2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometriumImpact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cellsQuinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial
Pellicer A, Taylor H, Alberich-Bayarri A, Liu Y, Gamborg M, Barletta K, Pinton P, Heiser P, Bagger Y. Quinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2025, 310: 113946. PMID: 40188683, DOI: 10.1016/j.ejogrb.2025.113946.Peer-Reviewed Original ResearchConceptsDeep infiltrating endometriosisVaginal ringNo significant differenceLesion sizeBleeding patternsMenstrual cycleSignificant differenceImaging biomarkersSerum prolactin levelsPhase 2 trialMenstrual bleeding patternsEndpoint of reductionPatient-reported outcomesHigh-resolution MRIInfiltrating endometriosisPlacebo groupDouble-blindPlacebo-ControlledAdvanced diseaseEndometriotic lesionsPrimary endpointPain reductionSecondary endpointsProlactin levelsAdverse events
2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical response
2023
Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice
Habata S, Mamillapalli R, Ucar A, Taylor H. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem Cells International 2023, 2023: 1598127. PMID: 37545483, PMCID: PMC10403325, DOI: 10.1155/2023/1598127.Peer-Reviewed Original ResearchBone marrowMesenchymal stem cellsBM transplantsEndometriotic lesionsM2 macrophagesBone marrow-derived inflammatory cellsTumor necrosis factor alphaImmune system contributionsDonor mesenchymal stem cellsProportion of M1Infiltration of macrophagesDevelopment of endometriosisNecrosis factor alphaNew therapeutic targetsRecipient bone marrowReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEndometriotic lesion developmentInflammatory markersEndometrial tissueInflammatory cellsRecipient micePolymerase chain reactionInflammatory responseFluorescence-activated cell sorting
2022
Endometriosis promotes atherosclerosis in a murine model
Mamillapalli R, Toffoloni N, Habata S, Qunhua H, Atwani R, Stachenfeld N, Taylor HS. Endometriosis promotes atherosclerosis in a murine model. American Journal Of Obstetrics And Gynecology 2022, 227: 248.e1-248.e8. PMID: 35351413, PMCID: PMC9308711, DOI: 10.1016/j.ajog.2022.03.040.Peer-Reviewed Original ResearchConceptsEffect of endometriosisOil Red O stainingVascular endothelial growth factorMurine modelCardiovascular diseaseRed O stainingEndothelial growth factorSham miceEndometriotic lesionsInflammatory cytokinesInterleukin-6Luminal areaInterferon gammaO stainingGrowth factorAortic luminal areasInflammatory-related cytokinesRoot wall thicknessUnderwent sham surgeryTreatment of endometriosisInflammation-related cytokinesDevelopment of atherosclerosisApolipoprotein E (ApoE-/- ) miceLong-term riskWeeks of induction
2021
Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2020
Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells. Reproductive Sciences 2020, 28: 426-434. PMID: 32812213, DOI: 10.1007/s43032-020-00294-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCDC2 Protein KinaseCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLParacrine CommunicationSignal TransductionStromal CellsConceptsBone marrow-derived stem cellsCell proliferationEndometrial cellsEstrogen-dependent gynecological disorderPrimary endometrial stromal cellsEndometrial stromal cell proliferationEndometriosis cell proliferationReproductive-aged womenEndometrial stromal cellsNormal endometrial cellsEndometrial cell proliferationMarrow-derived stem cellsNovel therapeutic strategiesStromal cell proliferationBone marrow mesenchymal stem cellsStem cellsSignificant clonal expansionMarrow mesenchymal stem cellsPelvic painEndometriotic lesionsEndometriosis growthGynecological disordersEndometriosis cell linesMouse modelEndometriosisEndometriosis: The Role of Iron Overload and Ferroptosis
Ng SW, Norwitz SG, Taylor HS, Norwitz ER. Endometriosis: The Role of Iron Overload and Ferroptosis. Reproductive Sciences 2020, 27: 1383-1390. PMID: 32077077, DOI: 10.1007/s43032-020-00164-z.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsIron overloadRetrograde menstruationEndometrial tissueSubsequent pathophysiologyEutopic endometriumRisk factorsAbdominal cavityWomen's healthReproductive disordersIron deficiencyEndometriosisSuch disordersLesionsIron excessPrimary defectEctopic sitesCholesterol biosynthetic pathwayNon-apoptotic programmed cell deathCell survivalCell deathIron homeostasisDisordersFerroptosisOverloadCXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, Taylor HS. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. Journal Of Cellular And Molecular Medicine 2020, 24: 2464-2474. PMID: 31904910, PMCID: PMC7028867, DOI: 10.1111/jcmm.14933.Peer-Reviewed Original ResearchConceptsCXCR7 antagonistLesion sizePro-inflammatory cytokine productionBone marrow-derived cellsNon-hormonal therapiesMouse bone marrow transplantation modelBone marrow transplantation modelBone marrow cell migrationMarrow-derived cellsProgression of endometriosisEndometriosis implantsEndometrial effectsAntagonist treatmentEndometriotic lesionsCytokine productionEndometrial physiologyStem cell recruitmentEutopic endometriumTransplantation modelCell recruitmentNull miceCell traffickingEndometriosisEpithelial cell fateCXCR4
2019
Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis
Hu Z, Mamillapalli R, Taylor HS. Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis. AJP Endocrinology And Metabolism 2018, 316: e373-e382. PMID: 30576245, PMCID: PMC6459299, DOI: 10.1152/ajpendo.00244.2018.Peer-Reviewed Original ResearchConceptsEndometriotic cellsSteroidogenic factor 1Primary endometriotic cellsReproductive-aged womenAltered expressionSera of patientsPathogenesis of endometriosisCell proliferationFactor 1SF-1Novel therapeutic strategiesSteroidogenic acute regulatory proteinGynecologic diseaseEndometrial tissueEndometriotic lesionsAcute regulatory proteinSF-1 mRNA levelsEndometriosisTherapeutic strategiesEstrogen biosynthesisMRNA levelsRespective controlsWomenEssential transcriptional regulatorSerumProgesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis
Flores VA, Vanhie A, Dang T, Taylor HS. Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4561-4568. PMID: 30357380, PMCID: PMC6226602, DOI: 10.1210/jc.2018-01227.Peer-Reviewed Original ResearchConceptsProgestin-based therapyPR statusReceptor statusEndometriotic lesionsPredictive valueEndometriosis-associated painProgesterone receptor levelsRetrospective cohort studyFirst-line treatmentProgesterone receptor statusNegative predictive valuePositive predictive valueElectronic medical recordsRabbit polyclonal IgGPrecision-based approachesProgestin therapyHormonal therapyEndometriosis treatmentCohort studyPredictive markerMedical recordsReceptor levelsH-scoreAcademic centersEndometriosisCharacterization of cell fusion in an experimental mouse model of endometriosis†
Tal A, Tal R, Shaikh S, Gidicsin S, Mamillapalli R, Taylor H. Characterization of cell fusion in an experimental mouse model of endometriosis†. Biology Of Reproduction 2018, 100: 390-397. PMID: 30304517, PMCID: PMC7302516, DOI: 10.1093/biolre/ioy221.Peer-Reviewed Original ResearchConceptsMouse modelLimited proliferative activityFunctional endometrial tissueBone marrow transplantation modelExperimental mouse modelEndometrial stem cellsPrincipal cell sourceRepair/regeneration processBone marrow cellsEndometriosis shareCell fusionEndometrial tissueEndometriosis lesionsEndometriotic lesionsUterine cavityTransplantation modelCell fusion eventsCre-lox systemEndometriosisEpithelial markersStromal compartmentLesionsMarrow cellsProliferative activitySca-1Bazedoxifene–Conjugated Estrogens for Treating Endometriosis
Flores VA, Stachenfeld NS, Taylor HS. Bazedoxifene–Conjugated Estrogens for Treating Endometriosis. Obstetrics And Gynecology 2018, 132: 475-477. PMID: 29995747, DOI: 10.1097/aog.0000000000002739.Peer-Reviewed Original ResearchConceptsConjugated estrogensPelvic painTreatment optionsStage III endometriosisCyclic pelvic painFirst-line therapyReproductive-aged womenPotential treatment optionManagement of dysmenorrheaUnfavorable side effectsEndometriotic lesionsGynecologic disordersHormonal agentsMenopausal symptomsOvarian parametersSide effectsAnimal studiesEndometriosisEstrogenBazedoxifenePainEffective alternativeFailure rateAbnormal effectsDysmenorrhea
2017
Effect of simvastatin on baboon endometriosis†
Taylor HS, Alderman M, D'Hooghe TM, Fazleabas AT, Duleba AJ. Effect of simvastatin on baboon endometriosis†. Biology Of Reproduction 2017, 97: 32-38. PMID: 28637327, PMCID: PMC6248548, DOI: 10.1093/biolre/iox058.Peer-Reviewed Original ResearchConceptsEffect of simvastatinEndometriotic lesionsRed lesionsMarkers of inflammationEndometrial stromal cellsDevelopment of endometriosisEstrogen receptor betaImmune system activationEstrogen receptor alphaMarkers of proliferationSteroid hormone responsesCell nuclear antigenEndometrial lesionsEndometrial tissueEutopic endometriumReproductive agePrimate modelWhite lesionsCommon disorderEstrogen receptorBaboon modelMurine modelTreatment groupsSystem activationReceptor alphaMedical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Sahin Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS. Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reproductive Sciences 2017, 24: 818-823. PMID: 28256937, DOI: 10.1177/1933719116682879.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMedroxyprogesterone acetateEstrogen deprivationEndometriosis lesionsStem cell recruitmentCell recruitmentLesions of endometriosisGreen fluorescent protein miceWeeks of treatmentBone marrow transplantLong-term treatmentMarrow-derived stem cellsStem cellsProgestin medroxyprogesterone acetateLong-term regressionBone marrow stem cellsStem cell engraftmentMarrow stem cellsProgestin therapyEndometriosis treatmentLesion regressionMedical therapyEndometriotic lesionsMarrow transplantC57BL/6 miceMicrometastasis of endometriosis to distant organs in a murine model
Samani EN, Mamillapalli R, Li F, Mutlu L, Hufnagel D, Krikun G, Taylor HS. Micrometastasis of endometriosis to distant organs in a murine model. Oncotarget 2017, 10: 2282-2291. PMID: 31040919, PMCID: PMC6481344, DOI: 10.18632/oncotarget.16889.Peer-Reviewed Original ResearchPeritoneal cavityMultiple organsDistant organsDiffuse clinical manifestationsMurine endometriosis modelReproductive-aged womenDisseminated endometriosisEndometriosis modelRetrograde menstruationClinical manifestationsEndometrial tissueEndometriotic lesionsImmunocompetent miceFallopian tubeEndometrial cellsGynecological disordersMurine modelMouse modelEndometriosisExperimental animalsEngraftmentMicrometastasisImmunofluorescence analysisOrgansDiseaseBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS. Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reproductive Sciences 2017, 24: 526-533. PMID: 27729562, PMCID: PMC5933203, DOI: 10.1177/1933719116672587.Peer-Reviewed Original ResearchConceptsEutopic endometriumEndometriotic lesionsChemotactic activityCXCR4 messenger RNAProtein expressionTreatment of endometriosisCXCR4 protein expressionStem cellsExpression of CXCL12CXCL12/CXCR4Transwell chamber migrationCXCL12 protein expressionEnzyme-linked immunosorbentBone marrow stem cellsBone marrow cellsMouse bone marrow stem cellsMarrow stem cellsEndometrial tissueControl endometriumGynecological disordersEndometriosisEndometriumChamber migrationCondition mediumCXCL12
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSC
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