibTherapeutic targetLesion growthClinical use
2020
Endometriosis: The Role of Iron Overload and Ferroptosis
Ng SW, Norwitz SG, Taylor HS, Norwitz ER. Endometriosis: The Role of Iron Overload and Ferroptosis. Reproductive Sciences 2020, 27: 1383-1390. PMID: 32077077, DOI: 10.1007/s43032-020-00164-z.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsIron overloadRetrograde menstruationEndometrial tissueSubsequent pathophysiologyEutopic endometriumRisk factorsAbdominal cavityWomen's healthReproductive disordersIron deficiencyEndometriosisSuch disordersLesionsIron excessPrimary defectEctopic sitesCholesterol biosynthetic pathwayNon-apoptotic programmed cell deathCell survivalCell deathIron homeostasisDisordersFerroptosisOverloadCXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, Taylor HS. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. Journal Of Cellular And Molecular Medicine 2020, 24: 2464-2474. PMID: 31904910, PMCID: PMC7028867, DOI: 10.1111/jcmm.14933.Peer-Reviewed Original ResearchConceptsCXCR7 antagonistLesion sizePro-inflammatory cytokine productionBone marrow-derived cellsNon-hormonal therapiesMouse bone marrow transplantation modelBone marrow transplantation modelBone marrow cell migrationMarrow-derived cellsProgression of endometriosisEndometriosis implantsEndometrial effectsAntagonist treatmentEndometriotic lesionsCytokine productionEndometrial physiologyStem cell recruitmentEutopic endometriumTransplantation modelCell recruitmentNull miceCell traffickingEndometriosisEpithelial cell fateCXCR4
2019
Potential roles of aquaporin 9 in the pathogenesis of endometriosis
Choi YS, Park JH, Yoon JK, Yoon JS, Kim JS, Lee JH, Yun BH, Park JH, Seo SK, Cho S, Lee BS, Taylor HS. Potential roles of aquaporin 9 in the pathogenesis of endometriosis. Molecular Human Reproduction 2019, 25: 373-384. PMID: 31070762, DOI: 10.1093/molehr/gaz025.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsPathogenesis of endometriosisEndometrial stromal cellsPotential therapeutic targetExpression of MMP2P38 MAPK proteinWestern blot analysisControl patientsEndometrial expressionPhosphorylated ERK 1/2Ectopic endometriumEutopic endometriumInflammatory processLaparoscopic surgeryEndometriosisTherapeutic targetBenign conditionsAQP subtypesExpression of AQP9Stromal cellsTumor developmentWestern blottingAQP9 expressionHealing assaysERK 1/2
2017
Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X. Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis. Fertility And Sterility 2017, 108: 858-867.e2. PMID: 28923287, DOI: 10.1016/j.fertnstert.2017.08.018.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsProtein-coupled receptorsEutopic endometriumEpithelial markersHealthy egg donorsHuman eutopic endometriumType of endometriosisEndometrium of womenMenstrual cycle phaseProspective experimental studyParaffin-embedded tissuesEndometriotic patientsInflammatory markersEndometrial samplesUterine aspiratesHuman endometriumLeucine-rich repeatsFluorescence-activated cell sortingPathologic endometriumMAIN OUTCOMEEndometriosisReproductive outcomesEndometriumFertility clinicsStromal compartmentEffect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alphaBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS. Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reproductive Sciences 2017, 24: 526-533. PMID: 27729562, PMCID: PMC5933203, DOI: 10.1177/1933719116672587.Peer-Reviewed Original ResearchConceptsEutopic endometriumEndometriotic lesionsChemotactic activityCXCR4 messenger RNAProtein expressionTreatment of endometriosisCXCR4 protein expressionStem cellsExpression of CXCL12CXCL12/CXCR4Transwell chamber migrationCXCL12 protein expressionEnzyme-linked immunosorbentBone marrow stem cellsBone marrow cellsMouse bone marrow stem cellsMarrow stem cellsEndometrial tissueControl endometriumGynecological disordersEndometriosisEndometriumChamber migrationCondition mediumCXCL12
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSCEndometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2015
H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis
Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.Peer-Reviewed Original ResearchConceptsChronic pelvic painReproductive-aged womenEndometrium of womenEndometrial stromal cellsStromal cell growthEndometrial preparationPelvic painEutopic endometriumAged womenEndometriosisNormal controlsStromal cellsH19 expressionImpact fertilityMolecular spongeH19/letNovel therapeuticsReduced proliferationInfertilityWomenEndometriumTurn inhibitsMicroRNA let-7Molecular mechanismsCell growth
2014
Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 2014, 155: 1489-1497. PMID: 24484171, PMCID: PMC3959601, DOI: 10.1210/en.2013-1977.Peer-Reviewed Original ResearchConceptsBZA/CEConjugated estrogensEndometriosis lesionsStem cell recruitmentCell engraftmentStem cell engraftmentCell recruitmentExperimental endometriosisEutopic endometriumUterine endometriumBone marrowSelective estrogen receptor modulator bazedoxifeneStem cellsMesenchymal stem cell engraftmentLesions of endometriosisMale bone marrowUteri of animalsBazedoxifene treatmentCell nuclear antigenEndometriosis interferesOvarian stimulationVehicle treatmentEndometrial functionNormal endometriumOvarian weight
2013
Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Obstetrics And Gynecology 2013, 65: 199-213. PMID: 23598784, PMCID: PMC3718308.Peer-Reviewed Original ResearchConceptsPeritoneal microenvironmentMedical managementDisease pathophysiologyEndometrial progesterone resistanceAppropriate medical managementPathogenesis of endometriosisProgesterone-responsive genesNew therapeutic targetsDisease developmentFemale reproductive tractProgesterone resistanceProinflammatory processesEutopic endometriumRisk factorsProgesterone actionPatients exhibitTherapeutic targetEndometriosisReproductive tractProtein expressionNovel mechanistic frameworkEndometriumInflammationPathophysiologyDisease establishment
2012
Endometriosis and Infertility A Review of the Pathogenesis and Treatment of Endometriosis-associated Infertility
Macer ML, Taylor HS. Endometriosis and Infertility A Review of the Pathogenesis and Treatment of Endometriosis-associated Infertility. Obstetrics And Gynecology Clinics Of North America 2012, 39: 535-549. PMID: 23182559, PMCID: PMC3538128, DOI: 10.1016/j.ogc.2012.10.002.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityEndometriosis-related infertilityTreatment of endometriosisCurrent treatment optionsPotential future treatmentsCoelomic metaplasiaRetrograde menstruationTreatment optionsIntrauterine inseminationEutopic endometriumFallopian tubeEndometriosis pathogenesisFuture treatmentInfertilityEmbryo transportEndometriosisImpact fertilityPathogenesisTreatmentStem cellsA ReviewMetaplasiaEndometriumSurgeryMenstruationMigration of Cells from Experimental Endometriosis to the Uterine Endometrium
Santamaria X, Massasa EE, Taylor HS. Migration of Cells from Experimental Endometriosis to the Uterine Endometrium. Endocrinology 2012, 153: 5566-5574. PMID: 22968642, PMCID: PMC3473215, DOI: 10.1210/en.2012-1202.Peer-Reviewed Original ResearchConceptsEutopic endometriumEctopic lesionsEndometrial tissueExperimental endometriosisGreen fluorescent protein miceEstrogen-dependent growthEutopic endometrial cellsAbsence of leukocytesEndometriotic lesionsEndometrial cellsCell sortingPeritoneal cavityEmbryo implantationUterine endometriumEndometriosisEndometriumMesenchymal transitionLesionsGlobal gene expression profilingGene expression profilingUterusMigration of cellsMiceImmunofluorescenceQuantitative PCRFKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012, 143: 531-538. PMID: 22279148, DOI: 10.1530/rep-11-0438.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsFKBP4 expressionFKBP5 expressionTreatment of hESCCultured human endometrial stromal cellsIGFBP1 expressionEndometrium of womenProtein levelsEndometrial stromal cellsLate proliferative phaseHOXA10 knockdownHOXA10 regulationImpaired decidualizationFertile womenEutopic endometriumMenstrual cycleSecretory phaseEndometriosisDecidualizationHOXA10 expressionProliferative phaseStromal cellsMRNA expressionFKBP5FKBP4
2011
HOX Genes and Endometriosis
Kulp J, Cakmak H, Taylor H. HOX Genes and Endometriosis. 2011, 184-189. DOI: 10.1002/9781444398519.ch18.Peer-Reviewed Original Research
2010
Molecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions
Cakmak H, Taylor H. Molecular Mechanisms of Treatment Resistance in Endometriosis: The Role of Progesterone–Hox Gene Interactions. Seminars In Reproductive Medicine 2010, 28: 069-074. PMID: 20104430, PMCID: PMC3107856, DOI: 10.1055/s-0029-1242996.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionEndometriosis-related infertilityEndometrium of womenExpression of HOXA10Progesterone-responsive genesTime of implantationProgesterone target genesHOXA10 gene expressionEndometrial growthIGFBP-1Progesterone resistanceEndometrial receptivityProgesterone responseEutopic endometriumHuman endometriumProgesterone levelsReceptor expressionTreatment resistanceSex steroidsEndometriosisEndometriumDiminished activityAlphavbeta3 integrinHOXA10Women
2008
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
Lee B, Du H, Taylor HS. Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1. Biology Of Reproduction 2008, 80: 79-85. PMID: 18799756, PMCID: PMC2804809, DOI: 10.1095/biolreprod.108.070391.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEndometriosisEndometriumFemaleGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsImmunohistochemistryInsulin-Like Growth Factor Binding Protein 1Integrin beta ChainsKruppel-Like Transcription FactorsMiceReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsEndometriosis groupEndometrial receptivityEutopic endometriumExperimental endometriosisAltered gene expressionInsulin-like growth factorInduction of endometriosisKruppel-like factor 9Expression of HOXA10Total progesterone receptorEndometrial gene expressionBeta3 mRNA expressionProtein-1 mRNAReal-time RT-PCRQuantitative real-time RT-PCRGene expressionMurine endometriosisNormal endometriumProgesterone receptorMethylation-specific PCREndometriosisEndometriumMRNA expressionEctopic locationsGrowth factor
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