2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2021
Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus
Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.Peer-Reviewed Original ResearchConceptsPostpartum uterusEndometrial stem/progenitor cellsBone marrow-derived progenitor cellsMarrow-derived progenitor cellsF4/80 macrophage markerUterine tissue regenerationProgenitor cellsC57BL/6J female micePostpartum day 1Cytokeratin-positive epithelial cellsBlood vessel endotheliumStem/progenitor cellsPrepregnancy levelsBM transplantsEndometrial regenerationEndometrial cellsFemale miceMacrophage markersPan-leukocytesLuminal epitheliumBone marrowDay 1BMDCsUterine cellsVessel endothelium
2019
CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMice
2018
Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
Yi KW, Mamillapalli R, Sahin C, Song J, Tal R, Taylor HS. Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model. Biology Of Reproduction 2018, 100: 61-70. PMID: 30084961, PMCID: PMC6335209, DOI: 10.1093/biolre/ioy175.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsThin endometriumEndometrial regenerationComparable efficacyTherapeutic effectC motif chemokine 12Potential therapeutic effectsMatrix metalloproteinase-2MRNA expression levelsLeukemia inhibitory factorIntegrin beta 3Endometrial growthEndometrial receptivityCD31 immunoreactivityInterleukin-1βPregnancy rateKi-67Mouse modelEpithelial areaSuccessful implantationMetalloproteinase-2EndometriumCXCL12Inhibitory factor
2016
A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction
Tal R, Liu Y, Pluchino N, Shaikh S, Mamillapalli R, Taylor H. A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction. Endocrinology 2016, 157: 3749-3759. PMID: 27427897, PMCID: PMC6285241, DOI: 10.1210/en.2016-1418.Peer-Reviewed Original ResearchConceptsStem cell factorDonor chimerismOvarian functionBone marrowIntact ovarian functionGreen fluorescent protein miceTransgenic green fluorescent protein (GFP) miceEndometrial regenerationRegimen resultsEndometrial stromaControl miceTransplant modelBM cellsBMDCsCTX-1CD31 stainingImmunohistochemical analysisDay 28Cell traffickingUterine cellsUterusBMTCD45 markersMiceCytometry analysis
2013
Stem cells and the reproductive system: Historical perspective and future directions
Duke CM, Taylor HS. Stem cells and the reproductive system: Historical perspective and future directions. Maturitas 2013, 76: 284-289. PMID: 24144960, DOI: 10.1016/j.maturitas.2013.08.012.Peer-Reviewed Original ResearchConceptsEndometrial-derived stem cellsStem cellsNumber of oocytesBone marrow stem cellsFuture therapeutic benefitMarrow stem cellsEndometrial regenerationParenchymal regenerationEndometrial tissueFertility preservationUterine disordersDerived stem cellsFetal stem cellsHuman ovaryMaternal circulationParkinson's diseaseTherapeutic benefitNovel treatmentsMultipotent stem cellsFetal cellsReproductive diseasesDiseaseDisease statesMature oocytesReproductive system
2012
Endometrial Stem Cells.
Taylor H. Endometrial Stem Cells. Biology Of Reproduction 2012, 87: 32-32. DOI: 10.1093/biolreprod/87.s1.32.Peer-Reviewed Original ResearchProgenitor stem cellsMesenchymal stem cellsUterine injuryMenstrual cycleMultipotent stem cellsStem cellsAdult progenitor stem cellsPathogenesis of endometriosisEndometrial stem cellsMurine diabetes modelPancreatic beta cellsAsherman's syndromeEndometrial regenerationDopaminergic neuronsDiabetes modelRetrograde fashionMurine modelPeritoneal cavitySex steroidsParkinson's diseaseBeta cellsBone marrowEndometriosisRemarkable regenerative capacityEctopic locations
2010
Stem cells and reproduction
Du H, Taylor HS. Stem cells and reproduction. Current Opinion In Obstetrics & Gynecology 2010, 22: 235-241. PMID: 20305558, PMCID: PMC3107846, DOI: 10.1097/gco.0b013e328338c152.Peer-Reviewed Original ResearchConceptsStem cellsCause of endometriosisBone marrow transplantBone marrow stem cellsMarrow stem cellsStem cell biologyEndometrial regenerationMarrow transplantUterine disordersFetal stem cellsOrthotopic transplantationOvarian cancerMaternal circulationLive birthsEnd organsOvarian tissueFetal cellsUnderlying causeClinical potentialCell biologyMature oocytesDynamic organCell transformationNovel evidenceWomen
2009
Stem Cells and Female Reproduction
Du H, Taylor HS. Stem Cells and Female Reproduction. Reproductive Sciences 2009, 16: 126-139. PMID: 19208782, PMCID: PMC3129037, DOI: 10.1177/1933719108329956.Peer-Reviewed Original ResearchConceptsStem cellsStem cell biologyEndometrial-derived stem cellsNon-reproductive tissuesDerived stem cellsReproductive biologyHematopoietic stem cellsCell biologyEtiology of endometriosisFemale reproductionMaternal diseaseEndometrial regenerationUterine disordersBone marrowRecent findingsBiologyMature oocytesReproductive diseasesCellsOocytesDiseaseTreatmentPotential implicationsReproductionEndometriosis
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