2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2019
CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMice
2018
Uterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceBone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
Yi KW, Mamillapalli R, Sahin C, Song J, Tal R, Taylor HS. Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model. Biology Of Reproduction 2018, 100: 61-70. PMID: 30084961, PMCID: PMC6335209, DOI: 10.1093/biolre/ioy175.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsThin endometriumEndometrial regenerationComparable efficacyTherapeutic effectC motif chemokine 12Potential therapeutic effectsMatrix metalloproteinase-2MRNA expression levelsLeukemia inhibitory factorIntegrin beta 3Endometrial growthEndometrial receptivityCD31 immunoreactivityInterleukin-1βPregnancy rateKi-67Mouse modelEpithelial areaSuccessful implantationMetalloproteinase-2EndometriumCXCL12Inhibitory factorInsulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role
2017
Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X. Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis. Fertility And Sterility 2017, 108: 858-867.e2. PMID: 28923287, DOI: 10.1016/j.fertnstert.2017.08.018.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsProtein-coupled receptorsEutopic endometriumEpithelial markersHealthy egg donorsHuman eutopic endometriumType of endometriosisEndometrium of womenMenstrual cycle phaseProspective experimental studyParaffin-embedded tissuesEndometriotic patientsInflammatory markersEndometrial samplesUterine aspiratesHuman endometriumLeucine-rich repeatsFluorescence-activated cell sortingPathologic endometriumMAIN OUTCOMEEndometriosisReproductive outcomesEndometriumFertility clinicsStromal compartmentStem cell therapies for atrophic endometrium and Asherman's syndrome
Seifer B, Naqvi H, Samani E, Krikun G, Taylor H. Stem cell therapies for atrophic endometrium and Asherman's syndrome. 2017, 217-227. DOI: 10.1201/9781315151472-16.Peer-Reviewed Original ResearchAsherman's syndromeAtrophic endometriumBone marrow stem cell transplantationMarrow stem cell transplantationCell therapyCommon clinical featuresStem cell transplantationNovel therapeutic approachesAvailability of providersStem cell therapyCommon pathologicIntrauterine synechiaeMenstrual irregularitiesClinical featuresCell transplantationNormal endometriumCase reportMurine modelTherapeutic approachesHuman studiesEndometriumSignificant injurySyndromeFibrous tissueNew stem cellsHormonal regulation of the endometrium and the effects of hormonal therapies
Ersoy G, Modi M, Alderman M, Taylor H. Hormonal regulation of the endometrium and the effects of hormonal therapies. 2017, 161-176. DOI: 10.1201/9781315151472-11.ChaptersSelective progesterone receptor modulatorsSelective estrogen receptor modulatorsMenopausal hormone therapyIntrauterine deviceOral contraceptivesMedroxyprogesterone acetateMenstrual cycleReceptor modulatorsGonadotropin-releasing hormone agonistProgesterone receptor modulatorsEstrogen receptor modulatorsHuman menstrual cycleHormonal regulationPractice of obstetricsHormonal therapyHormone therapyMenstrual bleedingEndometrial receptivityHormone agonistTestosterone signalingHormonal treatmentSecretory phaseEmbryo implantationEndometriumProliferative phaseBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS. Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reproductive Sciences 2017, 24: 526-533. PMID: 27729562, PMCID: PMC5933203, DOI: 10.1177/1933719116672587.Peer-Reviewed Original ResearchConceptsEutopic endometriumEndometriotic lesionsChemotactic activityCXCR4 messenger RNAProtein expressionTreatment of endometriosisCXCR4 protein expressionStem cellsExpression of CXCL12CXCL12/CXCR4Transwell chamber migrationCXCL12 protein expressionEnzyme-linked immunosorbentBone marrow stem cellsBone marrow cellsMouse bone marrow stem cellsMarrow stem cellsEndometrial tissueControl endometriumGynecological disordersEndometriosisEndometriumChamber migrationCondition mediumCXCL12
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSCThe effect of elagolix on the endometrium: safety results from two randomized, placebo-controlled studies in women with endometriosis-associated pain
Diamond M, Simon J, Lessey B, Taylor H, Rowan J, Chwalisz K, Schwefel B, Thomas J, Jain R, Williams L. The effect of elagolix on the endometrium: safety results from two randomized, placebo-controlled studies in women with endometriosis-associated pain. Fertility And Sterility 2016, 106: e94-e95. DOI: 10.1016/j.fertnstert.2016.07.274.Peer-Reviewed Original ResearchEndometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2015
H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis
Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.Peer-Reviewed Original ResearchConceptsChronic pelvic painReproductive-aged womenEndometrium of womenEndometrial stromal cellsStromal cell growthEndometrial preparationPelvic painEutopic endometriumAged womenEndometriosisNormal controlsStromal cellsH19 expressionImpact fertilityMolecular spongeH19/letNovel therapeuticsReduced proliferationInfertilityWomenEndometriumTurn inhibitsMicroRNA let-7Molecular mechanismsCell growthChemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Research 2015, 15: 14-22. PMID: 25957946, PMCID: PMC5001152, DOI: 10.1016/j.scr.2015.04.004.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsBone marrow cellsEndometrial stromal cellsCXCR4 expressionEndometrial cellsBM cellsCXCL12/CXCR4 expressionStromal cellsBone marrow-derived stem cellsMarrow-derived stem cellsHuman endometrial cellsStem cellsEndometrial disordersCXCL12 receptorCXCR4 antagonistCXCL12 expressionChemokine CXCL12Uterine endometriumCells engraftBone marrowEndometriumMarrow cellsStem cell migrationCXCR4CXCL12
2014
The noncoding RNAs H19 and let-7 alter IGF signaling and stromal cell growth in the endometrium of women with endometriosis
Ghazal S, McKinnon B, Zhou J, Mueller M, Flannery C, Huang Y, Taylor H. The noncoding RNAs H19 and let-7 alter IGF signaling and stromal cell growth in the endometrium of women with endometriosis. Fertility And Sterility 2014, 102: e5-e6. DOI: 10.1016/j.fertnstert.2014.07.025.Peer-Reviewed Original ResearchBone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
Alawadhi F, Du H, Cakmak H, Taylor HS. Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome. PLOS ONE 2014, 9: e96662. PMID: 24819371, PMCID: PMC4018329, DOI: 10.1371/journal.pone.0096662.Peer-Reviewed Original ResearchConceptsAsherman's syndromeMurine modelBone marrowIschemia/reperfusion injurySyndrome modelNon-transplanted groupStem cell transplantationUninjured control groupPotential novel treatmentTransplant groupUterine repairIntrauterine adhesionsReperfusion injuryCell transplantationNormal endometriumUterine injuryStem cell recruitmentEndometrial cellsUninjured controlsCell recruitmentNovel treatmentsUterine hornControl groupEndometriumSyndrome
2013
Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Obstetrics And Gynecology 2013, 65: 199-213. PMID: 23598784, PMCID: PMC3718308.Peer-Reviewed Original ResearchConceptsPeritoneal microenvironmentMedical managementDisease pathophysiologyEndometrial progesterone resistanceAppropriate medical managementPathogenesis of endometriosisProgesterone-responsive genesNew therapeutic targetsDisease developmentFemale reproductive tractProgesterone resistanceProinflammatory processesEutopic endometriumRisk factorsProgesterone actionPatients exhibitTherapeutic targetEndometriosisReproductive tractProtein expressionNovel mechanistic frameworkEndometriumInflammationPathophysiologyDisease establishment
2012
Endometriosis and Infertility A Review of the Pathogenesis and Treatment of Endometriosis-associated Infertility
Macer ML, Taylor HS. Endometriosis and Infertility A Review of the Pathogenesis and Treatment of Endometriosis-associated Infertility. Obstetrics And Gynecology Clinics Of North America 2012, 39: 535-549. PMID: 23182559, PMCID: PMC3538128, DOI: 10.1016/j.ogc.2012.10.002.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityEndometriosis-related infertilityTreatment of endometriosisCurrent treatment optionsPotential future treatmentsCoelomic metaplasiaRetrograde menstruationTreatment optionsIntrauterine inseminationEutopic endometriumFallopian tubeEndometriosis pathogenesisFuture treatmentInfertilityEmbryo transportEndometriosisImpact fertilityPathogenesisTreatmentStem cellsA ReviewMetaplasiaEndometriumSurgeryMenstruationMigration of Cells from Experimental Endometriosis to the Uterine Endometrium
Santamaria X, Massasa EE, Taylor HS. Migration of Cells from Experimental Endometriosis to the Uterine Endometrium. Endocrinology 2012, 153: 5566-5574. PMID: 22968642, PMCID: PMC3473215, DOI: 10.1210/en.2012-1202.Peer-Reviewed Original ResearchConceptsEutopic endometriumEctopic lesionsEndometrial tissueExperimental endometriosisGreen fluorescent protein miceEstrogen-dependent growthEutopic endometrial cellsAbsence of leukocytesEndometriotic lesionsEndometrial cellsCell sortingPeritoneal cavityEmbryo implantationUterine endometriumEndometriosisEndometriumMesenchymal transitionLesionsGlobal gene expression profilingGene expression profilingUterusMigration of cellsMiceImmunofluorescenceQuantitative PCRIschemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium
Du H, Naqvi H, Taylor HS. Ischemia/Reperfusion Injury Promotes and Granulocyte-Colony Stimulating Factor Inhibits Migration of Bone Marrow-Derived Stem Cells to Endometrium. Stem Cells And Development 2012, 21: 3324-3331. PMID: 22897736, PMCID: PMC3516416, DOI: 10.1089/scd.2011.0193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationCell DifferentiationCell MovementCell ProliferationEndometriumEstrous CycleFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLRegenerationReperfusion InjuryStem CellsUterusConceptsGranulocyte-colony stimulating factorSex steroidsMesenchymal stem cellsUterine repairUterine injuryBone marrowEstrous cycleIschemia/reperfusion injuryStem cellsBM-derived cellsG-CSF treatmentBM transplantsReperfusion injuryBM engraftmentIschemic injuryStem cell recruitmentMenstrual cycleMSC engraftmentCell recruitmentEndometriumInhibits migrationInjuryHematopoietic stem cellsStimulating factorUterus
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply