2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDisease
2021
Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration
Tal A, Tal R, Kliman HJ, Taylor HS. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. American Journal Of Pathology 2021, 191: 1292-1302. PMID: 33964217, PMCID: PMC8261475, DOI: 10.1016/j.ajpath.2021.04.011.Peer-Reviewed Original ResearchConceptsEndometriosis lesionsEpithelial compartmentLesion numberDisruption of CXCR4Intraepithelial lymphocyte infiltrationAdult female miceLoss of CXCR4CXCL12-CXCR4 axisTotal lesion areaProgesterone receptor promoterEndometriosis inductionLymphocyte infiltrationCXCR4 expressionFemale miceHost miceControl lesionsProestrus stageEpithelial proliferationImmune evasionCXCR4LesionsTherapeutic potentialLesion areaReduces ProliferationEpithelial cells
2019
miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice
Li M, Zhou Y, Taylor HS. miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice. Reproductive Sciences 2019, 26: 1506-1511. PMID: 31354069, DOI: 10.1177/1933719119862050.Peer-Reviewed Original ResearchConceptsMiR-451a inhibitorReproductive-age womenTreatment of endometriosisPro-inflammatory diseasesSystemic treatmentEndometriosis lesionsIL-6Chronic diseasesPromising therapyCurrent treatmentMicroRNA-451aMurine modelSex steroidsEndometriosisLesion sizeVisible lesionsMiR-451aMicroRNAs treatmentsDiseaseAltered expressionΒ-cateninTreatmentLesionsInhibitorsMultiple pathwaysEvaluation of miR-135a/b expression in endometriosis lesions
Petracco R, De Oliveira Dias A, Taylor H, Petracco Á, Badalotti M, Da Rosa Michelon J, Marinowic DR, Hentschke M, De Azevedo P, Zanirati G, Machado DC. Evaluation of miR-135a/b expression in endometriosis lesions. Biomedical Reports 2019, 11: 181-187. PMID: 31565224, PMCID: PMC6759580, DOI: 10.3892/br.2019.1237.Peer-Reviewed Original ResearchEndometriosis lesionsEndometrium tissuesSecretory phaseProliferative phaseExpression levelsReverse transcription‑quantitative polymerase chain reaction assaysEctopic endometriosis lesionsTranscription-quantitative polymerase chain reaction assaysPathogenesis of endometriosisEctopic endometrium tissuesEutopic endometrium tissuesPolymerase chain reaction assaysEndometrial functioningEndometrial receptivityMenstrual cycleChain reaction assaysLaparoscopic surgeryPost-transcriptional regulationEmbryo implantationQuantitative polymerase chain reaction assaysShort noncoding RNAsB expressionIncreased expressionExpression of genesLesionsEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Characterization of cell fusion in an experimental mouse model of endometriosis†
Tal A, Tal R, Shaikh S, Gidicsin S, Mamillapalli R, Taylor H. Characterization of cell fusion in an experimental mouse model of endometriosis†. Biology Of Reproduction 2018, 100: 390-397. PMID: 30304517, PMCID: PMC7302516, DOI: 10.1093/biolre/ioy221.Peer-Reviewed Original ResearchConceptsMouse modelLimited proliferative activityFunctional endometrial tissueBone marrow transplantation modelExperimental mouse modelEndometrial stem cellsPrincipal cell sourceRepair/regeneration processBone marrow cellsEndometriosis shareCell fusionEndometrial tissueEndometriosis lesionsEndometriotic lesionsUterine cavityTransplantation modelCell fusion eventsCre-lox systemEndometriosisEpithelial markersStromal compartmentLesionsMarrow cellsProliferative activitySca-1Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
Li F, Alderman MH, Tal A, Mamillapalli R, Coolidge A, Hufnagel D, Wang Z, Neisani E, Gidicsin S, Krikun G, Taylor HS. Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 2018, 36: 881-890. PMID: 29450941, PMCID: PMC5992028, DOI: 10.1002/stem.2804.Peer-Reviewed Original ResearchConceptsSerum CXCL12 levelsCXCL12 levelsEndometrial tissueEndometriosis lesionsHematogenous disseminationMesenchymal stem cell biomarkersCXCL12/CXCR4 axisStem cellsTreatment of endometriosisSham control miceEndometrial stem cellsHematopoietic stem cell markersStem cell biomarkersStem cell markersSpontaneous endometriosisRetrograde menstruationControl miceExperimental endometriosisRecipient miceCXCR4 axisLung tissueEndometriosisPeritoneal cavityDsRed miceBlood of animalsIcon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis
Hufnagel D, Goetz L, Hu Z, Nyachieo A, D’Hooghe T, Fazleabas A, Duleba A, Krikun G, Taylor HS, Lockwood CJ. Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis. Reproductive Biology 2018, 18: 109-114. PMID: 29422377, DOI: 10.1016/j.repbio.2018.01.009.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAdnexal DiseasesAmino Acid SubstitutionAnimalsEndometriosisFactor VIIFemaleGenetic TherapyGenetic VectorsHumansImmunoconjugatesImmunoglobulin Fc FragmentsImmunoglobulin GMolecular Targeted TherapyMutationNeovascularization, PathologicPapio anubisPelvisPeptide FragmentsRandom AllocationRecombinant Fusion ProteinsThromboplastinConceptsNon-human primatesNovel treatmentsTissue factorNon-human primate modelRegression of endometriosisEctopic endometrial tissueReproductive-aged womenEctopic endometrial lesionsWeekly intraperitoneal injectionsFactor VII/VIIaLesion vasculatureChronic painEndometrial lesionsEndometrial tissueEndometriosis lesionsLaparoscopic confirmationSurgical inductionIntraperitoneal injectionPrimate modelCommon conditionMurine modelEndometriosisTreatment groupsControl groupTreatment results
2017
Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Sahin Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS. Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reproductive Sciences 2017, 24: 818-823. PMID: 28256937, DOI: 10.1177/1933719116682879.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMedroxyprogesterone acetateEstrogen deprivationEndometriosis lesionsStem cell recruitmentCell recruitmentLesions of endometriosisGreen fluorescent protein miceWeeks of treatmentBone marrow transplantLong-term treatmentMarrow-derived stem cellsStem cellsProgestin medroxyprogesterone acetateLong-term regressionBone marrow stem cellsStem cell engraftmentMarrow stem cellsProgestin therapyEndometriosis treatmentLesion regressionMedical therapyEndometriotic lesionsMarrow transplantC57BL/6 mice
2016
Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2014
Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 2014, 155: 1489-1497. PMID: 24484171, PMCID: PMC3959601, DOI: 10.1210/en.2013-1977.Peer-Reviewed Original ResearchConceptsBZA/CEConjugated estrogensEndometriosis lesionsStem cell recruitmentCell engraftmentStem cell engraftmentCell recruitmentExperimental endometriosisEutopic endometriumUterine endometriumBone marrowSelective estrogen receptor modulator bazedoxifeneStem cellsMesenchymal stem cell engraftmentLesions of endometriosisMale bone marrowUteri of animalsBazedoxifene treatmentCell nuclear antigenEndometriosis interferesOvarian stimulationVehicle treatmentEndometrial functionNormal endometriumOvarian weight
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